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  1. 1441
    “…These data uncover a ligand-dependent, but γ-secretase-independent, non-canonical Notch signaling involved in presynaptic protein expression in postmitotic neurons.…”
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    A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons
  2. 1442
    “…The metabolic phenotyping of these manipulations provides an integrative understanding of the functional significance of deviations from the canonical model of this hormonal pathway. Additionally, natural variation in jasmonate biosynthesis and signaling both among and within species can explain polymorphisms in resistance to insects in nature. …”
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    Beyond the Canon: Within-Plant and Population-Level Heterogeneity in Jasmonate Signaling Engaged by Plant-Insect Interactions
  3. 1443
    “…Our novel findings support a non-canonical role of class IIa HDACs in the scaffolding of transcriptional regulatory complexes, which may be relevant for therapeutic intervention for pathologies.…”
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    Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes
  4. 1444
    por Liu, Chia-Yang
    Publicado 2015
    “…This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-associated keratoconjunctivitis sicca (KCS, or dry eye). …”
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    Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
  5. 1445
    “…Understanding this integration may aid in the development of novel ALS therapies. Although the canonical Wnt/beta-catenin pathway is upregulated in ALS, riluzole, an enhancer of the canonical Wnt signaling, is classically prescribed in this disease in humans. …”
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    Opposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral Sclerosis
  6. 1446
    “…Different branches of this Wnt-signaling network, including the canonical Wnt/β-catenin and the non-canonical Wnt/PCP, Wnt/Ror2 and Wnt/Ca(2+) pathways, are assigned to distinct developmental processes and are triggered by certain ligand/receptor complexes. …”
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    Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants
  7. 1447
    “…Canonical Wnt signaling regulates the self-renewal of most if not all stem cell systems. …”
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    High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells
  8. 1448
    “…BACKGROUND: The canonical genome organization of measles virus (MV) is characterized by total size of 15 894 nucleotides (nts) and defined length of every genomic region, both coding and non-coding. …”
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    Common position of indels that cause deviations from canonical genome organization in different measles virus strains
  9. 1449
    por Seth, Chandan, Ruiz i Altaba, Ariel
    Publicado 2016
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    Correction: Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling
  10. 1450
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    Novel O-GlcNAcylation on Ser(40) of canonical H2A isoforms specific to viviparity
  11. 1451
    “…Forced expression of A20 aborted the stimulation of collagen gene expression and myofibroblast transformation induced by TGF-ß, and disrupted canonical Smad signaling and Smad-dependent transcriptional responses. …”
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    A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator
  12. 1452
    “…Both genomic release and cytoplasmic Setdb1 relocalisation during differentiation were dependent on canonical Wnt signalling. Transcriptomic assays in myoblasts unravelled a significant overlap between Setdb1 and Wnt3a regulated genetic programmes. …”
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    Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation
  13. 1453
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    Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation
  14. 1454
    “…In this study, we assessed different EF and VM parameters, via a battery of neurocognitive/psychological tests, and performed a Canonical Correlation Analysis (CCA) to explore the connection between these constructs, in a sample of middle-aged and older healthy individuals without cognitive impairment (N = 563, 50+ years of age). …”
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    The Use of Canonical Correlation Analysis to Assess the Relationship Between Executive Functioning and Verbal Memory in Older Adults
  15. 1455
    “…TCF-LEF promoter binding assay revealed that CAPE treatment reduced canonical Wnt signaling. Intraperitoneal injection of CAPE reduced the metastasis of PC-3 xenografts in tail vein injection nude mice model. …”
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    CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling
  16. 1456
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    Evidence for Altered Canonical Wnt Signaling in the Trabecular Bone of Elderly Postmenopausal Women with Fragility Femoral Fracture
  17. 1457
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    Non-canonical integration events in Pichia pastoris encountered during standard transformation analysed with genome sequencing
  18. 1458
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    Correction: Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells
  19. 1459
    “…Among them, the non-canonical 199 kDa four-domain nonribosomal peptide synthetase, AulA, is extraordinary in that it features two consecutive adenylation domains. …”
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    A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis
  20. 1460
    por Madrigal, Pedro
    Publicado 2017
    “…Here we present fCCAC, an application of functional canonical correlation analysis to assess covariance of nucleic acid sequencing datasets such as chromatin immunoprecipitation followed by deep sequencing (ChIP-seq). …”
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    fCCAC: functional canonical correlation analysis to evaluate covariance between nucleic acid sequencing datasets
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