Mostrando 801 - 820 Resultados de 23,561 Para Buscar '"canonization"', tiempo de consulta: 0.28s Limitar resultados
  1. 801
    “…A nucleoside analogue comprising the ligand 1H-imidazo[4,5-f][1,10]phenanthroline (P) was applied to develop a molecular beacon capable of discriminating the canonical nucleobases cytosine and thymine. The beacon is based on the formation of a stable Ag(+)-mediated base pair between P and cytosine, whereas the presence of Ag(+) strongly destabilizes nucleic acids comprising an artificial base pair between P and thymine. …”
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  2. 802
    “…All of the pancreatic cancer cell lines expressed the canonical CXCR4B transcript in addition to the alternatively spliced variant CXCR4A as determined by RT-qPCR experiments. …”
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  3. 803
    “…We here show that RACK1 knockdown induces autophagy independent of upstream canonical factors such as Beclin1, Atg7 and Atg5/12 conjugates. …”
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  4. 804
    “…The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca(2+) selectivity. …”
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  5. 805
    “…The analysis of human datasets and GBM tumors revealed higher expression of p65 in GBM-associated CD68+ macrophages compared to neighboring stroma. Thus, canonical NF-κB signaling has an anti-inflammatory role and is required for macrophage polarization, immune suppression, and GBM growth. …”
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  6. 806
  7. 807
    “…Here, we gather and discuss the evidence on the non-canonical HIF-1α regulation, focusing in particular on the consequences of mitochondrial respiratory complexes damage on stabilization of this pleiotropic transcription factor.…”
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  8. 808
    “…Grouping by sex and areas, the first canonical correlation were 0.51 (p < 0.0001), 0.43 (p < 0.0001), 0.39 (p < 0.0001) and 0.45 (p < 0.0001). …”
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  9. 809
  10. 810
  11. 811
    “…This was accompanied by a significantly reduced expression of genes of the canonical Wnt pathway. Treatment of these cells with erythropoietin further inhibited the canonical Wnt pathway. …”
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  12. 812
    “…This hypothesis is based predominantly on data from vertebrate embryogenesis as well as planarian regeneration and homeostasis, indicating that canonical Wnt (cWnt) signaling endows cells with positional information along the A/P axis. …”
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  13. 813
    por Kokabu, Shoichiro, Rosen, Vicki
    Publicado 2017
    “…Bone morphogenetic protein (BMP) and canonical Wnt (cWnt) signaling factors are both known to regulate bone mass, fracture risk, fracture repair, and osteoblastogenesis. …”
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  14. 814
  15. 815
    “…Collectively, p204 is a critical component of canonical LPS-TLR4 signaling pathway, and these studies also suggest that p204 could be a potential target to prevent and treat inflammatory and infectious diseases.…”
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  16. 816
    por Rolando, Chiara, Taylor, Verdon
    Publicado 2017
    “…In our recent work we found that the RNAaseIII Drosha not only regulates microRNA production, but also directly affects the stability of mRNAs and thereby controls proteome composition. This non-canonical (miRNA-independent) function of Drosha is central in the maintenance and fate choices made by adult hippocampal NSCs in the healthy brain. …”
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  17. 817
  18. 818
    “…Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the spinal cord, and KOR activation attenuated GRPR-mediated histamine-independent acute and chronic itch in mice. Notably, canonical KOR-mediated G(αi) signaling is not required for desensitizing GRPR function. …”
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  19. 819
  20. 820
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