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  1. 1001
    “…The stability of β‐catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3β phosphorylates β‐catenin to be degraded by ubiquitination with β‐TrCP. …”
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    WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
  2. 1002
    “…A concentration test of ternary solutions is carried out to testify its effectiveness, and then Canonical Correlation Analysis is applied to evaluate the data. …”
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    A Multifunctional Sensor in Ternary Solution Using Canonical Correlations for Variable Links Assessment
  3. 1003
    “…Hedgehog(HH) pathway is found to be activated through a manner of canonical, or the non-canonical HH pathways. Distinct hyperplasia stroma around tumor cells is supposed to express pro-inflammatory cytokines abundantly, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), etc. in pancreatic ductal adenocarcinoma (PDAC) tissues. …”
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    Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma
  4. 1004
    “…These results suggest a non-canonical role of IKKα in RLR signaling. Furthermore, phosphorylation of STAT1 was suppressed by IKKα knockdown in cells treated with a specific neutralizing antibody for the type I IFN receptor (IFNAR) and in IFNAR-deficient cells. …”
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    Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling
  5. 1005
    “…The incorporation of non-canonical amino acids (ncAA) is an elegant way for the chemical diversification of recombinantly produced antimicrobial peptides (AMPs). …”
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    Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides
  6. 1006
    “…We show that mouse and human germ cells exhibit non-canonical X dosage states that differ from the soma and between the sexes. …”
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    Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline
  7. 1007
    “…BACKGROUND: Advance in high-throughput technologies in genomics, transcriptomics, and metabolomics has created demand for bioinformatics tools to integrate high-dimensional data from different sources. Canonical correlation analysis (CCA) is a statistical tool for finding linear associations between different types of information. …”
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    Sparse kernel canonical correlation analysis for discovery of nonlinear interactions in high-dimensional data
  8. 1008
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    Ethanol Effects Involve Non-canonical Unfolded Protein Response Activation in Yeast Cells
  9. 1009
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    Editorial: Aurora Kinases: Classical Mitotic Roles, Non-Canonical Functions and Translational Views
  10. 1010
    “…These findings therefore suggest that in this system, kinetochores could be involved in sensing meiotic errors using an unconventional mechanism that does not use canonical end-on attachments.…”
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    Caenorhabditis elegans oocytes detect meiotic errors in the absence of canonical end-on kinetochore attachments
  11. 1011
    por Park, June Hyun, Shin, Chanseok
    Publicado 2017
    “…Based on these results, we propose that non-canonical targets may play an important regulatory role in controlling the stability of miRNAs, instead of being regulated by miRNAs.…”
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    Non-canonical targets play an important role in microRNA stability control mechanisms
  12. 1012
    “…We focus our review on the opposing interactions observed in glioma between the canonical WNT/beta-catenin pathway and PPAR gamma and their metabolic and thermodynamic implications. …”
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    Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma
  13. 1013
    “…Thus, a previously unrecognized, non-canonical GR activation of gilz is involved in alcohol modulation of cell immune response.…”
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    Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response
  14. 1014
    “…To resolve gene interaction between AIDS and complicating diseases, a canonical correlation analysis was used to identify the global correlation between AIDS and other disease pathway genes expression. …”
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    Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis
  15. 1015
    “…Here, a survey of alternative 3΄UTR isoforms implicates a non-canonical seedless site in cooperative miRNA-mediated silencing. …”
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    A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing
  16. 1016
    por Corda, G, Sala, A
    Publicado 2017
    “…Frizzled receptors are the mediators of the wnt canonical and non-canonical pathways, which play fundamental roles in cell differentiation and organism development. …”
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    Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage
  17. 1017
    “…While the cytosolic events of Wnt/β‐catenin signaling (canonical Wnt signaling) pathway have been widely studied, only little is known about the molecular mechanisms involved in Wnt binding to its receptors at the plasma membrane. …”
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    Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments
  18. 1018
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    Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
  19. 1019
    por Wang, Qiyu, Lu, Quan
    Publicado 2017
    “…Here we report that ARMMs contain active NOTCH receptors and mediate a non-canonical intercellular NOTCH signaling. We identify over 100 proteins that are significantly enriched in ARMMs, including ARRDC1, TSG101 and multiple ESCRT complex proteins. …”
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    Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling
  20. 1020
    “…Our comparative genomics analysis therefore supports the secondary acquisition of the Lepidoptera W by a non-canonical mechanism, and it confirms the extreme stability of well-differentiated sex chromosomes.…”
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    The deep conservation of the Lepidoptera Z chromosome suggests a non-canonical origin of the W
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