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  1. 19941
    “…However, the isoforms apparently play different non-canonical roles in apoptosis and cancer development which are awaiting further investigations. …”
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    A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules
  2. 19942
    “…Predictions about the biological behavior of GIST are based on a number of canonical clinical and pathologic parameters whose validity in distinguishing between a benign and a malignant tumour is still imperfect. …”
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    Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours
  3. 19943
    “…We also found evidence for a canonical configuration of the origin and terminus of replication. …”
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    Dynamics of Genome Rearrangement in Bacterial Populations
  4. 19944
    por Yu, Yau-Hua, Kuo, Hsu-Ko, Chang, Kuo-Wei
    Publicado 2008
    “…CONCLUSIONS: By means of a systems-biology approach via network-based meta-analyses, we provided a deeper insight into the evolving nature of the HNSCC transcriptome. Enriched canonical signaling pathways, hot-spots of transcriptional profiles across the genome, as well as topologically significant genes derived from network analyses were highlighted for each of the three progressive stages, Pre, TvN, and Meta, respectively.…”
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    The Evolving Transcriptome of Head and Neck Squamous Cell Carcinoma: A Systematic Review
  5. 19945
    “…Treating cells with PHA-665752, a specific c-Met receptor tyrosine kinase inhibitor, significantly abrogated the enhancement of TRAIL-induced cell death by HGF, indicating that its death promoting effect requires activation of its canonical receptor tyrosine kinase. Cell death induced by TRAIL+HGF was predominately apoptotic involving both extrinsic and intrinsic pathways as evidenced by the increased activation of caspase-3, 8, 9. …”
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    Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5
  6. 19946
    “…Capitella Hox genes have maintained a clustered organization, are expressed in the canonical anterior–posterior order found in other metazoans, and exhibit spatial and temporal colinearity, reflecting Hox gene characteristics that likely existed in the protostome–deuterostome ancestor.…”
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    Genomic Organization and Expression Demonstrate Spatial and Temporal Hox Gene Colinearity in the Lophotrochozoan Capitella sp. I
  7. 19947
    “…The canonical sequence LSGGQ, also known as the signature sequence, defines the adenosine triphosphate (ATP)-binding cassette transporter superfamily. …”
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    Mutations at the Signature Sequence of CFTR Create a Cd(2+)-gated Chloride Channel
  8. 19948
    “…This has been demonstrated using nanopatterned RGD peptides, a canonical extracellular matrix ligand for integrin interactions. …”
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    Cell adhesion to agrin presented as a nanopatterned substrate is consistent with an interaction with the extracellular matrix and not transmembrane adhesion molecules
  9. 19949
    “…These findings support the notion that canonical initiation takes place when the subgenomic mRNA is translated out of the infection context, while initiation can occur without some eIFs and even at non-AUG codons in infected cells.…”
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    Dual Mechanism for the Translation of Subgenomic mRNA from Sindbis Virus in Infected and Uninfected Cells
  10. 19950
    “…Genes involved in the PI3K pathway, insulin/IGF pathway, carbohydrate metabolism and apoptosis regulation were up-regulated. Genes belonging to canonical Wnt, calcium signalling pathways and cytokine-receptor cytokine interaction were down-regulated. …”
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    Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets
  11. 19951
    “…For a previously unpublished BMP6 study, GAGE predicted novel regulatory mechanisms for BMP6 induced osteoblast differentiation, including the canonical BMP-TGF beta signaling, JAK-STAT signaling, Wnt signaling, and estrogen signaling pathways–all of which are supported by the experimental literature. …”
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    GAGE: generally applicable gene set enrichment for pathway analysis
  12. 19952
    “…Experimental conditions involving binary mixtures of alkali and/or alkaline earth metal ions are computed using equilibrium Monte Carlo simulations in the grand canonical ensemble. The model pore rejects alkali metal ions in the presence of biological concentrations of Ca(2+) and predicts the blockade of alkali metal ion currents by micromolar Ca(2+). …”
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    Ionic selectivity in L-type calcium channels by electrostatics and hard-core repulsion
  13. 19953
    “…Here we present a novel ORA, protein interaction permutation analysis (PIPA), that takes advantage of canonical pathways and established protein interactions to identify pathways enriched for protein interactions connecting RNAi hits. …”
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    Knowledge based identification of essential signaling from genome-scale siRNA experiments
  14. 19954
    “…Homer proteins couple extracellular receptors – such as metabotropic glutamate receptors and the transient receptor potential canonical family of cation channels – to intracellular receptors such as inositol triphosphate and ryanodine receptors on intracellular calcium stores and, therefore, are well placed to regulate calcium dynamics within the neural growth cone. …”
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    Homer regulates calcium signalling in growth cone turning
  15. 19955
    “…Overall, our experiments suggest that, unlike fibroblasts and cortical neurons, IFN-β gene regulation after WNV infection in myeloid cells is IPS-1-dependent but does not require full occupancy of the IFN-β enhanceosome by canonical constituent transcriptional factors.…”
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    Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7
  16. 19956
    “…However, none of the canonical pro-myogenic transcription factors (MYOD1, MYOG, MYF5, MYF6 and MEF2C) were linked to muscle structural gene expression modules. …”
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    Inferring the Transcriptional Landscape of Bovine Skeletal Muscle by Integrating Co-Expression Networks
  17. 19957
    “…A statistical framework based on Monte-Carlo estimations of the uncertainty ellipsoid confirmed the superiority of optimally designed experiments over canonical inputs. The proposed approach can be easily extended to multiobjective formulations that can also take advantage of identifiability analysis. …”
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    Developing optimal input design strategies in cancer systems biology with applications to microfluidic device engineering
  18. 19958
    “…Notch signaling, actin cytoskeleton signaling, pentose phosphate pathway, axonal guidance signaling and integrin signaling were the top-five canonical pathways significantly regulated by estrogen. …”
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    Estradiol Stimulates Vasodilatory and Metabolic Pathways in Cultured Human Endothelial Cells
  19. 19959
    “…Progression of colon cancer from microadenoma to macroscopic tumors is coupled to augmentation of canonical Wnt signaling. We recently reported that tumor associated macrophages, through interleukin 1β (IL-1β) dependent phosphorylation of GSK3β, promote Wnt signaling in colon cancer cells, demonstrating that proinflammatory cytokines can enhance TCF4/β-catenin transcriptional activity in tumor cells. …”
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    The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β
  20. 19960
    “…The elucidation of the mechanisms that control osteoblast number is of major interest for the treatment of skeletal disorders characterized by abnormal bone formation. Canonical Wnt signalling plays an important role in the control of osteoblast proliferation, differentiation and survival. …”
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    N-Cadherin Negatively Regulates Osteoblast Proliferation and Survival by Antagonizing Wnt, ERK and PI3K/Akt Signalling
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