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  1. 19701
    “…Four variants located in non-canonical splice sites of DYNC2H1, EVC, and KIAA0753 led to aberrant splicing that was shown by sequencing of cDNA. …”
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    High diagnostic yield in skeletal ciliopathies using massively parallel genome sequencing, structural variant screening and RNA analyses
  2. 19702
    “…However, studies for both disorders have not been fully consistent and have focused on few canonical markers with high relevance to the innate immune system, while the role of the adaptive immune system is studied less. …”
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    Common and disorder-specific upregulation of the inflammatory markers TRAIL and CCL20 in depression and schizophrenia
  3. 19703
    por Kundu, Siddhartha
    Publicado 2021
    “…ProTG4 can also provide a quantitative measure to identify and annotate the canonical form of a generic protein sequence from its known isoforms. …”
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    ProTG4: A Web Server to Approximate the Sequence of a Generic Protein From an in Silico Library of Translatable G-Quadruplex (TG4)-Mapped Peptides
  4. 19704
    “…GFB-887 is a podocyte-targeting, small molecule inhibitor of transient receptor potential canonical-5 (TRPC5) designed specifically to treat patients with glomerular kidney diseases characterized by an overactivation of the TRPC5-Rac1 pathway. …”
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    Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy: TRACTION-2 Trial Design
  5. 19705
    “…Although pathology of tauopathies is characterized by abnormal tau protein aggregation in both gray and white matter regions of the brain, neuropathological investigations have generally focused on abnormalities in the cerebral cortex because the canonical aggregates that form the diagnostic criteria for these disorders predominate there. …”
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    Deep learning reveals disease-specific signatures of white matter pathology in tauopathies
  6. 19706
    “…Paired Wilcoxon test, Spearman’s rank correlation, intraclass correlation and canonical correlation have been used. Bilateral symmetry and percent density (PD) were also evaluated. …”
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    Radiomic features of breast parenchyma: assessing differences between FOR PROCESSING and FOR PRESENTATION digital mammography
  7. 19707
    “…In the pre-glutamylation state structure of the SidJ-SdeA complex, adenylylated E860 of SdeA is inserted into the non-canonical (migrated) nucleotide-binding pocket of SidJ. …”
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    Structural basis for protein glutamylation by the Legionella pseudokinase SidJ
  8. 19708
    “…Moreover, ANP, BNP, CNP are able to improve and accelerate the dopaminergic differentiation and maturation of hiPSCs-derived neural population obtained from two differed healthy donors, concomitantly affecting the canonical Wnt signaling. Our results support the relevance of exogenous ANP, BNP, and CNP as attractive molecules for both neuroprotection and neurorepair in PD, and more in general, in NDs for which aberrant Wnt signaling seems to be the leading pathogenetic mechanism.…”
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    Natriuretic peptides are neuroprotective on in vitro models of PD and promote dopaminergic differentiation of hiPSCs-derived neurons via the Wnt/β-catenin signaling
  9. 19709
    “…Photographs were taken for each subject in the natural head position by a Canon EOS 1200 D camera set on a tripod at a distance of 1.5 m. …”
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    Evaluation of smile characteristics of skeletal Class III compared to skeletal Class I female adults
  10. 19710
    “…Poly(GR)-encoding sequences in the reporter RNAs caused translational stalling and generated ribosome-associated translation products, sharing molecular signatures with canonical RQC substrates. Furthermore, ZNF598 and listerin 1, the RQC E3 ubiquitin-protein ligase, promoted poly(GR) degradation via the ubiquitin-proteasome pathway. …”
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    ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD
  11. 19711
    “…We first identified 5933 CHs based on panel sequencing of matched DNA of white blood cell and cfDNA on 301 genes for 5100 patients, in which CH number of patients had positive correlation with their diagnosis age. We observed that canonical genes related to CH, including DNMT3A, TET2, ASXL1, TP53, ATM, CHEK2 and SF3B1, were dominant in the Chinese cohort and 13.29% of CH mutations only appeared in the Chinese cohort compared with the Western cohort. …”
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    Comprehensive landscape and interference of clonal haematopoiesis mutations for liquid biopsy: A Chinese pan‐cancer cohort
  12. 19712
    “…To explore this correlation further, genes expressed in these mDC subsets were used for feature selection prior to the construction of predictive models using supervised canonical correlation machine learning. The resulting models showed an improved correlation with serum antibody titers in response to full vaccination. …”
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    Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response
  13. 19713
    “…Nearly all editing sites represented the canonical A-to-I (n = 706) or C-to-U sites (n = 14). …”
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    The landscape of coding RNA editing events in pediatric cancer
  14. 19714
    “…The analysis on 20 TCs confirmed the intertumoral heterogeneity and a high percentage of copy number alterations (CNAs) in GBM canonical pathways. Comparing the genomic profiles of 14 TC-GSC pairs, we evidenced a robust similarity among the two samples of each patient. …”
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    Characterizing the Genomic Profile in High-Grade Gliomas: From Tumor Core to Peritumoral Brain Zone, Passing through Glioma-Derived Tumorspheres
  15. 19715
    “…We demonstrate in this MET-driven subset of EGFR TKI-refractory cancers that canonical EGFR downstream signaling was governed by MET, even in the presence of sustained mutant EGFR expression and activation. …”
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    Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
  16. 19716
    “…Wing shape variation among genera and species was analyzed using canonical variate analysis (CVA), while discriminant function analysis was used to cross-validate classification reliability based on Mahalanobis distances. …”
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    Geometric morphometric wing analysis as a tool to discriminate female mosquitoes from different suburban areas of Chiang Mai province, Thailand
  17. 19717
    “…METHODS: We analyzed expression of 20 canonical PRRs in tumor samples from 9502 patients of 33 tumor types. …”
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    Pattern Recognition Receptors (PRRs) in Macrophages Possess Prognosis and Immunotherapy Potential for Melanoma
  18. 19718
    “…The composition of the fungal community in rhizospheric soil with CF and RF applied was similar, but the richness and diversity of fungi were different. Canonical correspondence analysis (CCA) indicates there was a positive correlation between soil nutrition and fungal community structure. …”
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    Different Fertilizers Applied Alter Fungal Community Structure in Rhizospheric Soil of Cassava (Manihot esculenta Crantz) and Increase Crop Yield
  19. 19719
    por Sagna, Serge, Hantgan, Abbie
    Publicado 2021
    “…Additionally, we couch our results on multilingualism in the theory of canonical typology. FINDINGS/CONCLUSIONS: We propose a distinction between multilingual settings, e.g. communities where speakers are most likely to accommodate, and who live among villages largely located on national roads and around cities, and monolingual settings, which constitute most of the villages of the Casamance and where language acquisition is monolingual and where migration, rather than exogamy, accounts for the development of individual multilingualism. …”
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    African multilingualism viewed from another angle: Challenging the Casamance exception
  20. 19720
    “…Further, their local adaptation to different environmental variables and the partial contribution of climate and edaphic factors to the different agronomic traits was determined through canonical correspondence, redundancy analysis, and variation partitioning. …”
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    Deciphering Main Climate and Edaphic Components Driving Oat Adaptation to Mediterranean Environments
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