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  1. 1801
    “…Klotho also transcriptionally downregulated the H3K27 demethylase Jmjd3, leading to increased H3K27 methylation and decreased expression of genes in the canonical Wnt pathway, which was associated with a delay in muscle differentiation. …”
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    The anti‐aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway
  2. 1802
    “…Our findings uncover the additional function of DHQS in AMR and provide an insight into a non-canonical resistance mechanism by which protein hijacks antibiotic to reduce the interaction between antibiotic and its target with normal protein function retained.…”
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    Dehydroquinate Synthase Directly Binds to Streptomycin and Regulates Susceptibility of Mycobacterium bovis to Streptomycin in a Non-canonical Mode
  3. 1803
    “…We conclude that the canonical BMP-signaling pathway might be responsible for regulating the expression of AQP4 and of DAP complex proteins that govern the subcellular compartmentation of this aquaporin.…”
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    Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes
  4. 1804
    “…Here, we present a unified protocol for the extraction, culture, and basic characterization of rat neural stem cells (NSCs) from all three canonical neurogenic niches in the brain and spinal cord. …”
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    Isolation and comparison of neural stem cells from the adult rat brain and spinal cord canonical neurogenic niches
  5. 1805
    “…Notably, multivariate Ab profiles directed against canonical or non-canonical antigens are equally discriminative of survival in severe COVID-19. …”
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    Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19
  6. 1806
    por Kelly, Barry
    Publicado 2022
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    A Golden age and the Floating Man: Ireland, Avicenna and the Canon of Medicine: Delivered 27th November 2018
  7. 1807
    “…The fine resolution of the canonical clusters defined here revealed unique signatures within these pockets, including distinct structural complementarities between CDR-H1 and CDR-H2 canonical clusters, which could not be perceived with the previous coarser clusters. …”
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    Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs
  8. 1808
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    Light shed on a non-canonical TCA cycle: cell state regulation beyond mitochondrial energy production
  9. 1809
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    Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12
  10. 1810
    “…The binding of cetuximab to the extracellular domain of EGFR suppresses ligand-induced events; therefore, we focus on ligand-independent non-canonical EGFR endocytosis for the delivery of ADCs into cells. …”
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    Synchronous intracellular delivery of EGFR-targeted antibody–drug conjugates by p38-mediated non-canonical endocytosis
  11. 1811
    “…Here, we found that transforming growth factor β (TGFβ) priming enables TNF to effectively induce osteoclastogenesis, independently of the canonical RANKL pathway. Lack of TGFβ signaling in macrophages suppresses inflammatory, but not basal, osteoclastogenesis and bone resorption in vivo. …”
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    TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis
  12. 1812
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    Activation of the canonical ER stress IRE1–XBP1 pathway by insulin regulates glucose and lipid metabolism
  13. 1813
    “…There is substantial interest in mining neoantigens for cancer applications. Non-canonical proteins resulting from frameshift mutations have been identified as neoantigens in cancer. …”
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    A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response
  14. 1814
    “…In addition to the classic 7-methylguanosine 5′ cap in eukaryotic mRNA, several non-canonical caps have recently been identified, including NAD-linked, FAD-linked, and UDP-glucose-linked RNAs. …”
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    Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping
  15. 1815
    “…The aim of this study was to examine the relationship between perception of 3-dimensional facial attractiveness and golden ratio, neoclassical canons, ‘ideal’ ratios and ‘ideal’ angles in Hong Kong Chinese. …”
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    Does 3-dimensional facial attractiveness relate to golden ratio, neoclassical canons, ‘ideal’ ratios and ‘ideal’ angles?
  16. 1816
    “…Here, we show that the Vibrio cholerae toxin MakA is a novel cholesterol-binding PFT that induces non-canonical autophagy in a pH-dependent manner. MakA specifically binds to cholesterol on the membrane at pH < 7. …”
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    V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy
  17. 1817
    “…Consequently, the canonical miR-16 activity, involved in the RNA decay of oncogenes, such as cyclin D3, is impaired. …”
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    Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16
  18. 1818
    “…Neurodevelopmental research has traditionally focused on development of individual structures, yet multiple lines of evidence indicate parallel development of large-scale systems, including canonical neural networks (i.e., default mode, frontoparietal). …”
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    Task-based co-activation patterns reliably predict resting state canonical network engagement during development
  19. 1819
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    A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior
  20. 1820
    “…Eleven non-canonical splice site variants were selected based on four splice prediction tools. …”
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    Minigene-Based Splice Assays Reveal the Effect of Non-Canonical Splice Site Variants in USH2A
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