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  1. 1741
    “…In conclusion, using an integrative literature- and data-mining approach, we have identified and described a canonical pathway underlying progression of NASH. Other parameters (e.g., polymorphisms) can be added to this pathway that also contribute to the progression of the disease to cancer. …”
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    Lipid Related Genes Altered in NASH Connect Inflammation in Liver Pathogenesis Progression to HCC: A Canonical Pathway
  2. 1742
    “…Wnt signaling through both canonical and noncanonical pathways plays a core role in development. …”
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    HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2
  3. 1743
    “…We also found that NL- and iDOT1L-induced canonical WNT activation facilitates the initial development kinetics of iPSCs. …”
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    NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities
  4. 1744
    “…In the current study, trehalose simultaneously protects substantia nigra dopaminergic cells by activating both non-canonical p62/SQSTM1-Keap1-Nrf2 and autophagy pathways.…”
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    Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways
  5. 1745
    “…The study shows that genetic or chemical activation of canonical Wnt signaling enhances radiosensitivity of HSCs while inhibition of Wnt signaling decreases it. …”
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    High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage
  6. 1746
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    A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer
  7. 1747
    “…BioOrthogonal Non-Canonical Amino acid Tagging (BONCAT) is a powerful tool for tracking protein synthesis on the level of single cells within communities and whole organisms. …”
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    Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis
  8. 1748
    “…In exudative AMD, the increase of the canonical WNT/β-catenin pathway is enhanced by the dysregulation of circadian rhythms. …”
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    Circadian Rhythms in Exudative Age-Related Macular Degeneration: The Key Role of the Canonical WNT/β-Catenin Pathway
  9. 1749
    “…TENT5C is a non-canonical cytoplasmic poly(A) polymerase highly expressed by activated B cells to suppress their proliferation. …”
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    Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
  10. 1750
    “…Here, we apply bioorthogonal non-canonical amino acid tagging (BONCAT) to visualize and quantify bacterial translational activity in expectorated sputum. …”
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    Bioorthogonal non-canonical amino acid tagging reveals translationally active subpopulations of the cystic fibrosis lung microbiota
  11. 1751
    “…We also show that the ACC-related KIF21B variant independently perturbs axonal growth and ipsilateral axon branching through two distinct mechanisms, both leading to deregulation of canonical kinesin motor activity. The duplication introduces a premature termination codon leading to nonsense-mediated mRNA decay. …”
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    Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity
  12. 1752
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    ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes
  13. 1753
    “…Through a forward-genetics CRISPR-Cas9 screen, we identified an antagonistic relationship between LSD1 and the non-canonical BAF (ncBAF) chromatin remodeling complex. …”
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    Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis
  14. 1754
    “…In addition, it owns much better discriminative canonical weight patterns of great interest than competitors. …”
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    Identifying diagnosis-specific genotype–phenotype associations via joint multitask sparse canonical correlation analysis and classification
  15. 1755
    por Yeo, Syn Kok, Guan, Jun-Lin
    Publicado 2020
    “…We showed that although FIP200's autophagy function was required for progression of PyMT-driven mammary tumors, FIP200's canonical-autophagy-independent function was responsible for increased T-cell infiltration, IFN-signaling and ICB efficacy. …”
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    Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function
  16. 1756
    “…Mechanistically, EHF could directly upregulate transforming growth factor β1 (TGF‐β1) expression at the transcription level, thereby activating canonical TGF‐β signaling. Our findings provide novel insights into the mechanisms of EHF in tumorigenesis, invasion, and metastasis of CRC, which may help to provide new therapeutic targets for CRC intervention.…”
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    EHF promotes colorectal carcinoma progression by activating TGF‐β1 transcription and canonical TGF‐β signaling
  17. 1757
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    Generalized Linear Models outperform commonly used canonical analysis in estimating spatial structure of presence/absence data
  18. 1758
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    Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
  19. 1759
    “…In addition, numerous aaRSs (mostly in vertebrates) have also been discovered to possess a range of non-canonical functions. Very few studies have been conducted to elucidate or characterize non-canonical functions of plant aaRSs. …”
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    Plant-Specific Domains and Fragmented Sequences Imply Non-Canonical Functions in Plant Aminoacyl-tRNA Synthetases
  20. 1760
    “…The levels of effector proteins of the canonical and non-canonical branches of the NF-κB pathway, and the phosphorylation of JNK, Akt, ERK1/2, STAT1 and STAT3 involved in diverse signaling cascades, were measured by Western blotting. …”
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    Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor
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