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  1. 1921
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    Correction: Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes
  2. 1922
    “…Thyrocytes of taar1(-/-) mice are characterized by non-canonical TSH receptor localization in intracellular compartments, which is accompanied by altered thyroglobulin turnover due to a disbalanced proteolytic network. …”
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    Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression
  3. 1923
    “…We found similar features in published datasets using two other viruses: Ebola virus (EBOV; -ssRNA genome) and a herpesvirus (dsDNA genome), both produced with the Illumina Nextera protocol. These canonical features suggest that artificial chimeras are generated by intra-molecular template switching of the DNA polymerase during the PCR step of the Nextera protocol. …”
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    A Survey of Virus Recombination Uncovers Canonical Features of Artificial Chimeras Generated During Deep Sequencing Library Preparation
  4. 1924
    “…The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the chemical space of various antimicrobials. …”
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    Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics
  5. 1925
    “…Here, we show that the canonical PI3Kγ pathway is upregulated in both human chagasic hearts and hearts of acutely infected mice. …”
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    Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis
  6. 1926
    “…In the present study, the role of canonical NF-κB signaling in myeloid cells in metastatic breast cancer was addressed by myeloid-specific deletion of Ikkβ in the MMTV polyoma middle T (PyMT) mouse model. …”
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    Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model
  7. 1927
    “…We performed all-atom canonical molecular dynamics simulations for a 20-residue PGA, over a total of 19 μs, in order to investigate its helix-unfolding processes in atomic resolution. …”
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    Unfolding of α-helical 20-residue poly-glutamic acid analyzed by multiple runs of canonical molecular dynamics simulations
  8. 1928
    “…Our results suggest that the halophilic character is an ancient trait in the evolution of this protein family and that proteins from Methanosarcinales have adapted to highly saline environments by a non-canonical strategy, different from that currently proposed for Halobacteria. …”
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    ADP-Dependent Kinases From the Archaeal Order Methanosarcinales Adapt to Salt by a Non-canonical Evolutionarily Conserved Strategy
  9. 1929
    “…Residue-specific incorporation of the non-canonical amino acid is analyzed by mass spectrometry. …”
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    Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence
  10. 1930
    “…In this study, animal experimentation verified that the canonical Wnt/β-catenin signaling pathway was activated under a reduced activity of p-β-catenin (Ser33/37/Thr41) and an increased accumulation of β-catenin in the lungs and kidneys of pigs infected with a highly virulent strain of H. parasuis. …”
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    Haemophilus parasuis Infection Disrupts Adherens Junctions and Initializes EMT Dependent on Canonical Wnt/β-Catenin Signaling Pathway
  11. 1931
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    The “Canone Inverso”: when tobacco was not so bad. A look back at the primordial debate on the tobacco effects in the occupational medicine
  12. 1932
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    Canonical Wnt/β-catenin signaling activation in soft-tissue sarcomas: A comparative study of synovial sarcoma and leiomyosarcoma
  13. 1933
    “…Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. …”
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    Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration
  14. 1934
    “…Our work provides a toolbox for successful generation of enzyme variants with non-canonical catalytic proline analogues.…”
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    Substituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system
  15. 1935
    “…Further, we interrogated the proteome of three different wild-type P. aeruginosa strains, their eftM mutants, and these mutants complemented with eftM and conclude that trimethylation of EF-Tu by EftM does not impact EF-Tu’s canonical function in translation. In addition to furthering our knowledge of this Pseudomonas virulence factor, this study provides an intriguing example of a protein with multiple layers of thermoregulation.…”
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    Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation
  16. 1936
    “…BACKGROUND: Non-canonical Wnt pathways play important roles in liver fibrosis. …”
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    Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways
  17. 1937
    “…The aim of the present study is to characterize the productive capability of Utrerana and to compare the relationships among parameters determining the internal and external quality of the egg, through canonical correlation analysis. We used a flock of 68 Utrerana hens with animals of each of its four varieties (white, black, Franciscan and partridge), and a group of 17 Leghorn hens as a control group. …”
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    Non-Parametrical Canonical Analysis of Quality-Related Characteristics of Eggs of Different Varieties of Native Hens Compared to Laying Lineage
  18. 1938
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    Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells
  19. 1939
    “…The results showed that at low concentration (0.05% Roundup) and short exposure (48h), both cell lines suffered deregulation of 11 canonical pathways, the most important being cell cycle and DNA damage repair pathways. …”
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    Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines
  20. 1940
    por Chen, Hailin, Zhang, Zuping, Feng, Dayi
    Publicado 2019
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    Prediction and interpretation of miRNA-disease associations based on miRNA target genes using canonical correlation analysis
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