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  1. 1381
    “…We found that the ability of IKBKB to phosphorylate endogenous huntingtin S13 is mediated through a non-canonical interferon regulatory factor3–mediated IKK pathway, distinct from the established involvement of IKBKB in mutant huntingtin’s pathological mechanisms mediated via the canonical pathway. …”
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    IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway
  2. 1382
    “…Surprisingly we find that mutations in all three canonical E2Fs do not hinder the cell cycle, but similarly to RBR silencing, result in hyperplasia. …”
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    The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development
  3. 1383
    “…The functional pool of canonical amino acids (cAAs) has been enriched through the emergence of non-canonical amino acids (ncAAs). …”
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    Advances in Biosynthesis of Non-Canonical Amino Acids (ncAAs) and the Methods of ncAAs Incorporation into Proteins
  4. 1384
    “…From the canonical loading coefficients, Vitality and mental health contributed the most to the quality of life (U1) canonical variable. …”
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    The association between quality of life and subjective wellbeing among older adults based on canonical correlation analysis
  5. 1385
    “…Objectives: To investigate the critical role of the canonical Wnt pathway in development of urethral fibrosis and explore DKK1, the endogenous inhibitor of Wnt pathway, as a potential target to prevent urethral fibrosis in vitro and in vivo. …”
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    DKK1 Ameliorates Myofibroblast Differentiation in Urethral Fibrosis in Vivo and in Vitro by Regulating the Canonical Wnt Pathway
  6. 1386
    “…RESULTS: PINK1 was strongly associated with a poor prognosis in ovarian cancer patients and promoted metastasis and chemoresistance in ovarian cancer cells. Although the canonical PINK1/PRKN (parkin RBR E3 ubiquitin protein ligase) pathway showed weak effects in ovarian cancer, PINK1 was identified to interact with PTEN and phosphorylate it at Serine179. …”
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    PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway
  7. 1387
    “…Interestingly, these non-canonical sRNAs are unable to move systemically and also do not induce transitive amplification. …”
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    A Non-Canonical Pathway Induced by Externally Applied Virus-Specific dsRNA in Potato Plants
  8. 1388
    “…Here, we evaluate the molecular interplay between TGF-β pathway and TAZ expression and observe that TGF-β induces TAZ expression through SMAD canonical pathway in liver cancer HepG2 cells. Therefore, TAZ cofactor is a primary target of TGF-β/SMAD-signaling, one of the pathways altered in liver cancer.…”
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    TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
  9. 1389
    “…Herein, we report that the genes encoding the canonical SSB (SisSSB) and the non-canonical SSB (SisDBP) in Saccharolobus islandicus REY15A are not essential for cell viability. …”
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    The canonical single-stranded DNA-binding protein is not an essential replication factor but an RNA chaperon in Saccharolobus islandicus
  10. 1390
    “…Phylogenetic footprinting identified CRP-S sites in the promoter regions of the Enterobacteriaceae, Pasteurellaceae and Vibrionaceae orthologs, and canonical CRP sites in orthologs of genes known to be Sxy-independent in H.influenzae. …”
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    Non-canonical CRP sites control competence regulons in Escherichia coli and many other γ-proteobacteria
  11. 1391
    “…BACKGROUND: Wnt signaling is mediated through 1) the beta-catenin dependent canonical pathway and, 2) the beta-catenin independent pathways. …”
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    Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
  12. 1392
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    Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
  13. 1393
    “…We found that Wnt7a and Wnt7b activate canonical signaling, whereas Wnt5a activates a noncanonical pathway. …”
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    Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation
  14. 1394
    “…METHODOLOGY/PRINCIPAL FINDINGS: We report here the simultaneous induction of non-canonical autophagy and apoptosis in human cancer cells upon exposure to a small molecule compound that triggers intracellular hydrogen peroxide (H(2)O(2)) production. …”
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    Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
  15. 1395
    por Huang, Sui
    Publicado 2010
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    Cell Lineage Determination in State Space: A Systems View Brings Flexibility to Dogmatic Canonical Rules
  16. 1396
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    Canonical Wnt/β-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression
  17. 1397
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    Down-Regulation of the Canonical Wnt β-Catenin Pathway in the Airway Epithelium of Healthy Smokers and Smokers with COPD
  18. 1398
    “…BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s). …”
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    Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network
  19. 1399
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    Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death
  20. 1400
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    A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels?
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