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1301“…Particularly the non-canonical nuclear-localized HO-1 and HO-1 protein interactions play the role of a warrior against oxidative stress. …”
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1302por Bley, Isabelle Ariane, Zwick, Anabel, Hans, Muriel Charlotte, Thieser, Katrin, Wagner, Viktoria, Ludwig, Nicole, Khalmurzaev, Oybek, Matveev, Vsevolod Borisovich, Loertzer, Philine, Pryalukhin, Alexey, Hartmann, Arndt, Geppert, Carol-Immanuel, Loertzer, Hagen, Wunderlich, Heiko, Naumann, Carsten Maik, Kalthoff, Holger, Junker, Kerstin, Smola, Sigrun, Lohse, Stefan“…While gene expression analyses suggested an augmented and active canonical Wnt pathway, the respective signaling was inhibited due to the endogenous expression of the antagonist DKK1. …”
Publicado 2021
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1303por Constantino, Flávia Bessi, Cury, Sarah Santiloni, Nogueira, Celia Regina, Carvalho, Robson Francisco, Justulin, Luis Antonio“…Despite low levels of the canonical cell entry mediators ACE2 and TMPRSS2, we show that cells of the syncytiotrophoblast, villous cytotrophoblast, and extravillous trophoblast co-express high levels of the potential non-canonical cell-entry mediators DPP4 and CTSL. …”
Publicado 2021
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1304por Hinman, Amelia E, Jani, Charul, Pringle, Stephanie C, Zhang, Wei R, Jain, Neharika, Martinot, Amanda J, Barczak, Amy K“…Expression of the later component was inherent to TLR2 activation, dependent upon endosomal uptake, and enhanced by phagosome acidification. Canonical Mtb virulence factors that contribute to phagosomal membrane damage blunted phagosome acidification and undermined the endosome-specific response. …”
Publicado 2021
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1305“…Our findings highlight the role of non-canonical Wnt signaling in regeneration of the intestinal epithelium, and identify enteroendocrine cell-released ligands as critical coordinators of intestinal stem cell migration.…”
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1306por Mareninova, Olga A., Dillon, Dustin L., Wightman, Carli J.M., Yakubov, Iskandar, Takahashi, Toshimasa, Gaisano, Herbert Y., Munson, Keith, Ohmuraya, Masaki, Dawson, David, Gukovsky, Ilya, Gukovskaya, Anna S.“…Canonical autophagy is essential for exocrine pancreas homeostasis, and its disordering initiates and drives pancreatitis. …”
Publicado 2021
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1307“…Abnormal iron levels are linked to neurodegenerative diseases, liver injury, cancer, and ocular diseases. Canonical Wnt signaling is an evolutionarily conserved signaling pathway that regulates many cellular functions including cell proliferation, apoptosis, cell migration, and stem cell renewal. …”
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1308por Zhao, Yi, Miranda Herrera, Pierre A., Chang, Dalu, Hamelin, Romain, Long, Marcus J. C., Aye, Yimon“…In a setup that contrasts nucleus- vs. cytoplasm-specific responsivity to reactive-metabolite modification (hydroxynonenylation), ∼40% of the top-enriched protein sensors investigated respond in compartments of nonprimary origin or where the canonical activity of the protein sensor is inoperative. …”
Publicado 2022
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1309por Wen, Ying, Wang, Ying, Chen, Shouwen, Zhou, Xiangshan, Zhang, Yuanxing, Yang, Dahai, Núñez, Gabriel, Liu, Qin“…Collectively, our results reveal a novel non-canonical ferroptosis pathway mediated by bacterial c-di-GMP and provide evidence for a role of ferroptosis in the regulation of pathogen infection.…”
Publicado 2022
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1310por Hu, Xiaoxiao, Lin, Chensheng, Ruan, Ningsheng, Huang, Zhen, Zhang, Yanding, Hu, Xuefeng“…In this study, we investigated whether this atypical BMP canonical signaling is conserved in human odontogenesis. …”
Publicado 2022
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1311“…We speculate on the existence of novel genes downstream and upstream of the canonical cell death pathways relevant to neuronal biology. …”
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1312por Bose, Mukulika, Grover, Priyanka, Sanders, Alexa J., Zhou, Ru, Ahmad, Mohammad, Shwartz, Sophia, Lala, Priyanka, Nath, Sritama, Yazdanifar, Mahboubeh, Brouwer, Cory, Mukherjee, Pinku“…We hypothesized that MUC1 overexpression induces TGF-β mediated non-canonical signaling pathways which is known to be associated with poor prognosis. …”
Publicado 2022
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1313“…Over the last decades, numerous examples have involved nuclear non-coding RNAs (ncRNAs) in the regulation of gene expression. ncRNAs can interact with the genome by forming non-canonical nucleic acid structures such as R-loops or DNA:RNA triplexes. …”
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1314Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signalingpor Xu, Liang, Wu, Junguo, Yu, Yueming, Li, Haoran, Sun, Shiwei, Zhang, Tieqi, Wang, Minghai“…Furthermore, overexpression of Dok5 promoted the proliferation and osteogenesis and activated the canonical Wnt/β-catenin signaling pathway. CONCLUSION: Dok5 may regulate the osteogenic proliferation and differentiation via the canonical Wnt/β-catenin signaling pathway.…”
Publicado 2022
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1315por Ye, Li, Cao, Ling, Zhao, Xuemei, Guo, Xinya, Ye, Kangzhuo, Jiao, Sibo, Wang, Yu, He, Xiaoxue, Dong, Chunxing, Hu, Bin, Deng, Fang, Zhao, Heming, Zheng, Ping, Aslam, Mohammad, Qin, Yuan, Cheng, Yan“…Moreover, the BiFC analysis of protein interactions among the central JA-signaling regulators showed that AcJAZ4, AcMYC2, AcNINJA, and AcJAM1 could interact with AcJAZ5 and AcJAZ13 in vivo, indicating a canonical JA-signaling pathway in pineapple. These results increase our understanding of the functions of AcJAZs and the responses of the core players in the JA-signaling pathway to abiotic stresses.…”
Publicado 2022
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1316por Burley, Thomas A., Kennedy, Emma, Broad, Georgia, Boyd, Melanie, Li, David, Woo, Timothy, West, Christopher, Ladikou, Eleni E., Ashworth, Iona, Fegan, Christopher, Johnston, Rosalynd, Mitchell, Simon, Mackay, Simon P., Pepper, Andrea G. S., Pepper, Chris“…Co-culture on CD40L-expressing cells induced both canonical and non-canonical subunit expression in nuclear extracts, which promoted in vitro resistance against fludarabine and ABT-199 (venetoclax) but not CW15337. …”
Publicado 2022
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1317“…Moreover, macrophages can also target intracellular bacteria by pore-forming toxin-induced non-canonical autophagy (PINCA), a recently described non-canonical autophagy pathway, which is activated by phagosomal damage induced by bacteria-derived pore-forming toxins. …”
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1318“…Besides, the presence of non-canonical proteins devoid of a predicted signal peptide in cell wall proteomes is discussed in relation to the possible existence of alternative secretion pathways.…”
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1319
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1320por Chen, Ting-An, Lin, Kun-Yang, Yang, Shun-Min, Tseng, Chen-Yuan, Wang, Yu-Ting, Lin, Chi-Hung, Luo, Lichao, Cai, Yu, Hsu, Hwei-Jan“…Our results reveal a role for canonical Wnt signaling in specifying the ovarian somatic cells necessary for germ cell differentiation. …”
Publicado 2022
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