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1701“…To determine the underlying anatomical basis, we quantitatively mapped canonical and noncanonical inputs to excitatory neurons in dorsal hippocampal CA1 along the proximal-distal axis in mice of both sexes using monosynaptic rabies tracing. …”
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1702por Smith, Matthew D., Harley, Margaret E., Kemp, Alain J., Wills, Jimi, Lee, Martin, Arends, Mark, von Kriegsheim, Alex, Behrends, Christian, Wilkinson, Simon“…Here, we identify cell-cycle progression gene 1 (CCPG1), an ER-resident protein with no known physiological role, as a non-canonical cargo receptor that directly binds to core autophagy proteins via an LIR motif to mammalian ATG8 proteins and, independently and via a discrete motif, to FIP200. …”
Publicado 2018
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1703por Zhou, Wenqing, Pal, Arpita S., Hsu, Alan Yi-Hui, Gurol, Theodore, Zhu, Xiaoguang, Wirbisky-Hershberger, Sara E., Freeman, Jennifer L., Kasinski, Andrea L., Deng, Qing“…Together, this direct connection between miR-223 and the canonical NF-κB pathway provides a mechanistic understanding of the multifaceted role of miR-223 and highlights the relevance of epithelial cells in dampening neutrophil activation.…”
Publicado 2018
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1704por Whitson, Ramon J., Lee, Alex, Urman, Nicole M., Mirza, Amar, Yao, Catherine Y., Brown, Alexander S., Li, Jiang R., Shankar, Gautam, Fry, Micah A., Atwood, Scott X., Hollmig, S. Tyler, Aasi, Sumaira Z., Sarin, Kavita Y., Epstein, Ervin H., Tang, Jean Y., Oro, Anthony E.“…Hedgehog pathway-dependent cancers can escape smoothened (SMO) inhibition through canonical pathway mutations, however, 50% of resistant BCCs lack additional variants in hedgehog genes. …”
Publicado 2018
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1705“…CCA results showed overall FF was positively correlated with overall MMSE in both men (canonical coefficient = 0.37, P < 0.0001) and women (first canonical coefficient = 0.42, P < 0.0001; second canonical coefficient = 0.17, P = 0.004). …”
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1706por Hao, Xiaoke, Li, Chanxiu, Yan, Jingwen, Yao, Xiaohui, Risacher, Shannon L, Saykin, Andrew J, Shen, Li, Zhang, Daoqiang“…In this article, we propose a novel temporally constrained group sparse canonical correlation analysis (TGSCCA) framework to identify genetic associations with longitudinal phenotypic markers. …”
Publicado 2017
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1707“…The medical and psychosocial factors were also correlated. The canonical correlation analysis indicated a correlation between QoL and psychosocial factors (1st canonical correlation = 0.696, P < 0.001; 2nd canonical correlation = 0.421, P = 0.191), but not medical factors (1st canonical correlation = 0.478, P = 0.475; 2nd canonical correlation = 0.419, P = 0.751). …”
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1708Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis“…The prevailing view of canonical mRNA decay is that it is mediated by deadenylation and decapping followed by exonucleolysis from the 3′ and 5′ ends. …”
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1709por Shiloh, Ruth, Gilad, Yuval, Ber, Yaara, Eisenstein, Miriam, Aweida, Dina, Bialik, Shani, Cohen, Shenhav, Kimchi, AdiEnlace del recurso
Publicado 2018
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1710por Morales-Menchén, Ana, Navarro-García, Federico, Guirao-Abad, José P., Román, Elvira, Prieto, Daniel, Coman, Ioana V., Pla, Jesús, Alonso-Monge, RebecaEnlace del recurso
Publicado 2018
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1711por D’Angelo, Chiara, Reale, Marcella, Costantini, Erica, Di Nicola, Marta, Porfilio, Italo, de Andrés, Clara, Fernández-Paredes, Lidia, Sánchez-Ramón, Silvia, Pasquali, Livia“…The aim of the study was to define, in clinically stable patients with RR-MS, the serum concentration of several cytokines, canonical or not, and their modulation by IFN-β therapy. …”
Publicado 2018
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1713por Dairaghi, Leigh, Flannery, Ellen, Giacobini, Paolo, Saglam, Aybike, Saadi, Hassan, Constantin, Stephanie, Casoni, Filippo, Howell, Brian W., Wray, Susan“…This study was initiated to delineate the non-canonical Reelin signaling pathways used by GnRH neurons. …”
Publicado 2018
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1715por Yang, Li, Chen, Jing, Han, Xiaoyan, Zhang, Enfan, Huang, Xi, Guo, Xing, Chen, Qingxiao, Wu, Wenjun, Zheng, Gaofeng, He, Donghua, Zhao, Yi, Yang, Yang, He, Jingsong, Cai, Zhen“…Therefore, Pirh2 suppressed the canonical NF-κB signaling pathway by inhibiting the phosphorylation and subsequent degradation of IKBa to overcome acquired bortezomib resistance in MM cells.…”
Publicado 2018
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1716por Dervishi, Ina, Gozutok, Oge, Murnan, Kevin, Gautam, Mukesh, Heller, Daniel, Bigio, Eileen, Ozdinler, P. Hande“…Protein products of these genes and their interactions helped determine the protein landscape of ALS, and revealed upstream modulators, key canonical pathways, interactome domains and novel therapeutic targets. …”
Publicado 2018
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1717“…The correlation between chemical constituents and active ingredients (primarily anthocyanins and rutins) of 13 new types of Chinese mulberries was assessed using partial‐least‐squares, principle‐component and canonical‐correlation analyses. RESULTS: Vitamin C and titratable acid in the mulberry fruits were critical components that affected the active ingredients, especially anthocyanins and rutins. …”
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1718por Zhang, Yifei, Rong, Hua, Zhang, Fang-Xiong, Wu, Kun, Mu, Libing, Meng, Junchen, Xiao, Bailong, Zamponi, Gerald W., Shi, Yan“…We report here that canonical NLRP3 activation leads to Ca(2+) flux and increased calpain activity. …”
Publicado 2018
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1719“…RESULTS: Using published canonical Hi-C data and single-cell genome structures, we assess the spatial proximity of a genome-wide array of potential TF-TF co-localizations in human and mouse cell lines. …”
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1720por Zhang, Kuo, Zhang, Yuying, Gu, Lijie, Lan, Miaomiao, Liu, Chuncheng, Wang, Meng, Su, Yang, Ge, Mengxu, Wang, Tongtong, Yu, Yingying, Liu, Chang, Li, Lei, Li, Qiuyan, Zhao, Yaofeng, Yu, Zhengquan, Wang, Fudi, Li, Ning, Meng, Qingyong“…Islr interacts with Dishevelled-2 (Dvl2) to activate canonical Wnt signaling, consequently regulating the myogenic factor myogenin (MyoG). …”
Publicado 2018
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