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  1. 861
    “…There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression is reduced in OA patients’ synovia. …”
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    Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis
  2. 862
    “…BACKGROUND: Personalized medicine requires finding relationships between variables that influence a patient’s phenotype and predicting an outcome. Sparse generalized canonical correlation analysis identifies relationships between different groups of variables. …”
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    Multi-omic modelling of inflammatory bowel disease with regularized canonical correlation analysis
  3. 863
    “…Although, the contribution of CD8 T cells to PD-1 blockade therapy has been well-established, recent studies also suggest the involvement of non-canonical PD-1 signaling in blockade therapy. This review discusses the role of non-canonical PD-1 signaling in distinct cell types and explores how the available knowledge can improve PD-1 blockade immunotherapy, particularly in identifying novel biomarkers and combination treatment strategies.…”
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    Non-canonical PD-1 signaling in cancer and its potential implications in clinic
  4. 864
    por Chakafana, Graham, Shonhai, Addmore
    Publicado 2021
    “…Generally, Hsp70s are divided into two main subtypes: canonical Hsp70 (Escherichia coli Hsp70/DnaK homologues) and the non-canonical (Hsp110 and Grp170) members. …”
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    The Role of Non-Canonical Hsp70s (Hsp110/Grp170) in Cancer
  5. 865
    por Zach, Róbert, Carr, Antony M.
    Publicado 2021
    “…Conclusions: Our experiments do not disprove the existence of opportunistic polymerase switches; however, the data indicate that, if stochastic replacement of Polε for Polδ does occur i n vivo, it represents a rare phenomenon that does not significantly influence canonical replication program.…”
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    Increased expression of Polδ does not alter the canonical replication program in vivo
  6. 866
    por Desai, Bijoy J., Gonzalez, Ruben L.
    Publicado 2020
    “…To overcome these limitations, we have developed a general, multiplexed method in which we genomically encode non-canonical amino acids (ncAAs) into multiple, structure-informed, individual sites within a target MBC; select for ncAA-containing MBC variants that assemble and function like the wildtype MBC; and site-specifically conjugate biochemical or biophysical labels to these ncAAs. …”
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    Multiplexed genomic encoding of non-canonical amino acids for labeling large complexes
  7. 867
    “…Canonical transient receptor potential channels (TRPCs) are nonselective, high calcium permeability cationic channels. …”
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    Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials
  8. 868
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    Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update
  9. 869
    “…This leads to consider the “missing tRNA genes” as a source of putative non-canonical tRNA functions and to broaden the concept of adapter molecules in ribosomal-dependent protein synthesis.…”
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    On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?
  10. 870
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    Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics
  11. 871
    por Astudillo, Pablo
    Publicado 2021
    “…However, Wnt5a, regarded as a prototypical non-canonical Wnt ligand, has also been extensively associated with this disease. …”
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    A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer
  12. 872
    por Cho, Yong Suk, Jiang, Jin
    Publicado 2021
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    Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View
  13. 873
    “…Experimental analyses confirmed the expression of the well-known circRNA CDR1as, a canonical circRNA, and a novel i-circRNA in psoriasis. …”
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    Canonical and Interior Circular RNAs Function as Competing Endogenous RNAs in Psoriatic Skin
  14. 874
    “…In the expression analysis, necroptosis and sirtuin signalling pathways, mitochondrial dysfunction, and inflammasome were the top canonical pathways for both TSPOAP1 and TSPO, confirming the close relationship between these two proteins. …”
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    Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases
  15. 875
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    Canonical Grading Scales of Corneal and Conjunctival Staining Based on Psychophysical and Physical Attributes
  16. 876
    “…A stepwise discriminant canonical analysis (DCA) was used to determine genotype clustering patterns. …”
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    Discriminant Canonical Tool for Differential Biometric Characterization of Multivariety Endangered Hen Breeds
  17. 877
    “…One ideal mechanism of protein regulation is the specific installation of a photolabile-protecting group through the use of photocaged non-canonical amino acids. Consequently, PRMT1 was caged at a key tyrosine residue with a nitrobenzyl-protected Schultz amino acid to modulate protein function. …”
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    Photoregulation of PRMT-1 Using a Photolabile Non-Canonical Amino Acid
  18. 878
    “…Additionally, we introduce the non-canonical structures of nucleic acids containing these modifications.…”
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    Non-Canonical Helical Structure of Nucleic Acids Containing Base-Modified Nucleotides
  19. 879
    “…Even if a virus uses the canonical cap-dependent ribosome recruitment, it can still perturb conventional ribosomal scanning and start codon selection. …”
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    Non-Canonical Translation Initiation Mechanisms Employed by Eukaryotic Viral mRNAs
  20. 880
    “…Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the development and progression of colorectal cancer. …”
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    A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
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