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  1. 1761
    “…We have previously reported that induction of non-canonical nuclear factor κB (NF-κB) signaling through a class of small-molecule antagonists known as Smac mimetics can reverse HIV-1 latency. …”
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    Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo
  2. 1762
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    KLF5 regulates chicken skeletal muscle atrophy via the canonical Wnt/β-catenin signaling pathway
  3. 1763
    “…Using tumor necrosis factor (TNF)α as a model substrate, we identify a non-canonical shedding activity of SPPL2a, an intramembrane cleaving aspartyl protease of the GxGD type. …”
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    Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix
  4. 1764
    “…Yet, whether such transcripts are truly non-coding or rather the source of non-canonical protein translation is unknown. Here, we used functional genomic screens to establish the cellular bioactivity of non-canonical proteins located in putative non-coding RNAs or untranslated regions of protein-coding genes. …”
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    TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL
  5. 1765
    “…It has been known adipocytes increase p53 expression and activity in obesity, however, only canonical p53 functions (i.e. senescence and apoptosis) are attributed to inflammation-associated metabolic phenotypes. …”
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    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming
  6. 1766
    “…In contrast, we find that two internal sites remain inaccessible, suggesting that such non-canonical nucleosome species generated during transcription are rapidly and efficiently converted to canonical nucleosome structure and thus not widely present in native chromatin.…”
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    Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes
  7. 1767
    “…In summary, we demonstrate the suppressive role of MITF in lung cancer progression, which is opposite to the canonical oncogenic function of MITF in melanoma.…”
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    MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role
  8. 1768
    “…To address this problem, we present a method that enables the systematic enhancement of the activity of a single-domain antibody through the post-translational installation of non-canonical side chains by chemical mutagenesis. We illustrate this approach by performing a structure-activity relationship study beyond the 20 naturally occurring amino acids on a single-domain antibody designed in silico to inhibit the aggregation of the amyloid-β peptide, a process closely linked to Alzheimer's disease. …”
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    Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis
  9. 1769
    “…Our results suggest that in addition to the regular canonical SMAD signaling BMP2 induces non-canonical inflammatory pathway in HRECs via activation of p38/NFκB pathway that causes the upregulation of VEGF and the disruption of HRECs. …”
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    Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells
  10. 1770
    por Lue, Neal F.
    Publicado 2021
    “…However, emerging evidence suggests that even in fungi with the canonical 6-bp telomere repeat unit, there are significant remodeling of the telomere assembly. …”
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    Duplex Telomere-Binding Proteins in Fungi With Canonical Telomere Repeats: New Lessons in the Rapid Evolution of Telomere Proteins
  11. 1771
    “…Canonical transforming growth factor-beta (TGF-β) signaling exerts neuroprotection and influences memory formation and synaptic plasticity. …”
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    Canonical TGF-β signaling regulates the relationship between prenatal maternal depression and amygdala development in early life
  12. 1772
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    MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway
  13. 1773
    por Owa, Mikito, Dynlacht, Brian
    Publicado 2021
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    A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
  14. 1774
    por Zhou, Zengzi, Xia, Meng, Lv, Jianlin
    Publicado 2021
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    Transient Receptor Potential Canonical 4 Channel in Interstitial Cells of Cajal as a Target for Control of Gastrointestinal Motility
  15. 1775
    “…Uridine insertion/deletion (U-indel) editing of mitochondrial mRNA, unique to the protistan class Kinetoplastea, generates canonical as well as potentially non-productive editing events. …”
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    Complete minicircle genome of Leptomonas pyrrhocoris reveals sources of its non-canonical mitochondrial RNA editing events
  16. 1776
    “…Using whole genome bisulfite sequencing, we identified a focal, canonical DNA hypomethylation phenotype in the epidermal cells of Dnmt3a-deficient mice. …”
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    Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype
  17. 1777
    “…Taken together, our study indicated that FABP5 enhances malignancies of LGGs through canonical activation of NF‐κB signalling, which could be used as individualized prognostic biomarker and potential therapeutic target of LGGs.…”
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    FABP5 enhances malignancies of lower‐grade gliomas via canonical activation of NF‐κB signaling
  18. 1778
    “…The eukaryotic signal recognition particle (SRP) contains an Alu domain, which docks into the factor binding site of translating ribosomes and confers translation retardation. The canonical Alu domain consists of the SRP9/14 protein heterodimer and a tRNA-like folded Alu RNA that adopts a strictly ‘closed’ conformation involving a loop-loop pseudoknot. …”
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    Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation
  19. 1779
    “…Twenty-eight adults verified solutions to simple addition problems that were shown in the form of canonical or non-canonical finger-number montring patterns while measuring Event Related Potentials (ERPs). …”
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    Electrophysiological evidence for internalized representations of canonical finger-number gestures and their facilitating effects on adults’ math verification performance
  20. 1780
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    A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing
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