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146881por Po, Wah Wah, Choi, Won Seok, Khing, Tin Myo, Lee, Ji-Yun, Lee, Jong Hyuk, Bang, Joon Seok, Min, Young Sil, Jeong, Ji Hoon, Sohn, Uy Dong“…Gastric adenocarcinoma is among the top causes of cancer-related death and is one of the most commonly diagnosed carcinomas worldwide. Benzyl isothiocyanate (BITC) has been reported to inhibit the gastric cancer metastasis. …”
Publicado 2022
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146882por Lee, Kyung-Woo, Hong, Hui-Ra, Lim, Ji-Sun, Ko, Kyung-Phil, Lee, Min-Goo, Chi, Sung-Gil“…XAF1 and GRP78 expression show an inverse correlation in human cancer cell lines and primary breast carcinomas. Collectively this study uncovers an important role for XAF1 as a linchpin to govern the sensitivity to ER stress and the outcomes of UPR signaling, illuminating the mechanistic consequence of XAF1 inactivation in tumorigenesis.…”
Publicado 2022
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146883“…Data of 1796 consecutive CRC patients referred to our center from November 11th, 2004, to December 31st, 2017, were analyzed. Right-sided carcinomas are more frequent in women than in men; furthermore, women had a lower surgical complication rate. …”
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146884por Montero‐Conde, Cristina, Leandro‐García, Luis Javier, Martínez‐Montes, Ángel M., Martínez, Paula, Moya, Francisco J., Letón, Rocío, Gil, Eduardo, Martínez‐Puente, Natalia, Guadalix, Sonsoles, Currás‐Freixes, Maria, García‐Tobar, Laura, Zafon, Carles, Jordà, Mireia, Riesco‐Eizaguirre, Garcilaso, González‐García, Patricia, Monteagudo, María, Torres‐Pérez, Rafael, Mancikova, Veronika, Ruiz‐Llorente, Sergio, Pérez‐Martínez, Manuel, Pita, Guillermo, Galofré, Juan Carlos, Gonzalez‐Neira, Anna, Cascón, Alberto, Rodríguez‐Antona, Cristina, Megías, Diego, Blasco, María A., Caleiras, Eduardo, Rodríguez‐Perales, Sandra, Robledo, Mercedes“…Quantitative‐FISH (fluorescence in situ hybridization) analysis of telomere lengths showed a significant shortening in these carcinomas, which matched with a high proliferative rate measured by Ki‐67 immunohistochemistry. …”
Publicado 2022
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146885por Bogdanova, Tetiana, Chernyshov, Serhii, Zurnadzhy, Liudmyla, Rogounovitch, Tatiana I., Mitsutake, Norisato, Tronko, Mykola, Ito, Masahiro, Bolgov, Michael, Masiuk, Sergii, Yamashita, Shunichi, Saenko, Vladimir A.“…At the same time, current clinical guidelines tend to consider prior radiation exposure as a contraindication to less extensive surgery, even for low-risk thyroid carcinomas, which primarily include microcarcinomas. …”
Publicado 2022
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146886“…ARID1A is the most commonly mutated chromatin remodeler gene, exhibiting the highest mutation frequency in endometrium-related uterine and ovarian carcinomas. As a tumor suppressor gene, ARID1A is essential for regulating cell cycle, facilitating DNA damage repair, and controlling expression of genes that are essential for maintaining cellular differentiation and homeostasis in non-transformed cells. …”
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146887“…Numerous studies have shown that improper activation of Notch signaling may lead to excessive cell proliferation and cancer, with tumor-promoting and tumor-suppressive effects in various carcinomas. Thus, inhibitors of Notch signaling are actively being investigated for the treatment of various tumors. …”
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146888por Schoonbeek, Rosanne C., de Vries, Julius, Bras, Linda, Sidorenkov, Grigory, Plaat, Boudewijn E. C., Witjes, Max J. H., van der Laan, Bernard F. A. M., van den Hoek, Johanna G. M., van Dijk, Boukje A. C., Langendijk, Johannes A., Halmos, György B.“…OBJECTIVE: Head and neck squamous cell carcinomas (HNSCC) are rapidly developing tumours, and substantial delay in treatment initiation is associated with decreased overall survival. …”
Publicado 2022
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146889por Vernemmen, Astrid I P, Li, Xiaofei, Roemen, Guido M J M, Speel, Ernst‐Jan M, Kubat, Bela, zur Hausen, Axel, Winnepenninckx, Véronique J L, Samarska, Iryna V“…In 19 patients, the cutaneous metastasis was the first presentation of a clinically silent internal malignancy (18.6%), of which most (78.9%) represented metastatic lung carcinomas. Finally, metastasizing patterns were different across tumour types and gender. …”
Publicado 2022
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146890por Murgaski, Aleksandar, Kiss, Máté, Van Damme, Helena, Kancheva, Daliya, Vanmeerbeek, Isaure, Keirsse, Jiri, Hadadi, Eva, Brughmans, Jan, Arnouk, Sana M., Hamouda, Ahmed E.I., Debraekeleer, Ayla, Bosteels, Victor, Elkrim, Yvon, Boon, Louis, Hoves, Sabine, Vandamme, Niels, Deschoemaeker, Sofie, Janssens, Sophie, Garg, Abhishek D., Vande Velde, Greetje, Schmittnaegel, Martina, Ries, Carola H., Laoui, Damya“…Hence, distinct cDC subsets contributed to the induction of αCD40 responses. In contrast, lung carcinomas, characterized by a high abundance of macrophages, were resistant to αCD40 therapy. …”
Publicado 2022
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146891por Yao, James, Bergsland, Emily, Aggarwal, Rahul, Aparicio, Ana, Beltran, Himisha, Crabtree, Judy S, Hann, Christine L, Ibrahim, Toni, Byers, Lauren A, Sasano, Hironobu, Umejiego, John, Pavel, Marianne“…INTRODUCTION: Neuroendocrine neoplasms (NEN) are heterogeneous malignancies that can arise at almost any anatomical site and are classified as biologically distinct well-differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC). Current systemic therapies for advanced disease, including targeted therapies, chemotherapy, and immunotherapy, are associated with limited duration of response. …”
Publicado 2022
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146892“…Inhibitors of the non-coding RNAs, DNA methyltransferases, and histone deacetylases combined with PD-1/PD-L1 inhibitors have shown considerable therapeutic efficacy against carcinomas as well as blood cancers. Importantly, DNA methylation-mediated epigenetic silencing can inhibit antigen processing and presentation, which promotes cancerogenesis and aggravates resistance to PD-1/PD-L1 blockade immunotherapy. …”
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146893por Sannigrahi, Malay K., Rajagopalan, Pavithra, Lai, Ling, Liu, Xinyi, Sahu, Varun, Nakagawa, Hiroshi, Jalaly, Jalal B., Brody, Robert M., Morgan, Iain M., Windle, Bradford E., Wang, Xiaowei, Gimotty, Phyllis A., Kelly, Daniel P., White, Elizabeth A., Basu, Devraj“…Therapy with radiation plus cisplatin kills HPV(+) oropharyngeal squamous cell carcinomas (OPSCCs) by increasing reactive oxygen species beyond cellular antioxidant capacity. …”
Publicado 2022
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146894por Bergsten, Tova M., Levy, Sarah E., Zink, Katherine E., Lusk, Hannah J., Pergande, Melissa R., Cologna, Stephanie M., Burdette, Joanna E., Sanchez, Laura M.“…As only the fimbriated distal ends of the fallopian tube that reside in close proximity to the ovary develop precursor lesions such as serous tubal intraepithelial carcinomas, this suggests that the process of transformation and primary metastasis to the ovary is impacted by the local microenvironment. …”
Publicado 2022
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146895por Hennuy, Camille, Defrère, Pierre, Maweja, Sylvie, Thiry, Albert, Gennigens, Christine“…Its diagnosis is often difficult because it shares many clinical and radiologic aspects with breast carcinomas and therefore relies on anatomopathological analysis which may be supplemented by genetic analysis. …”
Publicado 2022
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146896por Jochumsen, Mads Ryø, Overgaard, David Lyse, Vendelbo, Mikkel Holm, Madsen, Michael Alle, Tolbod, Lars Poulsen, Gormsen, Lars Christian, Barkholt, Trine Ørhøj“…Various malignant lesions with increased perfusion were detected, including lymphomas, large-celled neuroendocrine tumour, breast, and lung cancer plus metastases from colonic and renal cell carcinomas. Furthermore, inflammatory and hyperplastic benign conditions with increased perfusion were observed: rib fractures, gynecomastia, atelectasis, sarcoidosis, pneumonia, chronic lung inflammation and fibrosis, benign lung nodule, chronic diffuse lung infiltrates, pleural plaques and COVID-19 infiltrates. …”
Publicado 2023
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146897por Spielvogel, Clemens P., Stoiber, Stefan, Papp, Laszlo, Krajnc, Denis, Grahovac, Marko, Gurnhofer, Elisabeth, Trachtova, Karolina, Bystry, Vojtech, Leisser, Asha, Jank, Bernhard, Schnoell, Julia, Kadletz, Lorenz, Heiduschka, Gregor, Beyer, Thomas, Hacker, Marcus, Kenner, Lukas, Haug, Alexander R.“…PURPOSE: Head and neck squamous cell carcinomas (HNSCCs) are a molecularly, histologically, and clinically heterogeneous set of tumors originating from the mucosal epithelium of the oral cavity, pharynx, and larynx. …”
Publicado 2022
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146898por Moreno, Eva, Matondo, Augustine B., Bongiovanni, Laura, van de Lest, Chris H. A., Molenaar, Martijn R., Toussaint, Mathilda J. M., van Essen, Saskia C., Houweling, Martin, Helms, J. Bernd, Westendorp, Bart, de Bruin, Alain“…Liver‐specific deletion of Pten in mice results in the hyper‐activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid accumulation (steatosis) and formation of hepatocellular carcinomas. However, it is unknown whether polyploidization in this model has an impact on the development of steatosis and the progression towards liver cancer. …”
Publicado 2022
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146899“…An HPV-DNA test, which provides higher protection against invasive cervical carcinomas, is replacing the long-standing Pap smear as the primary method of cervical cancer screening. …”
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146900por de Alcântara, Angélica Leite, Pastana, Lucas Favacho, Gellen, Laura Patrícia Albarello, Vieira, Giovana Miranda, Dobbin, Elizabeth Ayres Fragoso, Silva, Thays Amâncio, Pereira, Esdras Edgar Batista, Rodrigues, Juliana Carla Gomes, Guerreiro, João Farias, Fernandes, Marianne Rodrigues, de Assumpção, Paulo Pimentel, Cohen-Paes, Amanda de Nazaré, Santos, Sidney Emanuel Batista Dos, dos Santos, Ney Pereira Carneiro“…The mucin (MUC) family includes several genes aberrantly expressed in multiple carcinomas and mediates diverse pathways essentials for oncogenesis, in both solid and hematological malignancies. …”
Publicado 2022
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