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1“…We find that unless a sufficient fraction of negative results are published, false claims frequently can become canonized as fact. Data-dredging, p-hacking, and similar behaviors exacerbate the problem. …”
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3“…Here we will give an overview of canonical and alternative Reelin signaling pathways, molecular mechanisms involved, and their potential physiological roles in the context of different biological settings.…”
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5“…AIM OF THE REVIEW: The study and understanding of the canonical and non-canonical functions of NLRP3 can help to better understand its involvement in various pathologies. …”
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6por Kobayashi, Hisato“…To further understand DNA methylation-dependent (canonical) and -independent (non-canonical) imprints, this review summarizes the loci under the control of each type of imprinting in the mouse and compares them with the respective homologs in other rodents. …”
Publicado 2021
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7“…Here, we analyzed cortical lysates from young (3 months old), aged (18 months old), and aged anti-ASC treated mice for the expression of canonical and non-canonical inflammasome proteins. …”
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8“…We use Approximate Entropy to measure the (un)predictability in two aesthetic text categories, i.e., canonical fiction (‘classics’) and non-canonical fiction (with lower prestige). …”
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9por Richard Albert, Julien, Kobayashi, Toshihiro, Inoue, Azusa, Monteagudo-Sánchez, Ana, Kumamoto, Soichiro, Takashima, Tomoya, Miura, Asuka, Oikawa, Mami, Miura, Fumihito, Takada, Shuji, Hirabayashi, Masumi, Korthauer, Keegan, Kurimoto, Kazuki, Greenberg, Maxim V. C., Lorincz, Matthew, Kobayashi, Hisato“…However, only 3 paternally expressed imprinted genes are conserved in the extraembryonic tissue of murids, all of which are associated with non-canonical H3K27me3 imprints. The discovery of 8 novel non-canonical imprinted genes unique to the rat is consistent with more rapid evolution of extraembryonic imprinting. …”
Publicado 2023
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10por Rusiecka, Olga M., Montgomery, Jade, Morel, Sandrine, Batista-Almeida, Daniela, Van Campenhout, Raf, Vinken, Mathieu, Girao, Henrique, Kwak, Brenda R.Enlace del recurso
Publicado 2020
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11“…As one of the predominant GRK family members expressed in immune cells, GRK2′s canonical and noncanonical actions play an especially significant role in normal immune cell function as well as in the development and progression of disorders of the immune system. …”
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19“…HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response.…”
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20por Akincilar, Semih Can, Chan, Claire Hian Tzer, Ng, Qin Feng, Fidan, Kerem, Tergaonkar, Vinay“…To circumvent this concern, an alternative strategy could be to target the molecules involved in the non-canonical functions of telomeric proteins. In this review, we will focus on emerging evidence that has demonstrated the non-canonical roles of telomeric proteins and their impact on tumorigenesis. …”
Publicado 2021
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