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  1. 1821
    “…We find that most mutations that improve fitness in galactose lie outside of the canonical GAL pathway. Reconstruction of specific evolved alleles in candidate target of selection, SEC23 and IRA1, showed a significant increase in fitness in galactose compared to glucose. …”
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    Long-Term Adaptation to Galactose as a Sole Carbon Source Selects for Mutations Outside the Canonical GAL Pathway
  2. 1822
    “…Transient receptor potential canonical (TRPC) channels are non-selective calcium-permeable cation channels. …”
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    Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1
  3. 1823
    “…Phylogenetic analysis revealed two independent clades in canonical sPLA(2) genes referred to as α and β clades, whereas PLA(2)-like genes clustered independently as a third clade. …”
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    Comparative phylogenomic and structural analysis of canonical secretory PLA2 and novel PLA2-like family in plants
  4. 1824
    “…While the contribution of the canonical Wnt/b-catenin signaling in both normal and CSCs had been well established, the function of non-canonical Wnt signaling cascades in stem cells is unclear. …”
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    Non-canonical Wnt/Ca2+ signaling is essential to promote self-renewal and proliferation in colon cancer stem cells
  5. 1825
    por Zhu, Bokai, Liu, Silvia
    Publicado 2023
    “…To distinguish among these possibilities, we performed a post-hoc analysis of two high temporal resolution transcriptome dataset in animals and cells lacking the canonical circadian clock. In both the liver of BMAL1 knockout mice and Drosophila S2 cells, we observed robust and prevalent ~12-hour rhythms of gene expression enriched in fundamental processes of mRNA and protein metabolism that show large convergence with those identified in wild-type mice liver. …”
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    Preservation of ~12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock
  6. 1826
    “…In this study, we showed that the AML-specific autocrine loop comprised of T-cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9 (Gal-9), drives the canonical Wnt pathway to stimulate self-renewal and propagation of LSCs, independent of Wnt ligands. …”
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    TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia
  7. 1827
    por Shan, Wenshan, Li, Shuang, Yin, Zongsheng
    Publicado 2023
    “…We performed differential analysis by R (DEseq2) or GEO2R and found that the AIM2/NLRC4/NLRP3 inflammasome-related genes, GSDMD, IL1B, and IL18, were highly expressed in SCI. Based on the canonical NLRP3 inflammasome-mediated pyroptosis-related genes (NLRP3/PRGs), we constructed transcription factors (TFs)–NLRP3/PRGs, miRNAs- Nlrp3/PRGs and lncRNAs/circRNAs/mRNAs–miRNA- Nlrp3/PRGs (ceRNA) networks. …”
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    Identification of canonical pyroptosis-related genes, associated regulation axis, and related traditional Chinese medicine in spinal cord injury
  8. 1828
    “…Therefore, to propose previously unknown mechanisms for this disease, we have investigated the functional impact of translation of non-canonical open reading frames (ORFs) across medulloblastoma model systems. …”
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    MDB-32. TRANSLATION OF NON-CANONICAL OPEN READING FRAMES AS A CANCER CELL SURVIVAL MECHANISM IN CHILDHOOD MEDULLOBLASTOMA
  9. 1829
    por Zhu, Bokai, Liu, Silvia
    Publicado 2023
    “…Methods: To distinguish among these possibilities, we performed a post hoc analysis of two high temporal resolution transcriptome dataset in animals and cells lacking the canonical circadian clock. Results: In both the liver of BMAL1 knockout mice and Drosophila S2 cells, we observed robust and prevalent ∼12-h rhythms of gene expression enriched in fundamental processes of mRNA and protein metabolism that show large convergence with those identified in wild-type mice liver. …”
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    Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock
  10. 1830
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    Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells
  11. 1831
    “…Therefore, liposomal CRE-SD can inhibit osteoclastogenesis via the canonical NF-κB signaling pathway, suggesting its pharmacological potential for treating bone diseases with excessive osteoclastogenesis.…”
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    Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway
  12. 1832
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    Identification of a non-canonical ciliate nuclear genetic code where UAA and UAG code for different amino acids
  13. 1833
    “…We examine the reaction mechanism using the new grand canonical potential kinetics (GCP-K) or grand canonical quantum mechanics (GC-QM) computational methodology, which obtains reaction rates at constant applied potential to compare directly with experimental results (rather than at constant electrons as in standard QM). …”
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    CO(2) Reduction to Methane and Ethylene on a Single-Atom Catalyst: A Grand Canonical Quantum Mechanics Study
  14. 1834
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    Non-canonical C-terminal variant of MeCP2 R344W exhibits enhanced degradation rate
  15. 1835
    “…In this paper, we combine a canonical variable analysis (CVA) and adaptive kernel density estimation (AKDE) for the early fault detection of nonlinear dynamic hydraulic systems. …”
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    Incipient Fault Detection in a Hydraulic System Using Canonical Variable Analysis Combined with Adaptive Kernel Density Estimation
  16. 1836
    “…CONCLUSIONS: Collectively, these findings argue for a non-canonical role for the ATR kinase in STAT3 activation in MM cells, and suggest that STAT3 inactivation contributes to the lethal actions of ATR inhibitors in MM. …”
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    Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
  17. 1837
    “…Here, using rsfMRI data from over 100k individuals across private and public datasets, we identify replicable multi‐spatial‐scale canonical intrinsic connectivity network (ICN) templates via the use of multi‐model‐order independent component analysis (ICA). …”
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    Identifying canonical and replicable multi‐scale intrinsic connectivity networks in 100k+ resting‐state fMRI datasets
  18. 1838
    por Sharma, Divya, Xu, Wei
    Publicado 2023
    “…In this article, we propose a framework combining genetic data into pathway structure and using an ensemble of convolutional neural networks (CNNs) along with a Canonical Correlation Regularizer layer for comprehensive prediction of disease risk. …”
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    ReGeNNe: genetic pathway-based deep neural network using canonical correlation regularizer for disease prediction
  19. 1839
    “…Functional activation of canonical Wnt or TGF-β/BMP pathways during melanocyte regeneration promoted melanocyte regeneration but potently suppressed the invasiveness, migration, and proliferation of human melanoma cells in vitro and in vivo. …”
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    Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells
  20. 1840
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    MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient Mice
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