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146781Publicado 2017“…Why do nasopharyngeal carcinomas rarely metastasize to the brain? Question 7. …”
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146782por Peng, Fei, Li, Ting-Ting, Wang, Kai-Li, Xiao, Guo-Qing, Wang, Ju-Hong, Zhao, Hai-Dong, Kang, Zhi-Jie, Fan, Wen-Jun, Zhu, Li-Li, Li, Mei, Cui, Bai, Zheng, Fei-Meng, Wang, Hong-Jiang, Lam, Eric W-F, Wang, Bo, Xu, Jie, Liu, Quentin“…Appropriately, H19 and LIN28 expression exhibits strong correlations in primary breast carcinomas. Collectively, these findings reveal that lncRNA H19, miRNA let-7 and transcriptional factor LIN28 form a double-negative feedback loop, which has a critical role in the maintenance of BCSCs. …”
Publicado 2017
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146783por Yang, C, Li, Z, Bhatt, T, Dickler, M, Giri, D, Scaltriti, M, Baselga, J, Rosen, N, Chandarlapaty, S“…Dysregulated activation of the CDK4/6 kinases is a hallmark of most mammary-derived carcinomas. ATP-competitive inhibitors against this complex have been recently advanced in the clinic and have shown significant activity, particularly against tumors driven by the estrogen receptor (ER). …”
Publicado 2017
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146784por Li, Niu, Xu, Yufei, Li, Guoqiang, Yu, Tingting, Yao, Ru-en, Wang, Xiumin, Wang, Jian“…Previous studies have shown that gain-of-function mutations in the CTNNB1 gene contribute to the occurrence and development of a variety of carcinomas in humans. Recently, de novo, heterozygous, loss-of-function mutations of the CTNNB1 gene were found that partially explain intellectual disability in some patients. …”
Publicado 2017
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146785por Brouwers, Barbara, Fumagalli, Debora, Brohee, Sylvain, Hatse, Sigrid, Govaere, Olivier, Floris, Giuseppe, Van den Eynde, Kathleen, Bareche, Yacine, Schöffski, Patrick, Smeets, Ann, Neven, Patrick, Lambrechts, Diether, Sotiriou, Christos, Wildiers, Hans“…METHODS: We compared gene expression profiles in stromal fields of breast carcinomas by performing laser capture microdissection of the cancer-associated stroma from eight old (aged ≥80 years at diagnosis) and nine young (aged <45 years at diagnosis) patients with triple-negative breast cancer. …”
Publicado 2017
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146786por Sukhbaatar, Nyamdelger, Bachmayr-Heyda, Anna, Auer, Katharina, Aust, Stefanie, Deycmar, Simon, Horvat, Reinhard, Pils, Dietmar“…We conclude that this mutually exclusive distribution of two different TP53 mutations in different tumor tissues indicates the development of two independent carcinomas in the peritoneal cavity, probably one originating from a precancerous lesion in the fallopian tube and the other from the ovaries. …”
Publicado 2017
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146787por Pareja, Fresia, Geyer, Felipe C, Marchiò, Caterina, Burke, Kathleen A, Weigelt, Britta, Reis-Filho, Jorge S“…Secretory and adenoid cystic carcinomas are two histologic types of TNBCs underpinned by specific fusion genes; these tumors have an indolent clinical behavior and lack all of the cardinal molecular features of high-grade triple-negative disease. …”
Publicado 2016
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146788por Moreno-Marín, Nuria, Barrasa, Eva, Morales-Hernández, Antonio, Paniagua, Beroé, Blanco-Fernández, Gerardo, Merino, Jaime M., Fernández-Salguero, Pedro M.“…Liver carcinogenesis induced by diethylnitrosamine (DEN) produced large carcinomas in all AhR−/− mice but mostly premalignant adenomas in less than half of AhR+/+ mice. …”
Publicado 2017
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146789por Carloni, Silvia, Gallerani, Giulia, Tesei, Anna, Scarpi, Emanuela, Verdecchia, Giorgio Maria, Virzì, Salvatore, Fabbri, Francesco, Arienti, Chiara“…RESULTS: No significant correlation was found between ploidy or SPF and patient characteristics, even though primary carcinomas were mainly hyperdiploid and more proliferative than recurrent tumors. …”
Publicado 2017
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146790por Zhang, Yunyuan, Lun, Limin, Li, Hui, Wang, Qing, Lin, Jieru, Tian, Runhua, Pan, Huazheng, Zhang, Haiping, Chen, Xian“…The present meta-analysis aimed to analyze available data to identify the prognostic role of NEAT1 in multiple carcinomas. A systematic search was performed by using several computerized databases from inception to June 7, 2017. …”
Publicado 2017
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146791por Kundu, Snehangshu, Ali, Muhammad Akhtar, Handin, Niklas, Padhan, Narendra, Larsson, Jimmy, Karoutsou, Maria, Ban, Kenneth, Wiśniewski, Jacek R., Artursson, Per, He, Liqun, Hellström, Mats, Sjöblom, Tobias“…BACKGROUND: The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations in genes hitherto unknown to belong to the pathway. …”
Publicado 2018
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146792por Adilbay, Dauren, Adilbayev, Galim, Kidirbayeva, Gulzhan, Shipilova, Viktoria, Sadyk, Zhanat, Koyanbekova, Gulsum, Sokolenko, Ekaterina, Klozar, Jan“…The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. …”
Publicado 2018
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146793“…Patients with Fanconi anemia and dyskeratosis congenita developed head and neck and anogenital squamous cell carcinomas at rates that were hundreds-fold greater than those of the general population. …”
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146794por Peng, F, Wang, J-H, Fan, W-J, Meng, Y-T, Li, M-M, Li, T-T, Cui, B, Wang, H-F, Zhao, Y, An, F, Guo, T, Liu, X-F, Zhang, L, Lv, L, Lv, D-K, Xu, L-Z, Xie, J-J, Lin, W-X, Lam, E W-F, Xu, J, Liu, Q“…Accordingly, H19 and PDK1 expression exhibits strong correlations in primary breast carcinomas. H19 acting as a competitive endogenous RNA sequesters miRNA let-7 to release Hypoxia-inducible factor 1α, leading to an increase in PDK1 expression. …”
Publicado 2018
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146795por Dong, Jun, Geng, Xiaojing, Yang, Yadi, Cai, Xiuyu, Hu, Pili, Xia, Liangping, Zhang, Bei, Wu, Peihong“…BACKGROUND: Magnetic resonance (MR)-guided microwave ablation is a well-developed technique for the treatment of tumors, especially hepatic carcinomas. However, there are no detailed reports on the changes in the MR images and histology observed after the ablation. …”
Publicado 2018
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146796por Varlotto, John Michael, Voland, Richard, McKie, Kerrie, Flickinger, John C., DeCamp, Malcolm M., Maddox, Debra, Rava, Paul, Fitzgerald, Thomas J., Graeber, Geoffrey, Rassaei, Negar, Oliveira, Paulo, Ali, Suhail, Belani, Chandra, Glanzman, Jonathan, Wakelee, Heather A., Patel, Manali, Baima, Jennifer, Zhang, Jianying, Walsh, William“…Compared to Whites, Blacks were more likely to present with younger age, male sex, lower income, no insurance, single/widowed partnership, less squamous cell carcinomas, and advanced stage; and experience less definitive surgery, lower OS, and lung cancer‐specific (LCSS) survival. …”
Publicado 2018
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146797por Bambara, Hierrhum Aboubacar, Zouré, Abdou Azaque, Sawadogo, Alexis Yobi, Ouattara, Abdoul Karim, Ouédraogo, Nabonswindé Lamoussa Marie, Traoré, Si Simon, Bakri, Youssef, Simpore, Jacques“…The clinical and molecular characteristics showed that left-sided breast cancer accounted for 51.25 %, high grade (II and III) represented 93.75 % of cases and the majority of tumors were infiltrating ductal carcinomas (93.75%) with stages III and IV accounted for 50.0%. …”
Publicado 2017
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146798por Albers, Andreas E., Qian, Xu, Kaufmann, Andreas M., Mytilineos, Daphne, Ferris, Robert L., Hoffmann, Thomas K., DeLeo, Albert B.“…CD8(+) cytotoxic T-cell (CTL) specific for non-mutated, wild type (wt) sequence p53 peptides derived from wt or mutant p53 molecules expressed in head and neck squamous cell carcinomas (HNSCC) have been detected in the circulation of patients with this disease. …”
Publicado 2018
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146799por Torres, Kátia Luz, Mariño, Josiane Montanho, Pires Rocha, Danielle Albuquerque, de Mello, Mônica Bandeira, de Melo Farah, Heydy Halanna, Reis, Renato dos Santos, Alves, Valquíria do Carmo Rodrigues, Gomes, Edson, Martins, Toni Ricardo, Soares, Ana Carolina, de Oliveira, Cristina Mendes, Levi, José Eduardo“…Histopathological analysis revealed 2 CIN3, 2 carcinomas and 5 CIN1. OncoE6 called two out of the three HPV 16 or 18 associated CIN3+ lesions. …”
Publicado 2018
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146800por Biermann, Jana, Parris, Toshima Z., Nemes, Szilárd, Danielsson, Anna, Engqvist, Hanna, Werner Rönnerman, Elisabeth, Forssell-Aronsson, Eva, Kovács, Anikó, Karlsson, Per, Helou, Khalil“…BACKGROUND: Molecular classification of tumour clonality is currently not evaluated in multiple invasive breast carcinomas, despite evidence suggesting common clonal origins. …”
Publicado 2018
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