Materias dentro de su búsqueda.
Mostrando 1,021 - 1,040 Resultados de 23,561 Para Buscar '"canonization"', tiempo de consulta: 0.19s Limitar resultados
  1. 1021
    “…The combination of these alternative pathways and canonical autophagy blockade, results in dramatic nuclear pathology with disruption of the nuclear organization, bringing about terminal cell atrophy and degeneration. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration
  2. 1022
    “…[Image: see text] The ability of grand canonical Monte Carlo (GCMC) to create and annihilate molecules in a given region greatly aids the identification of water sites and water binding free energies in protein cavities. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Replica-Exchange and Standard State Binding Free Energies with Grand Canonical Monte Carlo
  3. 1023
    “…Here, using an engineered organotypic model of perfused microvessels and confirming in mouse models, we identify that activation of the Notch1 transmembrane receptor directly regulates vascular barrier function through a non-canonical, transcription independent signaling mechanism that drives adherens junction assembly. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    A non-canonical Notch complex regulates adherens junctions and vascular barrier function
  4. 1024
    “…Here we demonstrate that RPE degeneration in human cell culture and in mouse models is driven by a non-canonical inflammasome pathway that results in activation of caspase-4 (caspase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-β (IFN-β) production and gasdermin D-dependent interleukin-18 (IL-18) secretion. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    cGAS drives non-canonical inflammasome activation in age-related macular degeneration
  5. 1025
    “…Similarly, only the first canonical function was significant for women (Rc=.36, λ=.87, χ29=33.9, P<.001), which accounted for 13% of the overlapping variance. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Gender Differences in and the Relationships Between Social Anxiety and Problematic Internet Use: Canonical Analysis
  6. 1026
    por Reed, Kevin B., Alper, Hal S.
    Publicado 2017
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Expanding beyond canonical metabolism: Interfacing alternative elements, synthetic biology, and metabolic engineering
  7. 1027
    “…Gene regulatory network (GRN) analysis demonstrated Mtf2 directly regulates Wnt signaling in erythroblasts, leading to activated canonical Wnt signaling in Mtf2-deficient erythroblasts, while chemical inhibition of canonical Wnt signaling rescued Mtf2-deficient erythroblast differentiation in vitro. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis
  8. 1028
    “…Mirtrons are non-canonical microRNAs encoded in introns the biogenesis of which starts with splicing. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Distinguishing mirtrons from canonical miRNAs with data exploration and machine learning methods
  9. 1029
    “…Rather, in these intact systems succinate primarily originates from canonical Krebs cycle activity, partly supported by aminotransferase anaplerosis and glycolysis from glycogen. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity
  10. 1030
    “…The medicinal suggestions for CTS in the Canon of Medicine will be good candidates for discovering new treatments besides providing historical significance to the various insights considered 1000 years ago.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    New candidates for treatment and management of carpal tunnel syndrome based on the Persian Canon of Medicine
  11. 1031
    “…In addition, we demonstrate that Aβ treatment interrupts canonical Shh signal transduction. CONCLUSIONS: Overall, our study illustrates that Aβ can alter primary cilia structure suggesting that elevated Aβ levels, like those observed in AD patients, could have similar effects on neuronal primary cilia in the brain. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
  12. 1032
    “…The current minireview summarizes recent advances in the mechanistic understanding and subsequent precision engineering of canonical mPKS domains, focusing largely on developments in the past year.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects
  13. 1033
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells
  14. 1034
    “…We demonstrate that, at double-strand breaks, increased RECQ5 levels inhibited canonical homology-directed repair (HDR) by double-stranded DNA donors, phenocopying the effect of BRCA deficiency. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways
  15. 1035
    por Lee, Hangnoh, Oliver, Brian
    Publicado 2018
    “…CONCLUSIONS: Our results suggest that this non-canonical dosage compensation is due to the same transacting derepression that occurs on autosomes. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains
  16. 1036
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Evidence for Weyl fermions in a canonical heavy-fermion semimetal YbPtBi
  17. 1037
    por Münz, Christian
    Publicado 2018
    “…In this review, I will discuss the respective studies and how these alternative pathways of macroautophagy protein usage differ from their canonical functions. A better understanding of these additional functions of the macroautophagy machinery should allow us to interpret biological effects of macroautophagy protein deficiencies more comprehensively and to therapeutically target the different pathways which utilize the molecular machinery of macroautophagy.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Non-canonical Functions of Macroautophagy Proteins During Endocytosis by Myeloid Antigen Presenting Cells
  18. 1038
    “…Moreover, the simulations suggest that the crowder interactions narrow the conformational sampling to canonical regions of the conformational space. CONCLUSIONS: The overall conclusion is that crowding effects may stabilize the canonical features of DNA that are most important for biological function. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Role of protein interactions in stabilizing canonical DNA features in simulations of DNA in crowded environments
  19. 1039
    “…Specialized databases support investigation of this issue based on experimental data, and several programs can annotate non-canonical base pairs in the RNA 3D structure. However, predicting the extended RNA secondary structure which describes both canonical and non-canonical interactions remains difficult. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    RNAvista: a webserver to assess RNA secondary structures with non-canonical base pairs
  20. 1040
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection
Herramientas de búsqueda: RSS