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1641por Filosto, Simone, Khan, Elaine M., Tognon, Emiliana, Becker, Cathleen, Ashfaq, Majid, Ravid, Tommer, Goldkorn, TziporaEnlace del recurso
Publicado 2011
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1642“…Here we report identification of the adaptor molecule TTRAP as a novel component of this non-canonical TGF-β pathway. We show that the protein associates with TGF-β receptors and components of the TRAF6-TAK1 signaling module, resulting in differential regulation of TGF-β activated p38 and NF-κB responses. …”
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1643
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1644
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1645“…These results suggest that maternal cues influence the fetal liver, despite the fact that we did not detect circadian rhythms of canonical clock gene expression in the fetal liver. …”
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1646por Fuller, Stephen J., McGuffin, Liam J., Marshall, Andrew K., Giraldo, Alejandro, Pikkarainen, Sampsa, Clerk, Angela, Sugden, Peter H.“…We identified an alternative ‘non-canonical’ pathway of MST3 activation (regulated primarily through dephosphorylation) which may also be applicable to other GCKIII (and GCKVI) subgroup members. …”
Publicado 2012
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1647“…The purpose of the present study was to determine whether the canonical version of the change detection task – in which the to-be-remembered information consists of simple, briefly presented features – is influenced by proactive interference. …”
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1648por Sountoulidis, Alexandros, Stavropoulos, Athanasios, Giaglis, Stavros, Apostolou, Eirini, Monteiro, Rui, Chuva de Sousa Lopes, Susana M., Chen, Huaiyong, Stripp, Barry R., Mummery, Christine, Andreakos, Evangelos, Sideras, Paschalis“…To address this, we have utilized a transgenic line harboring a BMP-responsive eGFP-reporter allele (BRE-eGFP) to construct the first detailed spatiotemporal map of canonical BMP-pathway activation during lung development, homeostasis and adult-lung injury repair. …”
Publicado 2012
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1650por Abushahba, Walid, Olabisi, Oyenike O., Jeong, Byeong-Seon, Boregowda, Rajeev K., Wen, Yu, Liu, Fang, Goydos, James S., Lasfar, Ahmed, Cohen-Solal, Karine A.“…We further show that riluzole upregulates the expression of INHBB and PLAU, two genes associated with the TGFβ signaling pathway. The non-canonical increase in Smad linker phosphorylation induced by riluzole could contribute to the modulation of the pro-oncogenic functions of Smads in late stage melanomas.…”
Publicado 2012
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1651por Chisamore-Robert, Patricia, Peeters, Samantha, Shostak, Kristina, Yankulov, Krassimir“…We also report that the destruction of the canonical B1 elements in two silencer ARS (ARS317 and ARS319) has no effect on their silencer and replicator activity. …”
Publicado 2012
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1652por Indrieri, Alessia, Conte, Ivan, Chesi, Giancarlo, Romano, Alessia, Quartararo, Jade, Tatè, Rosarita, Ghezzi, Daniele, Zeviani, Massimo, Goffrini, Paola, Ferrero, Ileana, Bovolenta, Paola, Franco, Brunella“…Now we provide the evidence that non-canonical mitochondrial-dependent apoptosis explains the phenotype of microphthalmia with linear skin lesions (MLS), an X-linked developmental disorder caused by mutations in the holo-cytochrome c-type synthase (HCCS) gene. …”
Publicado 2013
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1653por Bejugam, Pruthvi Raj, Kuppili, Raja R., Singh, Nitu, Gadewal, Nikhil, Chaganti, Lalith K., Sastry, G. Madhavi, Bose, Kakoli“…Our studies identified a novel non-canonical selective binding pocket in HtrA2 which initiates signal propagation to the distal active site through a complex allosteric mechanism. …”
Publicado 2013
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1654por Walter, Vonn, Yin, Xiaoying, Wilkerson, Matthew D., Cabanski, Christopher R., Zhao, Ni, Du, Ying, Ang, Mei Kim, Hayward, Michele C., Salazar, Ashley H., Hoadley, Katherine A., Fritchie, Karen, Sailey, Charles G., Weissler, Mark C., Shockley, William W., Zanation, Adam M., Hackman, Trevor, Thorne, Leigh B., Funkhouser, William D., Muldrew, Kenneth L., Olshan, Andrew F., Randell, Scott H., Wright, Fred A., Shores, Carol G., Hayes, D. NeilEnlace del recurso
Publicado 2013
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1656“…In this work we performed an extensive screening of human mtDNA deletions and evaluated the association between breakpoint density and presence of non-canonical DNA elements and over-represented sequence motifs. …”
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1657“…Here, we identified a mechanism that Kindlin 2 regulates myogenic regulatory factors myogenin via a canonical Wnt/β-catenin signaling. We found that knockdown of Kindlin 2 leads to the abolishment of β-catenin/TCF4-mediated transcription in C2C12 cells, followed by the impairment of myogenic differentiation. …”
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1658por Dishowitz, Michael I., Mutyaba, Patricia L., Takacs, Joel D., Barr, Andrew M., Engiles, Julie B., Ahn, Jaimo, Hankenson, Kurt D.“…Therefore, the objective of this study was to determine the importance of Notch signaling in regulating bone fracture healing by using a temporally controlled inducible transgenic mouse model (Mx1-Cre;dnMAML(f/-)) to impair RBPjκ-mediated canonical Notch signaling. The Mx1 promoter was synthetically activated resulting in temporally regulated systemic dnMAML expression just prior to creation of bilateral tibial fractures. …”
Publicado 2013
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1659por Capece, Daria, Zazzeroni, Francesca, Mancarelli, Maria Michela, Verzella, Daniela, Fischietti, Mariafausta, Di Tommaso, Ambra, Maccarone, Rita, Plebani, Sara, Di Ianni, Mauro, Gulino, Alberto, Alesse, Edoardo“…Here, we report the isolation of a novel, non-canonical Ikaros splice variant, called Ikaros 11 (Ik11). …”
Publicado 2013
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1660