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  1. 19381
    “…CONCLUSIONS: We provide mechanistic insight into GATA6 tumour-suppressive function, its role as a regulator of canonical epithelial differentiation, and propose that loss of GATA6 expression is both prognostic and predictive of response to adjuvant therapy.…”
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    GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
  2. 19382
    “…In addition, chromatin immunoprecipitation (ChIP) assays showed that Osx associated with the ZBTB16 promoter region containing the GC‐rich canonical Sp1 sequence, which is the specific Osx binding site. …”
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    ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells
  3. 19383
    “…Two VPS13B mutations abolished the canonical splice sites resulting in low RNA expression in transformed lymphoblasts of the proband. …”
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    Exome sequencing identifies pathogenic variants of VPS13B in a patient with familial 16p11.2 duplication
  4. 19384
    “…CONCLUSIONS: These experiments altogether highlight the consistent absence of canonical L1 retrotransposition in GBM tumours and cultured cell lines, as well as atypical L1-associated sequence rearrangements following DNA damage in vivo. …”
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    Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme
  5. 19385
    “…Three morphological categories according to nuclear size (small <10.90 μm(2), intermediate 10.91–13.07 μm(2), and large >13.07 μm(2)) and four categories were defined on 400 canonical cells (100 × 4) from 10 men according to sperm nuclear shape (oval, pyriform, round, and elongated). …”
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    Comparison of different statistical approaches to evaluate morphometric sperm subpopulations in men
  6. 19386
    “…Conclusively, ALK1,2,3,6-signalling was essential for MSC-chondrogenesis and its prochondrogenic rather than prohypertrophic role may explain why inhibition of canonical BMP-signalling could not uncouple cartilage matrix production from hypertrophy as this was achieved with pulsed PTHrP-application.…”
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    Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation
  7. 19387
    “…Thus, epithelial cancer cells rely on the canonical PI3K-AKT signaling pathway for survival, while mesenchymal cancer cells deploy the PI3K-independent mTORC2-AKT axis in response to strong death stimuli.…”
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    Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis
  8. 19388
    “…The isoform itself lacks canonical enzymatic activity as it misses the non-heme iron but it still retains ATP-binding affinity. …”
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    Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase
  9. 19389
    “…Kc167 piRNAs are produced by a canonical, primary piRNA biogenesis pathway, from phased processing of precursor transcripts by the Zuc endonuclease, Armi helicase, and dGasz mitochondrial scaffold protein. …”
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    Kc167, a widely used Drosophila cell line, contains an active primary piRNA pathway
  10. 19390
    “…METHODS: Three molecular typing methods, namely canonical single nucleotide polymorphisms (canSNP), multiple-locus variable-number tandem repeat analysis (MLVA), and single nucleotide repeat (SNR) analysis, were used to investigate the possible source of transmission and identify the genetic relationship among the strains isolated from human cases and diseased animals during the outbreak. …”
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    Genetic source tracking of an anthrax outbreak in Shaanxi province, China
  11. 19391
    “…Consistently, the expression of β-catenin, the major mediator of canonical Wnt pathway that is capable of inducing endothelial differentiation and angiogenesis, was upregulated by IL-1β through miR-433. …”
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    IL-1β-stimulated β-catenin up-regulation promotes angiogenesis in human lung-derived mesenchymal stromal cells through a NF-κB-dependent microRNA-433 induction
  12. 19392
    “…The measurements are used to distinguish among the four groups of Riccardia and also between the two groups of Riccardia amazonica collected in different locations, Africa and South America. Canonical discriminant analysis results show that those measurements are able to discriminate among the four groups. …”
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    Quantitative morphological analysis of 2D images of complex-shaped branching biological growth forms: the example of branching thalli of liverworts
  13. 19393
    “…A downstream 5′ splice site is linked to an upstream 3′ splice site to form a circular transcript instead of a canonical linear transcript. Recent advances in next-generation sequencing (NGS) have brought circRNAs back into the focus of many scientists. …”
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    FUCHS—towards full circular RNA characterization using RNAseq
  14. 19394
    “…Emerging evidence indicates that the dysregulation of protein ubiquitination plays a crucial role in aging‐associated diseases. Smad‐dependent canonical BMP signaling pathway is indispensable for osteoblastic bone formation, which could be disrupted by the ubiquitination and subsequent proteasomal degradation of Smad1/5, the key molecules for BMP signaling transduction. …”
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    Increased PLEKHO1 within osteoblasts suppresses Smad‐dependent BMP signaling to inhibit bone formation during aging
  15. 19395
    “…Recent studies indicate that the transient receptor potential canonical 6 (TRPC6) channel is highly expressed in several types of cancer cells. …”
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    Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion
  16. 19396
    “…Ingenuity Pathway Analysis was employed to investigate the canonical pathways and functional networks involved in the infection. …”
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    Comparative Proteomics Analysis of Human Macrophages Infected with Virulent Mycobacterium bovis
  17. 19397
    “…Particular emphasis has been put towards characterizing the algal homologs of the canonical rate-limiting enzymes, diacylglycerol acyltransferase (DGAT) and phospholipid:diacylglycerol acyltransferase (PDAT). …”
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    Analysis of triglyceride synthesis unveils a green algal soluble diacylglycerol acyltransferase and provides clues to potential enzymatic components of the chloroplast pathway
  18. 19398
    “…A conjunction analysis revealed that skull taps elicit overlapping activation with auditory tone bursts in the canonical vestibular cortical regions. Further, our postural control assessments revealed that greater amplitude of brain activation in response to vestibular stimulation was associated with better balance control for both techniques. …”
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    Functional Brain Activation in Response to a Clinical Vestibular Test Correlates with Balance
  19. 19399
    por Smith, Dirk, Helgason, Hannes, Sulem, Patrick, Bjornsdottir, Unnur Steina, Lim, Ai Ching, Sveinbjornsson, Gardar, Hasegawa, Haruki, Brown, Michael, Ketchem, Randal R., Gavala, Monica, Garrett, Logan, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Magnusson, Olafur T., Eyjolfsson, Gudmundur I., Olafsson, Isleifur, Onundarson, Pall Torfi, Sigurdardottir, Olof, Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn Runar, Ludviksdottir, Dora, Boezen, H. Marike, Heinzmann, Andrea, Krueger, Marcus, Porsbjerg, Celeste, Ahluwalia, Tarunveer S., Waage, Johannes, Backer, Vibeke, Deichmann, Klaus A., Koppelman, Gerard H., Bønnelykke, Klaus, Bisgaard, Hans, Masson, Gisli, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Johnston, James A., Jonsdottir, Ingileif, Stefansson, Kari
    Publicado 2017
    “…Through whole-genome sequencing and imputation into the Icelandic population, we found a rare variant in IL33 (NM_001199640:exon7:c.487-1G>C (rs146597587-C), allele frequency = 0.65%) that disrupts a canonical splice acceptor site before the last coding exon. …”
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    A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
  20. 19400
    “…CONCLUSION: INTS12 has functions beyond the canonical snRNA processing. We show that it regulates translation by regulating the expression of genes belonging to protein synthesis pathways. …”
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    Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways
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