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  1. 1341
    “…Lipopolysaccharide (LPS)-primed macrophages were treated with a trigger of NLRP3, NLRC4, AIM2, or non-canonical (NC) inflammasomes in the presence of maltol. …”
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    Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation
  2. 1342
    “…In addition to classical m6A modifications, non-canonical type I enzymes catalyze both m6A and m4C using alternative DNA-modification subunits M1 and M2. …”
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    Molecular insights into DNA recognition and methylation by non-canonical type I restriction-modification systems
  3. 1343
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    A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation
  4. 1344
    “…Furthermore, infarct size was reduced in the hearts of TRα(GS) mice that lack canonical TRα signaling but maintain noncanonical TRα action. …”
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    Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics—Role of Canonical Thyroid Hormone Receptor Alpha Signaling
  5. 1345
    Publicado 2022
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    Correction: Insights from analyses of low complexity regions with canonical methods for protein sequence comparison
  6. 1346
    “…Based on the modeling, we suggested classification of the structural differences between canonical proteins and isoforms. Altogether, we can conclude that a majority of isoforms, similarly to the canonical proteins are under selective pressure for the functional roles.…”
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    The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis
  7. 1347
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    Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma
  8. 1348
    “…Tumor microenvironment stress leads to canonical and noncanonical endoplasmic stress (ER) responses, which mediate autophagy and are engaged during proteotoxic challenges to clear unfolded or misfolded proteins and damaged organelles to mitigate stress. …”
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    Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy
  9. 1349
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    Nutrient Signaling, Stress Response, and Inter-organelle Communication Are Non-canonical Determinants of Cell Fate
  10. 1350
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    Antimicrobial Activity and Immunomodulatory Properties of Acidocin A, the Pediocin-like Bacteriocin with the Non-Canonical Structure
  11. 1351
    “…Here we tested the performance of Normalized Canonical Correlation Analysis (NCCA), a frequency-normalized version of CCA, to quantify SSVEP from wearable EEG data with stimulation frequencies ranging from 1 to 10 Hz. …”
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    Efficient Low-Frequency SSVEP Detection with Wearable EEG Using Normalized Canonical Correlation Analysis
  12. 1352
    “…METHODS: In this paper, we demonstrate an innovative use of sparse canonical correlation analysis (sCCA) to effectively identify the ensemble of CNAs, and gene modules in the context of binary and censored disease endpoints. …”
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    Sparse canonical correlation to identify breast cancer related genes regulated by copy number aberrations
  13. 1353
    “…Together, our results reveal the role of mtRF1 in translation termination at non-canonical stop codons in mitochondria.…”
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    Human mitochondria require mtRF1 for translation termination at non-canonical stop codons
  14. 1354
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    Clinical impact of clonal hematopoiesis on severe COVID-19 patients without canonical risk factors
  15. 1355
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    Dual incorporation of non-canonical amino acids enables production of post-translationally modified selenoproteins
  16. 1356
    “…The S. pombe orthologue of the human PAXT connection, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex that targets cryptic unstable transcripts (CUTs) to the nuclear RNA exosome for degradation. It encompasses the canonical poly(A) polymerase Pla1, responsible for polyadenylation of nascent RNA transcripts as part of the cleavage and polyadenylation factor (CPF/CPSF). …”
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    Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
  17. 1357
    “…However, exploration of the niche differentiation of canonical nitrifiers and comammox Nitrospira and their ecological importance in agroecosystems is still limited. …”
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    Differential responses of canonical nitrifiers and comammox Nitrospira to long-term fertilization in an Alfisol of Northeast China
  18. 1358
    “…To address this issue, here, we combine GCMC with nonequilibium candidate Monte Carlo (NCMC) to yield a method that we refer to as grand canonical nonequilibrium candidate Monte Carlo (GCNCMC), in which the water insertions and deletions are carried out in a gradual, nonequilibrium fashion. …”
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    Enhanced Grand Canonical Sampling of Occluded Water Sites Using Nonequilibrium Candidate Monte Carlo
  19. 1359
    por Sun, Ziqiao, Lei, Xin-Gen
    Publicado 2023
    “…However, there is little information on its non-canonical role and metabolic implications. Using a protein complementation assay (PCA) and pull-down assay, we revealed novel protein–protein interactions (PPIs) between SOD1 and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) or epsilon (YWHAE) in this research. …”
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    Evidence and Metabolic Implications for a New Non-Canonical Role of Cu-Zn Superoxide Dismutase
  20. 1360
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    TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer
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