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  1. 19721
    “…Of the 325 significantly up regulated genes in DKD glomerulous (p < 0.05), 28 overlapped in PBMC and diabetic kidney, with perturbed FcER1 signaling as a significantly enriched canonical pathway. FcER1 was validated to be significantly increased in advanced DKD, where it was also seen to be specifically co-expressed in the kidney biopsy with tissue mast cells. …”
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    FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease
  2. 19722
    “…In mouse mast cells, it has been shown that tryptase, in addition to its canonical location in secretory granules, can be found in the nuclear compartment where it can impact on core histones. …”
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    Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
  3. 19723
    “…RNA-seq analysis on control and BMP2-treated primary human trophoblast cells identified 431 differentially expressed genes, including several canonical TGF-β/BMP signaling targets (BAMBI, ID1, INHBA, IGFBP3). …”
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    Dysregulated BMP2 in the Placenta May Contribute to Early-Onset Preeclampsia by Regulating Human Trophoblast Expression of Extracellular Matrix and Adhesion Molecules
  4. 19724
    “…Four woody plant communities were identified using free statistical software R version 3.1.1. The canonical correspondence analysis result showed that EC, pH, OM, altitude, C:N, CEC, sand, silt, AvP, and TN significantly affected species distribution in the watershed. …”
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    Woody species composition and community types of Hangadi Watershed, Guji Zone, Ethiopia
  5. 19725
    “…Here we studied Farsi, a language with canonical SOV word order. Because we were interested in the consequences of second-language acquisition, we compared monolingual native Farsi speakers and equally proficient bilinguals who had learned Farsi only after entering primary school. …”
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    First Event-Related Potentials Evidence of Auditory Morphosyntactic Processing in a Subject-Object-Verb Nominative-Accusative Language (Farsi)
  6. 19726
    “…The multiple host-guest interactions for C(2)H(2) in both inter- and intralayer cavities are further revealed by dispersion-corrected density functional theory and grand canonical Monte Carlo simulations. Dynamic breakthrough experiments show a clean C(2)H(2)/CO(2) separation with a high C(2)H(2) working capacity of 2.48 mmol g(−1).…”
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    Fine pore engineering in a series of isoreticular metal-organic frameworks for efficient C(2)H(2)/CO(2) separation
  7. 19727
    por Zhang, Chaofan, Jolly, Angad, Shayota, Brian J., Mazzeu, Juliana F., Du, Haowei, Dawood, Moez, Soper, Patricia Celestino, Ramalho de Lima, Ariadne, Ferreira, Bárbara Merfort, Coban-Akdemir, Zeynep, White, Janson, Shears, Deborah, Thomson, Fraser Robert, Douglas, Sarah Louise, Wainwright, Andrew, Bailey, Kathryn, Wordsworth, Paul, Oldridge, Mike, Lester, Tracy, Calder, Alistair D., Dumic, Katja, Banka, Siddharth, Donnai, Dian, Jhangiani, Shalini N., Potocki, Lorraine, Chung, Wendy K., Mora, Sara, Northrup, Hope, Ashfaq, Myla, Rosenfeld, Jill A., Mason, Kati, Pollack, Lynda C., McConkie-Rosell, Allyn, Kelly, Wei, McDonald, Marie, Hauser, Natalie S., Leahy, Peter, Powell, Cynthia M., Boy, Raquel, Honjo, Rachel Sayuri, Kok, Fernando, Martelli, Lucia R., Filho, Vicente Odone, Genomics England Research Consortium, Muzny, Donna M., Gibbs, Richard A., Posey, Jennifer E., Liu, Pengfei, Lupski, James R., Sutton, V. Reid, Carvalho, Claudia M.B.
    Publicado 2021
    “…Through human phenotype analyses of this RS cohort and OMIM clinical synopses of Mendelian disease, this study begins to tease apart specific biologic roles for non-canonical WNT-pathway proteins.…”
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    Novel pathogenic variants and quantitative phenotypic analyses of Robinow syndrome: WNT signaling perturbation and phenotypic variability
  8. 19728
    “…Our data identify an important role for tissue temperature in the epithelial restriction of SARS-CoV-2 independently of canonical interferon (IFN)-mediated antiviral immune defenses.…”
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    Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses
  9. 19729
    “…The genetic analysis revealed canonical somatic mutations of RB1 and germline variants of ALK (c.862 T > C), BLM (c.1021C > T), PTCH1 (c.152_154del), MSH2 (c.14C > A), RAD51C (c.635G > A). …”
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    Synchronous lung and multiple soft tissue metastases developed from osteosarcoma of tibia: a rare case report and genetic profile analysis
  10. 19730
    “…eIF4G2 (DAP5 or Nat1) is a homologue of the canonical translation initiation factor eIF4G1 in higher eukaryotes but its function remains poorly understood. …”
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    Ribosomal leaky scanning through a translated uORF requires eIF4G2
  11. 19731
    “…A genome-based search for G-protein subunit-coding genes revealed that M. truncatula and P. sativum harbored only one gene each for encoding the canonical heterotrimeric G-protein beta subunits, MtG beta 1 and PsG beta 1, respectively. …”
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    The Role of Heterotrimeric G-Protein Beta Subunits During Nodulation in Medicago truncatula Gaertn and Pisum sativum L.
  12. 19732
    “…Our investigation demonstrated a regulatory effect of GS on pro-inflammatory macrophages, which was extensively investigated in NAFLD that revealed intimate participation in the disease evolution, and the non-canonical IKK family member TANK-binding kinase 1 (TBK1) was involved in this process. …”
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    Gentiana scabra Restrains Hepatic Pro-Inflammatory Macrophages to Ameliorate Non-Alcoholic Fatty Liver Disease
  13. 19733
    “…Taken together, our study demonstrates that chitosan can up-regulate CAV1 expression, and CAV1 can interact with β-catenin for promotion of canonical Wnt signaling pathway activity. Our results deepens the molecular mechanism of the Wnt pathway in vascular endothelial cells and is beneficial to developing new targets to assist in enhancing the pharmacological effect of chitosan on wound healing and angiogenesis against DM.…”
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    Up-regulation of caveolin 1 mediated by chitosan activates Wnt/ β-catenin pathway in chronic refractory wound diabetic rat model
  14. 19734
    “…Community-weighted mean trait values and functional diversity indices were compared between the two sites. Canonical component analysis was performed to infer whether the changes of community traits and their relationships are driven by intraspecific variation or species turnover. …”
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    Strong Environmental Filtering Based on Hydraulic Traits Occurring in the Lower Water Availability of Temperate Forest Communities
  15. 19735
    “…Moreover, hypoxia elevated DIXDC1 expression and likely modulated both canonical Wnt/β-catenin signaling and VEGFR2 stability in vasculatures. …”
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    DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis
  16. 19736
    “…The disruptive effects of atypical work schedules extend beyond the expression profile of canonical circadian clock genes and affects other transcripts of the human genome. …”
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    Disturbance of the Circadian System in Shift Work and Its Health Impact
  17. 19737
    por Kroneck, Peter M. H.
    Publicado 2021
    “…Catalysis occurs at the distal side of a Fe(III) heme c proximally coordinated by lysine of a unique CXXCK motif (Sulfurospirillum deleyianum, Wolinella succinogenes) or, presumably, by the canonical histidine in Campylobacter jejeuni. Replacement of Lys by His in NrfA of W. succinogenes led to a significant loss of enzyme activity. …”
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    Nature's nitrite-to-ammonia expressway, with no stop at dinitrogen
  18. 19738
    “…We found strong relationship between cavin-2 and canonical signaling pathways ERK1/2, AKT, and STAT3 which are all known to be related to lung injury.…”
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    Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method
  19. 19739
    “…CONCLUSION: The biomarkers and canonical pathways identified in this study may hold the key to understanding the mechanisms of DCM pathobiology and providing new targets for the therapeutic effect of SPM against DCM by targeting abnormal immune response and signal transduction.…”
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    Spermine Regulates Immune and Signal Transduction Dysfunction in Diabetic Cardiomyopathy
  20. 19740
    “…We identified that PxGATAd directly activates PxmALP expression via interacting with a non-canonical but specific GATA-like cis-response element (CRE) located in the PxmALP promoter region. …”
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    MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression
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