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  1. 621
    “…We found that cyclin G2 regulated the expression of renal glomerulosclerosis-related proteins via the canonical Wnt signalling pathway in glomerular mesangial cells. …”
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    Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling
  2. 622
    “…However, there is currently no general algorithm for deciding how to handle the missing data given a specific DAG. Here we construct “canonical” DAGs capturing typical missingness mechanisms in epidemiologic studies with incomplete data on exposure, outcome, and confounding factors. …”
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    Canonical Causal Diagrams to Guide the Treatment of Missing Data in Epidemiologic Studies
  3. 623
    por Yi, Young-Su
    Publicado 2018
    “…Although inflammation protects the host from harmful stimuli, chronic inflammation is a critical risk factor for inflammatory diseases, and several studies have investigated the role of canonical inflammasomes in inflammatory responses and diseases, with emerging studies focusing on the role of non-canonical inflammasomes. …”
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    Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases
  4. 624
    “…There is a canonical life-history trade-off between quantity and quality of offspring, but molecular determinants for this are unknown. …”
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    TNFα is responsible for the canonical offspring number-size trade-off
  5. 625
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    Progression of the canonical reference malaria parasite genome from 2002–2019
  6. 626
    “…Canonical Wnt signaling is emerging as a major regulator of endocytosis. …”
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    Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins
  7. 627
    “…Canonical inflammasome activation is a tightly regulated process that has been implicated in a broad spectrum of inflammatory disorders. …”
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    Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry
  8. 628
    “…This sequence adopted an extensively polymorphic G-quadruplex, including non-canonical bulged G-quadruplex folds that co-existed in solution. …”
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    Bulged and Canonical G-Quadruplex Conformations Determine NDPK Binding Specificity
  9. 629
    “…Background and objectives: Dysregulation of TGF-β signaling plays multiple roles in cancer development and progression. In the canonical TGF-β pathway, TGF-β regulates the expression of hundreds of target genes via interaction with Smads, signal transducers and transcriptional modulators. …”
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    Prognostic Impact of Canonical TGF-β Signaling in Urothelial Bladder Cancer
  10. 630
    “…Furthermore, the predicted cytoskeletal systems, the organization of endomembrane systems, and biosynthetic pathways also display canonical eukaryotic complexity. The only apparent preadaptation that permitted the loss of mitochondria was the acquisition of the SUF system for Fe–S cluster assembly and the loss of glycine cleavage system. …”
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    The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion
  11. 631
    “…Two non-canonical ETEC antigens, the EtpA adhesin, and the EatA mucinase are immunogenic in humans and protective in animal models. …”
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    Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli
  12. 632
    “…In addition, several non-canonical miRNA-containing genes have been recently described and unexpected functions of miRNAs have been identified. …”
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    The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation
  13. 633
    “…This combined approach intertwining NMR spectroscopy with MD simulations makes it possible to describe the conformational space non-canonically Lys11-, and Lys27-linked ubiquitin dimers occupy in a solution averaged ensemble by taking atomically resolved information representing all residues in ubiquitin dimers into account.…”
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    Conformational and functional characterization of artificially conjugated non-canonical ubiquitin dimers
  14. 634
    “…Together this work expands our interpretation of the protein coding genome and demonstrates the critical nature of proteinaceous products generated from non-canonical ORFs to the immune response in vivo. We therefore propose that the misannotation of non-canonical ORF-containing genes as non-coding RNAs may obscure the essential role of a multitude of previously undiscovered protein coding genes in immunity and disease.…”
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    The Translation of Non-Canonical Open Reading Frames Controls Mucosal Immunity
  15. 635
    “…On the other hand, the conserved ftsK appeared to be essential in this bacterium. In conclusion, the canonical bacterial cell division machinery is not essential in P. limnophila and this bacterium divides via budding using an unknown mechanism.…”
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    Non-essentiality of canonical cell division genes in the planctomycete Planctopirus limnophila
  16. 636
    “…Upon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. …”
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    Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA
  17. 637
    “…Transient receptor potential canonical (TRPC) channels are involved in the regulation of cardiac function under (patho)physiological conditions and are closely associated with the pathogenesis of cardiac hypertrophy, arrhythmias, and myocardial infarction. …”
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    Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology
  18. 638
    “…One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. …”
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    Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
  19. 639
    “…Exploring molecular players mediating Ca(2+) entry into cells and molecular mechanisms underlying activity-dependent changes in Ca(2+) signaling in the somatosensory pain pathway is therefore helpful towards understanding the development of chronic, pathological pain. Canonical transient receptor potential (TRPC) channels form a subfamily of nonselective cation channels, which permit the permeability of Ca(2+) and Na+ into the cells. …”
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    Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain
  20. 640
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    Understanding biochemical design principles with ensembles of canonical non-linear models
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