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  1. 1281
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    FAM83F regulates canonical Wnt signalling through an interaction with CK1α
  2. 1282
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    Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages
  3. 1283
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    Rapid Structural Analysis of a Synthetic Non-canonical Amino Acid by Microcrystal Electron Diffraction
  4. 1284
    por Horie, Kana, Ma, Jun, Umezawa, Kazuo
    Publicado 2015
    “…However, it was not elucidated for p65, a main canonical NF-κB component. In the present research, we studied how (−)-DHMEQ inhibits nuclear localization of p65. …”
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    Inhibition of Canonical NF-κB Nuclear Localization by (−)-DHMEQ via Impairment of DNA Binding
  5. 1285
    “…We show that in P. falciparum that lacks the H2A.X variant, the canonical P. falciparum H2A (PfH2A) is phosphorylated on serine 121 upon exposure to sources of DNA damage. …”
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    Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites
  6. 1286
    “…Activation of gene expression by TH action is canonically ascribed to a hormone-dependent “switch” from corepressor to activator binding to thyroid hormone receptors (TRs), while the mechanism of TH-dependent repression is controversial. …”
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    A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver
  7. 1287
    “…SEC23B encodes SEC23 homologue B, a component of coat protein complex II (COPII), which canonically transports proteins from the endoplasmic reticulum (ER) to the Golgi. …”
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    Non-canonical role of wild-type SEC23B in the cellular stress response pathway
  8. 1288
    “…Methods: We examined the serum, salivary and bone samples from Pre- and Post-menopause women by paired analysis and confirmed canonical ceRNA role of MIR143HG and miR-143/145 complexes in cytoplasm and noncanonical role for SOX2 transcription in nucleus (FISH, qRT-PCR, immunostaining, Luciferase assays and ChIP). …”
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    Identification of the canonical and noncanonical role of miR-143/145 in estrogen-deficient bone loss
  9. 1289
    “…The proposed method uses discriminant canonical correlation analysis (DCCA) feature fusion. …”
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    Automated Atrial Fibrillation Detection Based on Feature Fusion Using Discriminant Canonical Correlation Analysis
  10. 1290
    “…Downregulation of Ryk in MSCs decreased their clonogenic activity and ability to support self-renewing expansion of primitive hematopoietic progenitors (HPCs) in response to canonical Wnt ligands. In contrast, under high concentrations of Wnt, Ryk exerted suppressive effects on the transactivation of target genes and HPC-supporting effects in MSCs, thus fine-tuning the signaling intensity of Wnt in BM stromal cells. …”
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    Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
  11. 1291
    por Chen, Hong-Bin, Chen, Yueh-Nan
    Publicado 2021
    “…A recent proposed idea which studies the representation of dynamical processes in the frequency domain, referred to as canonical Hamiltonian ensemble representation (CHER), proved its capability of characterizing the noncalssical traits of the dynamics. …”
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    Canonical Hamiltonian ensemble representation of dephasing dynamics and the impact of thermal fluctuations on quantum-to-classical transition
  12. 1292
    “…Our findings indicate that non-canonical mechanisms of Hh signaling are necessary for spinal cord and muscle regeneration.…”
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    Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae
  13. 1293
    “…However, some geometrical features and non-canonical DNA structures severely impaired its activity, suggesting a relevant role of misincorporated ribonucleotides in the physiological instability of specific DNA sequences.…”
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    High Flexibility of RNaseH2 Catalytic Activity with Respect to Non-Canonical DNA Structures
  14. 1294
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    Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells
  15. 1295
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    Prickle morphogenesis in rose is coupled with secondary metabolite accumulation and governed by canonical MBW transcriptional complex
  16. 1296
    “…Here, we propose sparse canonical correlation analysis for cancer classification (SCCA-CC), which projects each type of single-omics data onto a unified space for data fusion, followed by clustering and classification analysis. …”
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    Multi-Omics Data Fusion for Cancer Molecular Subtyping Using Sparse Canonical Correlation Analysis
  17. 1297
    “…To explore Sr(2+) interference with Ca(2+) binding to proteins of the EF-hand family, we studied Sr(2+)/Ca(2+) interaction with a canonical EF-hand protein, α-parvalbumin (α-PA). Evaluation of the equilibrium metal association constants for the active Ca(2+) binding sites of recombinant human α-PA (‘CD’ and ‘EF’ sites) from fluorimetric titration experiments and isothermal titration calorimetry data gave 4 × 10(9) M(−1) and 4 × 10(9) M(−1) for Ca(2+), and 2 × 10(7) M(−1) and 2 × 10(6) M(−1) for Sr(2+). …”
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    Strontium Binding to α-Parvalbumin, a Canonical Calcium-Binding Protein of the “EF-Hand” Family
  18. 1298
    por Mahony, Caitlyn, O’Ryan, Colleen
    Publicado 2021
    “…These proteins converge on protein–protein interaction networks that regulate cell proliferation and differentiation, metabolism, and inflammation, which demonstrates a link between canonical pathways, biological processes and the ASD phenotype. …”
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    Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation Data
  19. 1299
    “…The non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is an important component of NF-κB transcription complex. …”
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    Interplay Between Non-Canonical NF-κB Signaling and Hepatitis B Virus Infection
  20. 1300
    “…Thus, astrocytic Nrf2 activation by oxidative stress involves Keap1-independent non-canonical signaling, meaning that further Nrf2 activation by Keap1-inhibiting drugs may be a viable therapeutic strategy.…”
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    Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
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