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  1. 19561
    “…We found that the binding sequences for Δ1stTAD‐p53 are divergent and include not only the canonical p53 consensus binding sequences but also sequences similar to those recognized by a number of other known transcription factors. …”
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    Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain
  2. 19562
    por Diop, Fary, Moia, Riccardo, Favini, Chiara, Spaccarotella, Elisa, De Paoli, Lorenzo, Bruscaggin, Alessio, Spina, Valeria, Terzi-di-Bergamo, Lodovico, Arruga, Francesca, Tarantelli, Chiara, Deambrogi, Clara, Rasi, Silvia, Adhinaveni, Ramesh, Patriarca, Andrea, Favini, Simone, Sagiraju, Sruthi, Jabangwe, Clive, Kodipad, Ahad A., Peroni, Denise, Mauro, Francesca R., Giudice, Ilaria Del, Forconi, Francesco, Cortelezzi, Agostino, Zaja, Francesco, Bomben, Riccardo, Rossi, Francesca Maria, Visco, Carlo, Chiarenza, Annalisa, Rigolin, Gian Matteo, Marasca, Roberto, Coscia, Marta, Perbellini, Omar, Tedeschi, Alessandra, Laurenti, Luca, Motta, Marina, Donaldson, David, Weir, Phil, Mills, Ken, Thornton, Patrick, Lawless, Sarah, Bertoni, Francesco, Poeta, Giovanni Del, Cuneo, Antonio, Follenzi, Antonia, Gattei, Valter, Boldorini, Renzo Luciano, Catherwood, Mark, Deaglio, Silvia, Foà, Robin, Gaidano°, Gianluca, Rossi°, Davide
    Publicado 2020
    “…By immunoblotting analysis, we showed that the non-canonical nuclear factor-κB pathway is active in BIRC3-mutated cell lines and in primary CLL samples, as documented by the stabilization of MAP3K14 and by the nuclear localization of p52. …”
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    Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia
  3. 19563
    “…Network analysis revealed a total of 35 correlations among different fungal genera, with 27 (77.14%) positive and 8 (22.86%) negative pairwise interactions. Canonical correspondence analysis suggested that fungi in the faeces of pigs were more correlated to the concentration of acetate and butyrate rather than propionate. …”
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    The fungal community and its interaction with the concentration of short‐chain fatty acids in the faeces of Chenghua, Yorkshire and Tibetan pigs
  4. 19564
    “…CONCLUSIONS: Our results demonstrate that domain rearrangements are based on a canonical set of mutational events with rates which lie within a relatively narrow and consistent range. …”
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    The modular nature of protein evolution: domain rearrangement rates across eukaryotic life
  5. 19565
    “…All were demonstrated to be deleterious to function; the missense variants all disrupted the nuclear localisation of DONSON, while the intronic variant created a novel splice site that generated an out-of-frame transcript with no residual canonical transcript produced. CONCLUSION: Variants in DONSON have previously been associated with extreme microcephaly, short stature and limb anomalies and perinatal lethal microcephaly-micromelia syndrome. …”
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    Linked-read genome sequencing identifies biallelic pathogenic variants in DONSON as a novel cause of Meier-Gorlin syndrome
  6. 19566
    “…The recently discovered non-canonical axis of RAS with angiotensin-(1–7) and its receptor Mas, which is associated with cardioprotection could be essential to prevent damage to the heart following SCI. …”
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    Angiotensin-(1–7) Receptor Mas Deficiency Does Not Exacerbate Cardiac Atrophy Following High-Level Spinal Cord Injury in Mice
  7. 19567
    “…The basic fibroblast growth factor (FGF2) is a canonic member of the FGF family that plays a crucial role in various cellular processes, including organ development, wound healing, and tissue regeneration. …”
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    Fibroblast Growth Factor 2 Attenuates Renal Ischemia-Reperfusion Injury via Inhibition of Endoplasmic Reticulum Stress
  8. 19568
    “…The detection of high PD-L1 expression and lack of any canonical druggable driver mutations raises the potential of checkpoint immunotherapy for pulmonary lymphoepithelioma-like carcinoma.…”
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    A multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung
  9. 19569
    “…In Ovary DEGs were mainly involved in embryonic organ development, regulation of canonical Wnt signaling, response to peptide hormone. …”
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    Transcriptome analysis reveals differentially expressed genes associated with high rates of egg production in chicken hypothalamic-pituitary-ovarian axis
  10. 19570
    “…Structural analysis of vaccine-TLR4 receptor docked complex and its molecular dynamics simulation suggest sufficiently stable binding interface along with prospect of non-canonical receptor activation. Simulation dynamics of immune response following hypothetical immunization indicate active and memory B as well as CD4+ T cell generation potential, and likely chance of a more Th1 polarized response. …”
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    An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotes
  11. 19571
    “…CR mainly harbors a conserved poly-T stretch (15 bp), a short repeat unit (17 bp), some universal microsatellite-like repeats, and a canonical poly-A tail. Phylogenetic analysis using Bayesian inferences and maximum likelihood based on nucleotide and corresponding amino acid sequences of the 13 PCGs showed that E. impressicornis is closely related to E. chinensis, this relationship is and supported within Cucujiformia belonging to Meloidae (Tenebrionoidea). …”
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    Characterization of the Complete Mitochondrial Genome of Epicauta impressicornis (Coleoptera: Meloidae) and Its Phylogenetic Implications for the Infraorder Cucujiformia
  12. 19572
    “…Recently, we have generated a set of SL analogs, Methyl Phenlactonoates (MPs), which resemble the non-canonical SL carlactonoic acid. In this paper, we describe the development and characterization of a new series of easy-to-synthesize MPs. …”
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    A New Series of Carlactonoic Acid Based Strigolactone Analogs for Fundamental and Applied Research
  13. 19573
    “…The changes in photosynthetic pigment content of plants in remnant populations during the growth recovery phase and the entire growth period were similar to those occurring in photosynthetic activities in plants. Further, canonical correspondence analysis showed that photosynthetic physiological activities in the plants were significantly correlated with changes in water levels, emergence time, elevation gradient, soil water and soil nitrogen contents. …”
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    Spatiotemporal photosynthetic physiology responses of remnant Myricaria laxiflora populations to regulated water level fluctuations
  14. 19574
    “…Conclusion:IKBKE seems important for normal thyroid migration suggesting that the non-canonical NF-kB pathway might be implicated. Further studies targeting other genes in this pathway are ongoing to extend these results.…”
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    OR22-01 NF-κB Pathway Is Implicated in Thyroid Embryogenesis
  15. 19575
    “…The latest ultra-high-resolution CT (UHRCT) angiography (Aquilion Precision(TM); Canon Medical Systems) has recently become available for clinical testing of the main arteries and critical perforating arteries by brain CTA, compared to conventional CT. …”
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    NI-23 ULTRA-HIGH-RESOLUTION CT ANGIOGRAPHY FOR BRAIN TUMOR SURGERY
  16. 19576
    “…Such responses were detected also in freshly isolated mouse UCs, and found to be dependent on TRPV4, but not to require the canonical TLR4 signaling pathway of LPS detection. …”
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    TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides
  17. 19577
    “…Here, we found that Delta Like Non-Canonical Notch Ligand 1 (DLK1) expression was elevated as compared with normal brain in a genetically engineered mouse model of glioma, and that DLK1 expression increased with tumor grade in human glioma samples. …”
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    Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma
  18. 19578
    “…In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. …”
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    Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC
  19. 19579
    “…While the frequency of non-canonical GC-AG splice junctions represents about 0.8% of total splice sites in PCGs, we identified a significant enrichment of the GC-AG splice sites in long non-coding genes, both in human (3.0%) and mouse (1.9%). …”
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    GC-AG Introns Features in Long Non-coding and Protein-Coding Genes Suggest Their Role in Gene Expression Regulation
  20. 19580
    “…Furthermore, the neuroprotective effect of PNU282987 against Aβ aggregation was mediated by the canonical PI3K/Akt signaling pathway activation.…”
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    PNU282987 inhibits amyloid-β aggregation by upregulating astrocytic endogenous αB-crystallin and HSP-70 via regulation of the α7AChR, PI3K/Akt/HSF-1 signaling axis
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