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  1. 1521
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    Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
  2. 1522
    “…In a sense, recent advances in the understanding of the structure–relationship of transient receptor potential canonical (TRPC) channels look promising since human TRPC channels are calcium-permeable, non-selective cation channels expressed in many tissues such as the gastrointestinal (GI) tract, kidney, heart, vasculature, and brain. …”
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    Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels
  3. 1523
    “…Drug-induced enhanced dopamine (DA) signaling in the brain is a canonical mechanism that initiates addiction processes. …”
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    Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens
  4. 1524
    “…We then identified N. brasiliensis homologs for members in each of the four canonical dauer pathways and examined their regulation during iL3 activation by either temperature or dafachronic acid. …”
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    Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation
  5. 1525
    por Nixon, Christopher C., Mavigner, Maud, Sampey, Gavin C., Brooks, Alyssa D., Spagnuolo, Rae Ann, Irlbeck, David M., Mattingly, Cameron, Ho, Phong T., Schoof, Nils, Cammon, Corinne G., Tharp, Greg K., Kanke, Matthew, Wang, Zhang, Cleary, Rachel A., Upadhyay, Amit A., De, Chandrav, Wills, Saintedym R., Falcinelli, Shane D., Galardi, Cristin, Walum, Hasse, Schramm, Nathaniel J., Deutsch, Jennifer, Lifson, Jeffrey D., Fennessey, Christine M., Keele, Brandon F., Jean, Sherrie, Maguire, Sean, Liao, Baolin, Browne, Edward P., Ferris, Robert G., Brehm, Jessica H., Favre, David, Vanderford, Thomas H., Bosinger, Steven E., Jones, Corbin D., Routy, Jean-Pierre, Archin, Nancie M., Margolis, David M., Wahl, Angela, Dunham, Richard M., Silvestri, Guido, Chahroudi, Ann, Garcia, J. Victor
    Publicado 2020
    “…Here we show that activation of the non-canonical NF-κB signaling pathway via AZD5582 results in induction of HIV- and SIV-RNA expression in the blood and tissues of ART-suppressed bone marrow/liver/thymus (BLT) humanized mice and rhesus macaques. …”
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    Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo
  6. 1526
    “…Among Gambians, highly differentiated, adaptive (CD56dimFcεR1γ-CD57+) NK cells dominate both antibody-dependent NK cell IFN-γ responses and degranulation responses, whereas among UK individuals these responses are predominantly found within canonical, highly differentiated CD56dimFcεR1γ+CD57+ NK cells. …”
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    Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses to P. falciparum
  7. 1527
    “…Transient receptor potential canonical 5 (TRPC5), is a nonselective Ca(2+) channel in neurons that interacts with many downstream molecules, participating in diverse physiological functions including temperature or mechanical sensation. …”
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    Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis
  8. 1528
    “…Here we use genetics in human cells and mice to investigate the interaction between the canonical NER and ICL repair pathways and, subsequently, how their joint inactivation phenotypically overlaps with XPF-ERCC1 deficiency. …”
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    XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways
  9. 1529
    “…Intracellular signaling responses to IL-12 were compared using flow cytometry in 2D6 cells, a cell model for canonical signaling, and B16F0 cells, where potential non-canonical signaling occurs. …”
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    Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival
  10. 1530
    “…Here, two novel non-hotspot mutants—Q661K in exon 13 and C901R in exon 19—were characterized alongside the canonical exon 9 E545K and exon 20 H1047R mutants in NIH3T3 and HCT116 cells. …”
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    Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants
  11. 1531
    “…We conclude that WNT5a is a stimulator of the EMT in OSE cells, and acts by suppressing canonical WNT signaling activity and inducing the non-canonical Ca(2+) pathway.…”
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    Non-canonical WNT5a regulates Epithelial-to-Mesenchymal Transition in the mouse ovarian surface epithelium
  12. 1532
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    Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
  13. 1533
    “…Especially the incorporation of non-canonical amino acids (ncAAs) has led to the development of numerous flexible methods for efficient and extensive expression of artificial proteins. …”
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    Emerging Methods for Efficient and Extensive Incorporation of Non-canonical Amino Acids Using Cell-Free Systems
  14. 1534
    por Najafi, S Mahmoud A
    Publicado 2020
    “…The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. …”
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    Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
  15. 1535
    “…In this study, we have combined bioorthogonal non-canonical amino acid tagging (BONCAT) and flow cytometry (FCM) analysis, and we demonstrate the applicability of the method for marine prokaryotes. …”
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    Bioorthogonal Non-canonical Amino Acid Tagging Combined With Flow Cytometry for Determination of Activity in Aquatic Microorganisms
  16. 1536
    “…The prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. …”
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    First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
  17. 1537
    “…Together, our results indicate that NFATc behaves as a non-canonical PSF for a hybrid E/M phenotype.…”
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    NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype
  18. 1538
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    AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
  19. 1539
    “…These data demonstrate a non-canonical role for the autophagy machinery in assembling antiviral signaling complexes and in establishing a TRIM5α-dependent antiviral state.…”
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    A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α
  20. 1540
    “…We confirmed further that iron activates canonical Wnt signaling in the retina using TOPFlash T-cell factor/lymphoid enhancer factor promoter assay and Axin2-LacZ reporter mouse. …”
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    Fenofibrate prevents iron induced activation of canonical Wnt/β-catenin and oxidative stress signaling in the retina
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