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  1. 1421
    “…CONCLUSIONS: Our studies suggest a functional non-canonical PI3Kγ activation in retinal rod photoreceptor cells.…”
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    Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells
  2. 1422
    por Mutschler, Hannes, Holliger, Philipp
    Publicado 2014
    “…Here we report such a non-canonical 3′-5′ nucleotidyl transferase activity. We engineered a variant of the hairpin ribozyme to catalyze addition of all four N>p’s (2′,3′-cyclic A-, G-, U-, and CMP) to the 5′-hydroxyl termini of RNA strands with 5′ nucleotide addition enhanced in all cases by eutectic ice phase formation at −7 °C. …”
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    Non-canonical 3′-5′ Extension of RNA with Prebiotically Plausible Ribonucleoside 2′,3′-Cyclic Phosphates
  3. 1423
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    New Insights into Flavivirus Evolution, Taxonomy and Biogeographic History, Extended by Analysis of Canonical and Alternative Coding Sequences
  4. 1424
    “…The results describe novel determinants within both the PDZ domain and outside the canonical PDZ-recognition motif that are responsible for discrimination of NPT2A between two PDZ domains. …”
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    Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1
  5. 1425
    “…We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization induced by ultraviolet light C (UVC) or the cancer therapeutic cisplatin, is followed by diversion from the canonical endocytic pathway. Instead of lysosomal degradation or plasma membrane recycling, EGFR accumulates in a subset of LBPA-rich perinuclear multivesicular bodies (MVBs) distinct from those carrying EGF-stimulated EGFR. …”
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    WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway
  6. 1426
    “…The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. …”
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    IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
  7. 1427
    “…Previous RNAi studies showed that ife-3, encoding the sole canonical eIF4E isoform of Caenorhabditis elegans, is essential for viability. …”
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    The canonical eIF4E isoform of C. elegans regulates growth, embryogenesis, and germline sex-determination
  8. 1428
    “…One classical technique for estimating the relationship between two datasets is canonical correlation analysis (CCA). However, in the context of high-dimensional data the application of CCA is extremely challenging. …”
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    Estimating multivariate similarity between neuroimaging datasets with sparse canonical correlation analysis: an application to perfusion imaging
  9. 1429
    “…Additional investigation showed that a genetically-encoded poly(A) tail is sufficient to drive decay, suggesting that degradation occurs independently of the canonical cleavage and polyadenylation reaction. Surprisingly, treatment with transcription inhibitors uncouples polyadenylation from decay, leading to runaway hyperadenylation of nuclear decay targets. …”
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    Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs
  10. 1430
    “…Within nucleosomes of actively transcribed genes, however, canonical H3 is progressively replaced by its variant H3.3. …”
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    Comparing the Assembly and Handedness Dynamics of (H3.3-H4)(2) Tetrasomes to Canonical Tetrasomes
  11. 1431
    “…We found a list of candidate clock genes and focused our attention on canonical ones: timeless, period, clock and bmal1. …”
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    Identification, Characterization, and Diel Pattern of Expression of Canonical Clock Genes in Nephrops norvegicus (Crustacea: Decapoda) Eyestalk
  12. 1432
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    Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
  13. 1433
    por Kalstrup, Tanja, Blunck, Rikard
    Publicado 2015
    “…We demonstrate that up to 25% of leak expression occurs through reinitiation in the Shaker-Kv channel when stop codons are located within the first 70 amino acids. Several non-canonical start codons were identified as translation reinitaition sites, and by removing the start codons, we were able to decrease leak expression to less than 1%. …”
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    Reinitiation at non-canonical start codons leads to leak expression when incorporating unnatural amino acids
  14. 1434
    “…Small molecules were introduced to activate (BIO) or inhibit (XAV939) the canonical Wnt pathway during stromal clone formation. …”
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    The Importance of the Canonical Wnt Signaling Pathway in the Porcine Endometrial Stromal Stem/Progenitor Cells: Implications for Regeneration
  15. 1435
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    Canonical correlations reveal co-variability between spike trains and local field potentials in area MT)
  16. 1436
    “…The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. …”
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    Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction
  17. 1437
    “…RESULTS: CR% of optic disc parameters ranged between 0.90 and 22.22% and 0.00 and 16.00% with the Canon and Zeiss OCT respectively. For macular parameters CR% ranged between 0.62 and 2.81% and 0.99 and 1.81% with the Canon and Zeiss OCT respectively. …”
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    Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000
  18. 1438
    “…In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter. …”
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    A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels
  19. 1439
    “…Moreover, these MR-dependent GRK2 and GRK5 non-canonical activities appear to involve cross-talk with the angiotensin II type-1 receptor (AT(1)R). …”
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    Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
  20. 1440
    “…EM-guided all-atom molecular dynamics simulations and solid-state NMR further reveal that the CypA-binding pattern is achieved by single-CypA molecules simultaneously interacting with two CA subunits, in different hexamers, through a previously uncharacterized non-canonical interface. These results provide new insights into how CypA stabilizes the HIV-1 capsid and is recruited to facilitate HIV-1 infection.…”
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    Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site
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