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  1. 19841
    “…To achieve this, we perform Monte Carlo Grand Canonical calculations to obtain the adsorption isotherms of H[Formula: see text] , CO[Formula: see text] , and CH[Formula: see text] on the monolayers with and without strain. …”
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    Mechanical and gas adsorption properties of graphene and graphynes under biaxial strain
  2. 19842
    “…Detailed analysis of the Wnt pathway reveals differential regulation along the craniocaudal axis, which involves non-canonical Wnt signaling in determining cell fate in the proximal stomach. …”
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    DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
  3. 19843
    “…METHODS: Gnat1(rd17) and wildtype (WT) mice were studied in canonically low energy demand (light) and high energy demand (dark) conditions. …”
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    Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers
  4. 19844
    “…Sphingolipidomic analysis showed the coexistence of neurotoxic deoxy‐sphingolipids with an excess of canonical products of the SPT enzyme. l‐serine supplementation in patient fibroblasts reduced production of toxic 1‐deoxysphingolipids but further increased the overproduction of sphingolipids. …”
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    The SPTLC1 p.S331 mutation bridges sensory neuropathy and motor neuron disease and has implications for treatment
  5. 19845
    “…Pathway analysis was performed and cancer relevant canonical pathways for TIVA were identified. Target-mRNA analysis of VAG revealed a markedly worsened immunological response against cancer. …”
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    Anesthetic-specific lncRNA and mRNA profile changes in blood during colorectal cancer resection: A prospective, matched-case pilot study
  6. 19846
    “…Despite this persistent collagen presence, expression of canonical markers of fibrosis were also normalized. …”
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    Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2
  7. 19847
    “…High‐throughput quantitative proteomics revealed that S/GFP sEVs contained over 1000 proteins including canonical components of the exosomal pathway such as ALIX, syntenin‐1, and tetraspanins (CD81, CD9), but depleted for calnexin and cytochrome c. …”
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    Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS‐CoV‐2 spike protein
  8. 19848
    “…Our results show that the sialoside ring of NSANeuAc binds to the canonical sialyl binding pocket of the Siglec receptor family and that the high affinity arises from the accommodation of the NSA aromatic group in a nearby hydrophobic patch formed by the N-terminal tail and the unique G–G′ loop. …”
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    Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody
  9. 19849
    “…We found that EBP-1, the C. elegans ortholog of the canonical microtubule end binding protein EB1, promotes the specific association between kinesin-3/KIF1A/UNC-104 and Dense Core Vesicles (DCVs) prior to their axonal delivery. …”
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    End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles
  10. 19850
    “…Manual annotations of the clusters were performed using canonical gene markers. Cell type proportions, differential expression analysis, and gene ontology enrichment were carried out for each cell type. …”
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    Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naïve and Treated Crohn’s Disease
  11. 19851
    “…METHODS: Standard protocols were employed in collection and preparation of samples, generation of canonical strings, and conduction of microbiological analyses. …”
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    Antimicrobial analysis of honey against Staphylococcus aureus isolates from wound, ADMET properties of its bioactive compounds and in-silico evaluation against dihydropteroate synthase
  12. 19852
    “…The computational and functional analyses were performed to gain insights into the potential role of these dysregulated miRNAs in VS and have identified the “Apelin Liver Signaling Pathway” as the canonical pathway containing the most target genes regulated by these miRNAs. …”
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    MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting
  13. 19853
    “…Finally, the DSB recognition heterodimer cKU-70/80, but not the non-homologous end-joining canonical ligase LIG-4, contributes to the enriched off-center distribution of RAD-51 foci. …”
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    Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans
  14. 19854
    “…However, there is no canonical reference of gene expression in islet cell types in both health and disease that is also easily accessible for researchers to access, query, and use in bioinformatics pipelines. …”
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    An integrated map of cell type-specific gene expression in pancreatic islets
  15. 19855
    “…Based on the analysis of biological processes at 6 weeks PI in spleen and MLN in each infection group, canonical pathways were analyzed with ingenuity pathway analysis in the immune responses and metabolism especially lipid metabolism. …”
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    Immunopathological mechanisms in the early stage of Mycobacterium avium subsp. paratuberculosis infection via different administration routes in a murine model
  16. 19856
    “…Genes fitting BMC models were subjected to upstream regulator and canonical pathway analysis in Ingenuity Pathway Analysis. …”
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    In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals
  17. 19857
    “…We unexpectedly observed that upon both cold exposure and β(3)‐AR agonist administration, Prkd1 loss in BAT did not alter canonical thermogenic gene expression or adipocyte morphology. …”
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    Protein kinase D1 (Prkd1) deletion in brown adipose tissue leads to altered myogenic gene expression after cold exposure, while thermogenesis remains intact
  18. 19858
    “…A variety of post-translational modifications (PTMs), including acetylation, constitute a proposed histone code that is interpreted by “reader” proteins to modulate chromatin structure. Canonical histones can be replaced with variant versions that add an additional layer of regulatory complexity. …”
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    Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness
  19. 19859
    “…We used a pre-trained PGCN model to guide the design of TEV protease libraries for cleaving two non-canonical substrates, and found good agreement with experimental cleavage results. …”
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    Prediction and Design of Protease Enzyme Specificity Using a Structure-Aware Graph Convolutional Network
  20. 19860
    “…The results showed that MLKL and its phosphorylated protein p-MLKL were upregulated in the pancreas of the mouse AP model and cerulein-treated pancreatic acinar cells, independent of its canonical upstream molecule Ripk3, and appeared to function in a cell death-independent manner. …”
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    MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
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