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  1. 1501
    “…This protective effect was independent of UvrA, a component of the canonical TCR/nucleotide excision repair (NER) pathway. …”
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    Mfd protects against oxidative stress in Bacillus subtilis independently of its canonical function in DNA repair
  2. 1502
    por Shin, Chong Hyun, Choi, Doo-Sup
    Publicado 2019
    “…Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of innate immunity and cancer. …”
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    Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes
  3. 1503
    “…Our data show that WNT5A induces formation of elongated lymphatic networks through proliferation-independent WNT-signaling via RAC and JNK. Non-canonical WNT-signaling is a major mechanism of extension lymphangiogenesis, and also controls differentiation of lymphatics.…”
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    Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling
  4. 1504
    “…We observed similar conservation patterns of canonical and alternative translation start sites, which underlines the importance of alternative translation mechanisms for cellular function.…”
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    SNP and indel frequencies at transcription start sites and at canonical and alternative translation initiation sites in the human genome
  5. 1505
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    PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer
  6. 1506
    por Safonova, Yana, Pevzner, Pavel A.
    Publicado 2019
    “…We further analyze non-canonical V(DD)J recombination that results in unusually long CDR3s with tandem fused IGHD genes and thus expands the diversity of the antibody repertoires. …”
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    De novo Inference of Diversity Genes and Analysis of Non-canonical V(DD)J Recombination in Immunoglobulins
  7. 1507
    “…CONCLUSIONS: These results indicate that the canonical NF-κB signaling pathway participated in the regulation of DESC differentiation, which was through upregulating SMAD7 expression and further suppressing the canonical TGF-β-SMAD signaling pathway. …”
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    Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells
  8. 1508
    “…METHODS: Herein we report that GSK3β regulates the canonical Wnt signaling in C57Bl6 mice hearts. GSK3β is a canonical Wnt pathway inhibitor. …”
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    GSK3β inhibition and canonical Wnt signaling in mice hearts after myocardial ischemic damage
  9. 1509
    “…Telomerase, particularly its main subunit, the reverse transcriptase, TERT, prevents DNA erosion during eukaryotic chromosomal replication, but also has poorly understood non-canonical functions. Here, in the model social amoeba Dictyostelium discoideum, we show that the protein encoded by tert has telomerase-like motifs, and regulates, non-canonically, important developmental processes. …”
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    A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium
  10. 1510
    “…The present results indicated that the canonical Wnt pathway promoted diabetic myocardial fibrosis by upregulating the TGF-β1/Smad3 pathway. …”
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    Exogenous H(2)S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway
  11. 1511
    “…PgFur protein did not bind to the canonical Escherichia coli Fur box, but the wild-type phenotype of the mutant Δpgfur strain was restored partially when expression of the ecfur gene was induced from the native pgfur promoter. …”
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    Porphyromonas gingivalis PgFur Is a Member of a Novel Fur Subfamily With Non-canonical Function
  12. 1512
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    Non-canonical Expression of Cardiac Troponin-T in Neuroendocrine Ethmoid Sinus Carcinoma Following Immune Checkpoint Blockade
  13. 1513
    “…Our findings show that the modulation of canonical Wnt signalling can turn therapeutically inert mammalian cells into immortal exosome factories for cell-free therapies.…”
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    Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories
  14. 1514
    “…Through RNA sequencing and protein expression analysis, we discovered that ABI1 loss leads to activation of non-canonical WNT signaling and EMT pathways, which are rescued by re-expression of ABI1. …”
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    Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling
  15. 1515
    “…In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. …”
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    Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization
  16. 1516
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    Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase
  17. 1517
    “…These data suggest that CERES is a non-canonical translation initiation factor that modulates translation in plants.…”
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    A novel eIF4E interacting protein that forms non-canonical translation initiation complexes
  18. 1518
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    Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice
  19. 1519
    “…HCT116 cells transfected with the novel NRAS A11V and the canonical NRAS G12D, but not the KRAS mutants, display enhanced resistance to apoptosis. …”
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    Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants
  20. 1520
    “…Most metazoan polymerase II-transcribed genes carry canonical initiation with pyrimidine/purine (YR) dinucleotide, while translation machinery-associated genes carry polypyrimidine initiator (5’-TOP or TCT). …”
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    Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing
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