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  1. 1181
    “…Unlike DNA, in addition to the 2′-OH group, uracil nucleobase and its modifications play essential roles in structure and function diversities of non-coding RNAs. Non-canonical U•U base pair is ubiquitous in non-coding RNAs, which are highly diversified. …”
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    Structural insights of non-canonical U•U pair and Hoogsteen interaction probed with Se atom
  2. 1182
    “…The 20 canonical amino acids of the genetic code have been invariant over 3 billion years of biological evolution. …”
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    Mutations Enabling Displacement of Tryptophan by 4-Fluorotryptophan as a Canonical Amino Acid of the Genetic Code
  3. 1183
    “…We compared our results with published methods on the E. histolytica proteome scan, and demonstrated our method to be more specific and accurate for predicting potential canonical Ca(2+)-binding loops. Furthermore, we annotated canonical EF-hand motifs and classified them based on their Ca(2+)-binding affinities using support vector machines. …”
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    Prediction and Analysis of Canonical EF Hand Loop and Qualitative Estimation of Ca(2+) Binding Affinity
  4. 1184
    “…It has been reported that NAG sequences are the predominant non-canonical PAM for CCMDC at the human EMX locus, but it is not clear whether it is universal at other loci. …”
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    Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells
  5. 1185
    “…Together, our results suggest that lead has a negative impact on spine outgrowth in the developing hippocampus through altering the canonical Wnt pathway.…”
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    Developmental Lead Exposure Alters Synaptogenesis through Inhibiting Canonical Wnt Pathway In Vivo and In Vitro
  6. 1186
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    Non-Canonical Roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in Epithelial Tube Size Control
  7. 1187
    “…Here we show that Wnt4 attenuated bone loss in osteoporosis and skeletal aging by inhibiting nuclear factor-kappa B (NF-κB) via non-canonical Wnt signaling. Transgenic mice expressing Wnt4 from osteoblasts were significantly protected from bone loss and chronic inflammation induced by ovariectomy, tumor necrosis factor or natural aging. …”
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    Non-canonical Wnt4 prevents skeletal aging and inflammation by inhibiting NF-κB
  8. 1188
    “…Despite the fact that signal propagation in the adult hippocampus is strongly unidirectional through the canonical trisynaptic circuit (dentate gyrus [DG] to CA3 to CA1), spontaneous GNA in the developing hippocampus originates in distal CA3 and propagates both forward to CA1 and backward to DG. …”
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    Bidirectional global spontaneous network activity precedes the canonical unidirectional circuit organization in the developing hippocampus
  9. 1189
    por Noort, Ae R, Tak, Paul P, Tas, Sander W
    Publicado 2015
    “…NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. …”
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    Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?
  10. 1190
    por Al-Sebaei, Maisa O
    Publicado 2015
    “…Using a caliper, three neoclassical facial canons were measured; the vertical thirds of the face, the orbital canon (intercanthal distance = eye fissure length), and the orbito-nasal canon (intercanthal distance = nasal width) and analyzed using Student’s t-test, general linear modeling, and pairwise comparison of means. …”
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    The validity of three neo-classical facial canons in young adults originating from the Arabian Peninsula
  11. 1191
    “…We show in this study that, besides participating in this canonical dicer-dependent RNA interference (RNAi) pathway, the rdrp genes are involved in a novel dicer-independent degradation process of endogenous mRNAs. …”
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    A Non-canonical RNA Silencing Pathway Promotes mRNA Degradation in Basal Fungi
  12. 1192
    “…We conclude that the peak and decline behavior of Aktp(308) is caused by a non-canonical effect that retains Akt at the membrane, and not by receptor internalization. …”
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    Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway Dynamics
  13. 1193
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    Reassignment of a rare sense codon to a non-canonical amino acid in Escherichia coli
  14. 1194
    “…The hallmark of the canonical pathway is the activation of β-catenin mediated transcriptional activity. …”
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    The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies
  15. 1195
    “…These variants lie outside the canonical MBD and TRD domains, where the pathogenicity of missense variants is more difficult to establish. …”
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    MECP2 missense mutations outside the canonical MBD and TRD domains in males with intellectual disability
  16. 1196
    por Seth, Chandan, Ruiz i Altaba, Ariel
    Publicado 2016
    “…Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. …”
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    Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling
  17. 1197
    “…Here we show that endothelial non-canonical Wnt signalling regulates endothelial sensitivity to shear forces. …”
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    Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling
  18. 1198
    “…Here, we define WNT5A, a non-canonical Wnt ligand implicated in epithelial differentiation, repair, and cancer, as a direct transcriptional target that is activated by KLF4 in squamous epithelial cells. …”
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    KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification
  19. 1199
    “…In conclusion, we identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.…”
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    Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor
  20. 1200
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    Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters
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