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1241por Laishram, Rakesh S.“…In addition, several non-canonical PAPs have been identified with diverse cellular functions. …”
Publicado 2014
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1242“…Suppressing canonical NOD-like receptor protein 3 (NLRP3) inflammasome-mediated interleukin (IL)-1β secretion is a reliable strategy for the development of nutraceutical to prevent chronic inflammatory diseases. …”
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1243por Ramakrishnan, Sadeesh K., Zhang, Huabing, Ma, Xiaoya, Jung, Inkyung, Schwartz, Andrew J., Triner, Daniel, Devenport, Samantha N., Das, Nupur K., Xue, Xiang, Zeng, Melody Y., Hu, Yinling, Mortensen, Richard M., Greenson, Joel K, Cascalho, Marilia, Wobus, Christiane E., Colacino, Justin A., Nunez, Gabriel, Rui, Liangyou, Shah, Yatrik M.“…Our work thus defines an important function of non-canonical NFkB and M-cells in immune homeostasis, inflammation and polymicrobial sepsis.…”
Publicado 2019
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1244por Arandjelovic, Sanja, Perry, Justin S.A., Lucas, Christopher D., Penberthy, Kristen K., Kim, Tae-Hyoun, Zhou, Ming, Rosen, Dorian A, Chuang, Tzu-Ying, Bettina, Alexandra M., Shankman, Laura S., Cohen, Amanda H., Gaultier, Alban, Conrads, Thomas P., Kim, Minsoo, Elliott, Michael R., Ravichandran, Kodi S.“…These data identify ‘non-canonical’ roles for ELMO1 as an important cytoplasmic regulator of specific neutrophil receptors and promoter of arthritis.…”
Publicado 2019
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1245por Corada, Monica, Orsenigo, Fabrizio, Bhat, Ganesh Parameshwar, Conze, Lei Liu, Breviario, Ferruccio, Cunha, Sara Isabel, Claesson-Welsh, Lena, Beznoussenko, Galina V., Mironov, Alexander A., Bacigaluppi, Marco, Martino, Gianvito, Pitulescu, Mara E., Adams, Ralf H., Magnusson, Peetra, Dejana, Elisabetta“…RATIONALE: The microvasculature of the central nervous system includes the blood-brain barrier (BBB), which regulates the permeability to nutrients and restricts the passage of toxic agents and inflammatory cells. Canonical Wnt/β-catenin signaling is responsible for the early phases of brain vascularization and BBB differentiation. …”
Publicado 2019
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1246“…Here we show that suppression of ALN paternal allele expression is imposed by non-canonical RNA-directed DNA methylation (RdDM) of the paternal ALN allele promoter. …”
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1247por Li, Jiao, Huang, Kaimeng, Hu, Gongcheng, Babarinde, Isaac A., Li, Yaoyi, Dong, Xiaotao, Chen, Yu-Sheng, Shang, Liping, Guo, Wenjing, Wang, Junwei, Chen, Zhaoming, Hutchins, Andrew P., Yang, Yun-Gui, Yao, Hongjie“…Taken together, this study reveals a non-canonical function for CTCF-s that antagonizes the genomic binding of canonical CTCF and cohesin, and that modulates chromatin looping and causes apoptosis by stimulating IFI6 expression.…”
Publicado 2019
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1249por Jeong, SeungJoo, Ko, Juyeon, Kim, Minji, Park, Ki Chul, Park, Eunice Yon June, Kim, Jinsung, Baik, Youngjoo, Wie, Jinhong, Cho, Art E., Jeon, Ju-hong, So, Insuk“…The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. …”
Publicado 2019
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1250por Shawber, Carrie J., Brown-Grant, Dex-Ann, Wu, Tracy, Kitajewski, Jan K., Douglas, Nataki C.“…Our data suggest that mouse placentation occurs normally despite dominant negative inhibition of trophoblast canonical Notch signaling and that Notch2 signaling via the canonical pathway is not necessary for placentation.…”
Publicado 2019
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1251por Singh, Ratnakar, Peng, Shaohua, Viswanath, Pavitra, Sambandam, Vaishnavi, Shen, Li, Rao, Xiayu, Fang, Bingliang, Wang, Jing, Johnson, Faye MEnlace del recurso
Publicado 2019
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1252por Vicario, Nunzio, Bernstock, Joshua D., Spitale, Federica M., Giallongo, Cesarina, Giunta, Maria A.S., Li Volti, Giovanni, Gulisano, Massimo, Leanza, Giampiero, Tibullo, Daniele, Parenti, Rosalba, Gulino, Rosario“…Moreover, cellular thermal shift assay suggested that clobetasol induces the canonical Smo-dependent activation of Shh signaling, as confirmed by Gli1 nuclear translocation and also by cyclopamine co-treatment, which abolished these effects. …”
Publicado 2019
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1253Reading canonical and modified nucleobases in 16S ribosomal RNA using nanopore native RNA sequencing“…Nanopore ionic current traces that deviated from canonical patterns revealed conserved E. coli 16S rRNA 7-methylguanosine and pseudouridine modifications, and a 7-methylguanosine modification that confers aminoglycoside resistance to some pathological E. coli strains.…”
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1254“…Often, in a given cancer type canonical and non-canonical activation of HH-GLI signaling co-exist, and in some cancer types, more than one mechanism of non-canonical activation may occur. …”
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1256por Su, Tsung-Ping“…However, those “non-canonical” targets of drugs of abuse, in general, have not been widely recognized in drug abuse research. …”
Publicado 2019
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1257por Carvalho, Joana R, Fortunato, Isabela C, Fonseca, Catarina G, Pezzarossa, Anna, Barbacena, Pedro, Dominguez-Cejudo, Maria A, Vasconcelos, Francisca F, Santos, Nuno C, Carvalho, Filomena A, Franco, Claudio A“…Our findings highlight how non-canonical Wnt signaling coordinates collective cell behavior during vascular morphogenesis by fine-tuning junctional mechanocoupling between endothelial cells.…”
Publicado 2019
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1258por Cai, Bi-He, Chao, Chung-Faye, Huang, Hsiang-Chi, Lee, Hsueh-Yi, Kannagi, Reiji, Chen, Jang-Yi“…The p53 canonical consensus sequence is a 10-bp repeat of PuPuPuC(A/T)(A/T)GPyPyPy, separated by a spacer with up to 13 bases. …”
Publicado 2019
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1259por Walker, Catriona H., Siu-Ting, Karen, Taylor, Alysha, O’Connell, Mary J., Bennett, Tom“…CONCLUSIONS: Overall, our results suggest that SL synthesis is much more ancient than canonical SL signalling, consistent with the idea that SLs first evolved as rhizosphere signals and were only recruited much later as hormonal signals. …”
Publicado 2019
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1260por Tang, Peter H., Velez, Gabriel, Tsang, Stephen H., Bassuk, Alexander G., Mahajan, Vinit B.“…PURPOSE: To gain insight into the pathophysiology of vitreoretinal degeneration, the clinical course of three family members with Versican Vitreoretinopathy (VVR) is described, and a canonical splice site mutation in the gene encoding for versican (VCAN) protein was biochemically analyzed. …”
Publicado 2019
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