Mostrando 921 - 940 Resultados de 23,561 Para Buscar '"canonization"', tiempo de consulta: 0.19s Limitar resultados
  1. 921
  2. 922
    por Dado, Shlomo, Dar, Arnon, De Rujula, A.
    Publicado 2005
    “…The "canonical behaviour" of the early X-ray afterglows of long-duration Gamma-Ray Bursts (GRBs) --observed by the X-Ray Telescope of the SWIFT satellite-- is precisely the one predicted by the Cannonball model of GRBs.…”
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  3. 923
  4. 924
  5. 925
  6. 926
    “…We first assessed nucleotide diversity and extended haplotype homozygosity for canonical immune genes finding the strongest signatures of positive selection acting on genes involved in pathogen recognition and antiviral defense, possibly driven by growing pathogen spread in wild populations. …”
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  7. 927
    “…We have now investigated the role of the sympathetic branch of the autonomic nervous system in this and shown it to have a non-canonical role. In mice, sustained long-term block of cardiac β-adrenergic receptors by propranolol administered in the drinking water abolished the day–night rhythm in pacemaking in the isolated sinus node. …”
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  8. 928
  9. 929
    “…AHR also regulates the development and function of the liver and the immune system. In the canonical pathway, AHR binds a consensus DNA sequence, termed the xenobiotic response element (XRE), recruits protein coregulators, and regulates target gene expression. …”
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  10. 930
    “…Ribosome profiling (Ribo-seq) has proven transformative for our understanding of the human genome and proteome by illuminating thousands of non-canonical sites of ribosome translation outside of the currently annotated coding sequences (CDSs). …”
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  11. 931
    “…Here, we report the in silico identification of compounds that we refer to as non-canonical p38α inhibitors (NC-p38i). By combining biochemical and structural analyses, we show that NC-p38i efficiently inhibit p38α autophosphorylation but weakly affect the activity of the canonical pathway. …”
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  12. 932
    por Denham, Joshua
    Publicado 2023
    “…Seminal findings from 1985 revealed the canonical role of telomerase and motivated investigations into potential therapeutic strategies to combat one of the hallmarks of ageing—telomere attrition. …”
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  13. 933
    “…The crosstalk between canonical Wnt, focal adhesions, lysosomes, and macropinocytosis suggests possible therapeutic targets for cancer progression in Wnt-driven cancers.…”
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  14. 934
    “…Both the canonical Wnt and androgen receptor (AR) signaling pathways are important for prostate organogenesis and homeostasis. …”
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  15. 935
  16. 936
  17. 937
    “…Conclusion: NGS, a more multidimensional and comprehensive gene mutation detection, is required for patients suspected of having MPN to detect non-canonical driver variants and avoid the misdiagnosis of TN MPN. …”
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  18. 938
  19. 939
  20. 940
    “…RESULTS: We show that by controlling GSK3b phosphorylation our three small-molecule inhibitors (SMIs) simultaneously enhance canonical Wnt signaling and potentiate canonical BMP signaling intensity and duration. …”
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