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  1. 1581
    “…Then, the expression of Smad2 and Smad4 proteins in the TGF-β canonical pathway was evaluated by immunohistochemistry. …”
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    Oncogenic Role of Connective Tissue Growth Factor Is Associated with Canonical TGF-β Cascade in Colorectal Cancer
  2. 1582
    “…BACKGROUND: Transient receptor potential canonical (TRPC) channels play a role in angiogenesis. …”
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    Endothelial Transient Receptor Potential Canonical Channel Regulates Angiogenesis and Promotes Recovery After Myocardial Infarction
  3. 1583
    “…Structures of the human lysosomal K(+) channel transmembrane protein 175 (TMEM175) in open and closed states revealed a novel architecture lacking the canonical K(+) selectivity filter motif present in previously known K(+) channel structures. …”
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    Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K(+) channel TMEM175
  4. 1584
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    Time Restricted Feeding to the Light Cycle Dissociates Canonical Circadian Clocks and Physiological Rhythms in Heart Rate
  5. 1585
    “…A large body of mouse and chick studies have defined a set of transcription factors and canonical Wnt signaling as the main regulators of epidermal Fgf8 expression in these organisms. …”
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    Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration
  6. 1586
    “…Together, this study elucidated the relationship between the oscillators in the absence of the canonical circadian clock, which is critical for understanding their functional significance. …”
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    Multiscale Time-resolved Analysis Reveals Remaining Behavioral Rhythms in Mice Without Canonical Circadian Clocks
  7. 1587
    “…The scales were then analysed using the canonical correlation approach (CCA). RESULTS: The results unveiled a statistically significant correlation between teamwork quality and health worker burnout indicating that teamwork quality and burnout are canonically correlated. …”
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    Teamwork quality and health workers burnout nexus: a new insight from canonical correlation analysis
  8. 1588
    “…FR900359, Sar1Ile4Ile8‐angiotensin II (SII), TRV120027 and TRV120055 were used as selective G(q/11) inhibitor and biased agonists to activate noncanonical β‐arrestin and canonical G(q/11) signaling of the AT1R, respectively. …”
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    Myogenic Vasoconstriction Requires Canonical G(q/11) Signaling of the Angiotensin II Type 1 Receptor
  9. 1589
    “…Genetic code reprogramming allows for cotranslational incorporation of non-canonical amino acids at any desired position. However, cotranslational incorporation of bulky fluorescence reporter groups is technically challenging and usually inefficient. …”
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    Ribosome selectivity and nascent chain context in modulating the incorporation of fluorescent non-canonical amino acid into proteins
  10. 1590
    “…Analysis of the protein and mRNA products of 84 cancer-related human genes identified Nectin-4 and CapG as G-quadruplex-controlled genes whose mRNAs harbor non-canonical G-quadruplex structures on their 5′UTR region. …”
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    Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation
  11. 1591
    “…These proteins cycle between an inactive Gα-GDP state and active Gα-GTP state, triggered canonically by the G-protein coupled receptor (GPCR) and by other accessory proteins receptors independent also known as AGS (Activators of G-protein Signaling). …”
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    Gαi protein subunit: A step toward understanding its non-canonical mechanisms
  12. 1592
    “…Our findings show a non-canonical profile of senescence biomarkers in the model hSOD1-G93A.…”
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    A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
  13. 1593
    “…CFA was conducted to ensure the psychometric properties of the scales, which showed that the overall model fit the data well. A canonical correlation analysis was performed, and two significant functions were revealed by the dimension reduction analysis. …”
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    Push and pull factors associated with the consumption of women’s professional basketball games: A canonical correlation analysis
  14. 1594
    “…Our findings reveal the role of the canonical transforming growth factor-β pathway in gene editing and equip ABEs with precise chemical control.…”
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    Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway
  15. 1595
    “…SIGNIFICANCE: Modified miRNAs may act as cancer biomarkers and function as allies or antagonists of their canonical counterparts in gene regulation, suggesting the concurrent consideration of canonical and modified miRNAs can boost patient stratification.…”
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    Pan-Cancer Analysis of Canonical and Modified miRNAs Enhances the Resolution of the Functional miRNAome in Cancer
  16. 1596
    “…Impaired autophagy first provokes canonical NF-κB activity, which is progressively followed by increasing levels of non-canonical NF-κB activity and cell death if the stress remains unresolved. …”
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    Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-κB signaling
  17. 1597
    “…However, most available tools are sequence-based and optimized only for peptides containing the twenty canonical amino acids. This omits a large number of peptides containing non-canonical amino acids (NCAA), or residues that undergo varied post-translational modifications such as glycosylation or phosphorylation. …”
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    Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids
  18. 1598
    “…This method is based on the generalized nonlinear canonical decomposition of a random sequence of the change of cardiogram parameters. …”
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    Computational method of the cardiovascular diseases classification based on a generalized nonlinear canonical decomposition of random sequences
  19. 1599
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    Pan-Cancer Study on Variants of Canonical miRNA Biogenesis Pathway Components: A Pooled Analysis
  20. 1600
    “…Moreover, the ephrinB2/Dsh2 interaction promotes non-canonical Wnt signaling and shows how cross-talk between two major signal transduction pathways, Eph/ephrin and Wnt, coordinate morphogenesis of the neural tube.…”
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    Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling
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