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  1. 19901
    “…From each specimen, 36 linear morphometric measurements were taken. While a first canonical analysis of principal coordinates ruled out the possibility of different growth patterns between males and females, the same analysis statistically discriminated between small and large individuals in every species based on their morphology. …”
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    Ontogenetic Shifts in Body Morphology of Demersal Sharks’ Species (Order: Squaliformes) Inhabiting the Western-Central Mediterranean Sea, with Implications for Their Bio-Ecological Role
  2. 19902
    “…CONCLUSIONS: It is concluded that NiCl(2) induces p38 MAPK-dependent hemolysis, and stimulates the canonical features of premature eryptosis. This report presents the first description of the molecular mechanisms underlying the hemolytic and eryptotic potential of NiCl(2) and, thus, may explain changes in hematological parameters observed in poisoning victims.…”
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    INDUCTION OF HEMOLYSIS AND ERYPTOSIS BY OCCUPATIONAL POLLUTANT NICKEL CHLORIDE IS MEDIATED THROUGH CALCIUM INFLUX AND P38 MAP KINASE SIGNALING
  3. 19903
    “…Group A bonds are more indirect, whereas group B bonds are more like “normal” direct bonds. We used a Canon 700D camera, a biocompatible transparent 3D printing resin, and a 3M Gemini MBT.022 in bracket kit for CT scanning and imaging. …”
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    Three Dimensional Evaluation of Accuracy of Bracket Positioning
  4. 19904
    “…An analysis of publications as well as the paid and free software packages for modeling three-dimensional structures showed that most of them focus on working with unmodified proteins and canonical amino acid residues; the number of articles and software packages placing emphasis on modeling three-dimensional PTM structures is an order of magnitude smaller. …”
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    Modeling Side Chains in the Three-Dimensional Structure of Proteins for Post-Translational Modifications
  5. 19905
    “…Sclerostin and dickkopf-1 (DKK1), extracellular inhibitors of the canonical Wnt/β-catenin signaling pathway, have been associated with vascular aging and atherosclerosis. …”
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    Serum sclerostin level is positively associated with endothelial dysfunction measured by digital thermal monitoring in patients with type 2 diabetes: A prospective cross-sectional study
  6. 19906
    “…Genetic reversion is informed by a canonical reversion pathway defined by three gatekeeper mutations (A481G, U2909C, and U398C) and the accumulation of deleterious nonsynonymous mutations. …”
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    From vaccine to pathogen: Modeling Sabin 2 vaccine virus reversion and evolutionary epidemiology in Matlab, Bangladesh
  7. 19907
    por Martin, Joseph V., Sarkar, Pradip K.
    Publicado 2023
    “…We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) in the adult brain. …”
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    Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters?
  8. 19908
    “…Ingenuity pathway analysis on the differentially expressed genes in AC099850.4(high) TNBC revealed the activation of the canonical kinetochore metaphase signaling pathway, pyridoxal 5'-phosphate salvage pathway, and salvage pathways of pyrimidine ribonucleotides. …”
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    Long non-coding RNA AC099850.4 correlates with advanced disease state and predicts worse prognosis in triple-negative breast cancer
  9. 19909
    “…These data indicate that PD 102807 transduces a signaling pathway (AMPK-mediated mTORC1 inhibition) qualitatively distinct from canonical M3 mAChR signaling to prevent pathogenic remodeling of ASM, thus demonstrating PD 102807 is a biased M3 mAChR ligand with therapeutic potential for the management of obstructive airway disease.…”
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    The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype
  10. 19910
    “…Our data confirm that L-T(4) is necessary and sufficient for recovering memory and hippocampal neurogenesis deficits associated with hypothyroidism, while we found no evidence to support the role of non-canonical TH signalling.…”
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    Effect of Combined Levothyroxine (L-T(4)) and 3-Iodothyronamine (T(1)AM) Supplementation on Memory and Adult Hippocampal Neurogenesis in a Mouse Model of Hypothyroidism
  11. 19911
    “…Seven novel DIVs and six novel non-canonical splice site variants were detected in a total of 35 alleles and characterized, including the c.6283-321C>G variant leading to a complex splicing defect. …”
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    Targeted sequencing and in vitro splice assays shed light on ABCA4-associated retinopathies missing heritability
  12. 19912
    “…By performing co‐immunoprecipitation assays, the change in the ubiquitin levels of the Jagged canonical Notch ligand 1 (Jag 1), caused by SNORA73B and MIB1, was identified. …”
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    SNORA73B promotes endometrial cancer progression through targeting MIB1 and regulating host gene RCC1 alternative splicing
  13. 19913
    “…In conclusion, WNT16b enhances the proliferation and maintains the stemness of hLESCs by activating the non‐canonical calcium/calcineurin A/NFATC2 pathway in vitro and in vivo, and accelerates corneal epithelial wound healing.…”
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    WNT16b promotes the proliferation and self‐renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway
  14. 19914
    “…Furthermore, this approach bridges canonical fMRI experiments with electrophysiological experiments, which in turn allows novel avenues for studying human physiology non‐invasively.…”
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    A selection and targeting framework of cortical locations for line‐scanning fMRI
  15. 19915
    “…The tumor cell lines were grouped into three subsets by their canonical E-selectin ligand status (sialyl-Lewis A and X +/+, −/+, −/−) and their adhesiveness was compared after enzymatic, pharmacologic, chemical treatment or antibody blockade of the tumor cells or endothelial cells, respectively. …”
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    Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells
  16. 19916
    “…We retrieved all the protein-coding Ensembl transcripts and mapped Interpro domains and post-translational modifications on canonical sequences to identify functionally relevant splicing events. …”
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    EXPANSION: a webserver to explore the functional consequences of protein-coding alternative splice variants in cancer genomics
  17. 19917
    “…Most studies were of good quality. fMRI-FC analysis pipelines included seed-based-, independent component- / canonical correlation analysis, network-based statistics, and graph-theoretical approaches. …”
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    fMRI connectivity as a biomarker of antipsychotic treatment response: A systematic review
  18. 19918
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    Determination of Haematological Reference Values for Tucúquere (Bubo magellanicus) Habiting in Central Chile
  19. 19919
    “…Introduction: The conversion of dietary inorganic nitrate (NO3-) to nitric oxide (NO) is a non-canonical pathway that plays an important role in NO biology, especially under pathological conditions. …”
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    Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide: An Open-Label Clinical Trial Among Hypertensive Subjects
  20. 19920
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    How myosin VI traps its off-state, is activated and dimerizes
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