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  1. 1481
    por Thevenon, Herve, Pfuhl, Gerit
    Publicado 2018
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    Discrepancies in the spiking threshold and frequency sensitivity of nocturnal moths explainable by biases in the canonical auditory stimulation method
  2. 1482
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    TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
  3. 1483
    “…Herein, we develop, validate, and apply a biophysical, statistical thermodynamic model of canonical target mRNA interactions with the CsrA global post-transcriptional regulator to understand the molecular features that contribute to target regulation. …”
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    A Canonical Biophysical Model of the CsrA Global Regulator Suggests Flexible Regulator-Target Interactions
  4. 1484
    por Dell'Aringa, Mark, Reinhardt, R. Lee
    Publicado 2018
    “…Given the importance of Notch signaling in the establishment of other CD4+ T-helper cell subsets, we investigated whether canonical Notch activation could differentially impact Tfh and Th2 cell fate during the induction of type-2 immunity. …”
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    Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate
  5. 1485
    “…BACKGROUND: Core canonical histones are required in the S phase of the cell cycle to pack newly synthetized DNA, therefore the expression of their genes is highly activated during DNA replication. …”
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    Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression
  6. 1486
    Publicado 2018
    “…In this paper, we present a learning-based image registration method capable of predicting 3-D rigid transformations of arbitrarily oriented 2-D image slices, with respect to a learned canonical atlas co-ordinate system. Only image slice intensity information is used to perform registration and canonical alignment, no spatial transform initialization is required. …”
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    3-D Reconstruction in Canonical Co-Ordinate Space From Arbitrarily Oriented 2-D Images
  7. 1487
    “…Together, these data indicate that canonical PRC2 function is essential for development of the mammary gland through the repression of alternate transcription programs and maintenance of chromatin states.…”
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    Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids
  8. 1488
    “…However, it is unknown if activation of the small GTPase RHOA by SMO coupling to heterotrimeric G(i) proteins, a form of non-canonical HH signaling, requires localization of SMO in the primary cilium. …”
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    Activation of the G(i) protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
  9. 1489
    “…Non-canonical NF-κB signalling plays important roles in the development and function of the immune system but it also is deregulated in a number of inflammatory diseases. …”
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    TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway
  10. 1490
    “…Collectively, these results indicate that Ret acts non-canonically to augment p75-mediated apoptosis.…”
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    Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons
  11. 1491
    por Damert, Annette
    Publicado 2018
    “…Striking similarities to the MAST2-containing human SVA_F1 suggest parallel evolution of non-canonical SVAs in chimpanzees and humans. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13100-018-0135-2) contains supplementary material, which is available to authorized users.…”
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    Phylogenomic analysis reveals splicing as a mechanism of parallel evolution of non-canonical SVAs in hominine primates
  12. 1492
    “…Together, our data reveal that loading and acetylation of H2A.Z are required to assure tight control of canonical Notch activation.…”
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    Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response
  13. 1493
    “…Taken together, these data show that transient secreted Draxin mediates proper levels of canonical Wnt signaling required to regulate the precise timing of initiation and completion of cranial neural crest EMT.…”
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    Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT
  14. 1494
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    A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis
  15. 1495
    “…The first canonical correlation pair revealed neural convergence in clusters encompassing the middle frontal gyrus and supplemental motor area, regions implicated in top-down cognitive control and affect regulation. …”
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    Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition
  16. 1496
    “…Altogether our findings suggest that PANX1 alleviates RMS malignant properties in vitro and in vivo through a process that is independent of its canonical channel function.…”
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    Pannexin 1 inhibits rhabdomyosarcoma progression through a mechanism independent of its canonical channel function
  17. 1497
    “…We refer to this approach as grand canonical alchemical perturbation (GCAP). In this work we demonstrate GCAP for two systems; Scytalone Dehydratase (SD) and Adenosine A(2A) receptor. …”
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    Ligand Binding Free Energies with Adaptive Water Networks: Two-Dimensional Grand Canonical Alchemical Perturbations
  18. 1498
    por Pucker, Boas, Brockington, Samuel F.
    Publicado 2018
    “…Analyzing 121 plant genome sequences based on their annotation revealed strong splice site conservation across species, annotation errors, and true biological divergence from canonical splice sites. The frequency of non-canonical splice sites clearly correlates with their divergence from canonical ones indicating either an accumulation of probably neutral mutations, or evolution towards canonical splice sites. …”
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    Genome-wide analyses supported by RNA-Seq reveal non-canonical splice sites in plant genomes
  19. 1499
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    Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism
  20. 1500
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    Non-canonical CTD-kinases regulate RNA polymerase II in a gene-class specific manner
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