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  1. 1261
    “…Extensive studies in vertebrate models have strongly implicated the non-canonical Wnt/planar cell polarity (PCP) signaling pathway in the pathogenesis of NTDs. …”
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    Update on the Role of the Non-Canonical Wnt/Planar Cell Polarity Pathway in Neural Tube Defects
  2. 1262
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    Corrigendum: Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia
  3. 1263
    “…Collectively, our studies reveal a non-canonical pathway underlying PS externalization and cell death in AML to provide mechanistic insight into the antitumor properties of FTY720.…”
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    FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
  4. 1264
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    Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion
  5. 1265
    “…While AB and CB, respectively, activated transient or sustained canonical cKIT-signaling, PV showed a non-canonical signaling including increased mTOR and ERK1 and decreased DEPTOR. …”
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    Phosphoproteomic Landscaping Identifies Non-canonical cKIT Signaling in Polycythemia Vera Erythroid Progenitors
  6. 1266
    “…Our results suggest that targeting the non-canonical roles of PCNA in cellular signaling have the potential to improve targeted therapies.…”
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    Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
  7. 1267
    “…Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune responses. …”
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    Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
  8. 1268
    “…Inhibition of transient receptor potential channel canonical type 3 (TRPC3) attenuates mitochondrial calcium handling and ROS production in the vasculature of hypertensive rats. …”
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    Transient Receptor Potential Channel Canonical Type 3 Deficiency Antagonizes Myofibroblast Transdifferentiation In Vivo
  9. 1269
    “…Additionally, we reconstruct the kinetics and probabilities of the conformational transitions between canonical clusters, and thereby extend the model of static canonical structures to reveal a dynamic conformational ensemble in solution as a new paradigm in the field of antibody structure design. …”
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    Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures
  10. 1270
    por Yi, Young-Su
    Publicado 2020
    “…New types of inflammasomes have been recently discovered and named as ‘non-canonical’ inflammasomes since their roles to induce inflammatory responses are similar to those of canonical inflammasomes, however, the stimulating ligands and the underlying mechanisms are different. …”
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    Caspase-11 Non-Canonical Inflammasome: Emerging Activator and Regulator of Infection-Mediated Inflammatory Responses
  11. 1271
    “…Canonical prefoldin is a protein cochaperone composed of six different subunits (PFDN1 to 6). …”
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    Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer
  12. 1272
    “…Here, we identify a non-canonical promoter element that plays a key role. The sequence, itself a short AT-tract, resides 5 base pairs upstream of otherwise cryptic -10 elements. …”
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    A non-canonical promoter element drives spurious transcription of horizontally acquired bacterial genes
  13. 1273
    “…These data show that the placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.…”
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    Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
  14. 1274
    “…Our study is a retrospective secondary analysis that re-analyzed resting-state functional magnetic resonance imaging of 284 participants from the enhanced Nathan Kline Institute-Rockland Sample database. Leveraging sparse canonical correlation analysis, we associated the functional connectivity of all brain regions and all questions in the eating disorder questionnaires. …”
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    Multivariate association between brain function and eating disorders using sparse canonical correlation analysis
  15. 1275
    por Robic, Annie, Kühn, Christa
    Publicado 2020
    “…Most of the circRNAs reported to date originate from back splicing of a pre-mRNA, and these exonic circRNAs are termed canonical circRNAs. Our objective was to provide an overview of all other (non-canonical) circRNAs that do not originate from the junction of two exons and to characterize their common properties. …”
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    Beyond Back Splicing, a Still Poorly Explored World: Non-Canonical Circular RNAs
  16. 1276
    “…Children with neurodevelopmental disorders (NDDs) share common behavioural manifestations despite distinct categorical diagnostic criteria. Here, we examined canonical resting-state network connectivity in three diagnostic groups (autism spectrum disorder, attention-deficit/hyperactivity disorder and paediatric obsessive–compulsive disorder) and typically developing controls (TD) in a large single-site sample (N = 407), applying diagnosis-based and dimensional approaches to understand underlying neurobiology across NDDs. …”
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    Beyond diagnosis: Cross-diagnostic features in canonical resting-state networks in children with neurodevelopmental disorders
  17. 1277
    “…To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). …”
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    Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer
  18. 1278
    “…Analysis of ~50,000 UV-induced mutations reveals abundant non-canonical mutations, including T>C, T>A, and AC>TT substitutions. …”
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    Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma
  19. 1279
    “…Results: Two statistically significant (p < 0.05) canonical coefficients were found, with the first canonical correlation coefficient having a value of 0.247, eigenvalue of 0.065, and contribution rate of 89.0%. …”
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    Canonical Correlation Analysis on the Association Between Sleep Quality and Nutritional Status Among Centenarians in Hainan
  20. 1280
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    Insect‐Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non‐Canonical Polyketide Chain Termination
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