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148401“…Emerging evidence has suggested that circular RNAs (circRNAs) are important regulators in multiple biological activities of carcinomas. Nevertheless, the role of circRNAs derived from forkhead box M1 (FOXM1), a well-accepted modulator of OS progression, has not been discussed in OS. …”
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148402por Peixoto, Ana, Cirnes, Luís, Carvalho, Ana Luísa, Andrade, Maria João, Brito, Maria José, Borralho, Paula, Borralho, Pedro M., Carneiro, Ana Sofia, Castro, Lisandra, Correia, Lurdes, Dionísio, Maria Rita, Faria, Carlos, Figueiredo, Paulo, Gomes, Ana, Paixão, Joana, Pinheiro, Manuela, Prazeres, Hugo, Ribeiro, Joana, Salgueiro, Natália, Schmitt, Fernando C., Silva, Fátima, Silvestre, Ana Rita, Sousa, Ana Carla, Almeida-Tavares, Joana, Teixeira, Manuel R., André, Saudade, Machado, José Carlos“…Background: Around 40% of ER+/HER2-breast carcinomas (BC) present mutations in the PIK3CA gene. …”
Publicado 2023
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148403por De Gregorio, Cristian, Catalán, Evelyng, Garrido, Gabriel, Morandé, Pilar, Bennett, Jimena Castillo, Muñoz, Catalina, Cofré, Glenda, Huang, Ya-Lin, Cuadra, Bárbara, Murgas, Paola, Calvo, Margarita, Altermatt, Fernando, Yubero, María Joao, Palisson, Francis, South, Andrew P., Ezquer, Marcelo, Fuentes, Ignacia“…RDEB patients suffer from skin fragility starting with blister formation and evolving into chronic wounds, inflammation and skin fibrosis, with a high risk of developing aggressive skin carcinomas. Restricted therapeutic options are limited by the lack of in vitro models of defective wound healing in RDEB patients. …”
Publicado 2023
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148404por Eppich, Simon, Kuhn, Christina, Schmoeckel, Elisa, Mayr, Doris, Mahner, Sven, Jeschke, Udo, Gallwas, Julia, Heidegger, Helene Hildegard“…In a former paper, our research group was able to describe MSX1 as a positive prognosticator in endometrial carcinomas. The aim of this study was to examine the MSX1 expression in healthy endometrial tissue throughout the different phases to gain more insight on the mechanics of MSX-regulation in the female reproductive system. …”
Publicado 2023
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148405“…METHODS: Between May 2012 and September 2018, 28 patients of bladder urothelial carcinomas (clinical stage T2–4aN0M0) who underwent RARC with intracorporeal urinary diversion (IUD) were included. …”
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148406por Sun, Wei-Zen, Lin, Han-Wei, Chen, Wan-Yu, Chien, Chung-Liang, Lai, Yen-Ling, Chen, Jung, Chen, Yu-Li, Cheng, Wen-Fang“…CONCLUSIONS: Dual blockade of BTLA on B cells and PD-1 on cytotoxic T cells may have clinical potential for enhancing the efficacy of PTX in the treatment of tumors with intraperitoneal spread, including epithelial ovarian carcinomas.…”
Publicado 2023
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148407por Sproll, Karl Christoph, Hermes, Iryna, Felder, Gerd, Stoecklein, Nikolas H., Seidl, Maximilian, Kaiser, Peter, Kaisers, Wolfgang“…CONCLUSION: Our LN mapping and meticulous 1:1 node-by-node comparison reveals the usefulness of US for detecting metastatic involvement of neck LNs in head and neck carcinomas as compared to histopathology. The predictive ability for small tumor deposits less than 8 mm in size remains weak and urgently needs improvement. …”
Publicado 2023
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148408“…(A x CBA(T6)F1 mice bearing F1 mammary carcinomas for 9 days were injected i.v. with A strain spleen cells. …”
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148409por Paz-Ares, L., Kunka, R., DeMaria, D., Cassidy, J., Alden, M., Beranek, P., Kaye, S., Littlefield, D., Reilly, D., Depee, S., Wissel, P., Twelves, C., O'Dwyer, P.“…Three partial and two minor responses lasting 8-34+ weeks were noted in patients with ovarian, colon and breast carcinomas and hepatoma. Mean steady-state concentrations of Gl147211 increased with dose over a range of 0.25-1.24 ng ml(-1). …”
Publicado 1998
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148410por Herring, C J, Deans, B, Elder, R H, Rafferty, J A, MacKinnon, J, Barzilay, G, Hickson, I D, Hendry, J H, Margison, GP“…This contrasts with the correlation we have found between HAP1 levels and radiosensitivity in cervix carcinomas (Herring et al (1998) Br J Cancer 78: 1128–1133), indicating that HAP1 levels in this case assume a critical survival role and hence that established cell lines might not be a suitable model for such studies. © 1999 Cancer Research Campaign…”
Publicado 1999
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148411por Vonlanthen, S, Heighway, J, Altermatt, H J, Gugger, M, Kappeler, A, Borner, M M, Lohuizen, M van, Betticher, D C“…Tumours (48 resectable NSCLC (32 squamous, 9 adeno-, 2 large cell, 4 undifferentiated carcinomas and 1 carcinoid); stage I, 29, II, 7, III, 12; T1, 18, T2, 30; differentiation: G1 12, G2 19, G3 17) were studied by immunohistochemistry for protein expression and by comparative multiplex PCR for gene amplification analysis. …”
Publicado 2001
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148412por Alonso-Alconada, Lorena, Muinelo-Romay, Laura, Madissoo, Kadri, Diaz-Lopez, Antonio, Krakstad, Camilla, Trovik, Jone, Wik, Elisabeth, Hapangama, Dharani, Coenegrachts, Lieve, Cano, Amparo, Gil-Moreno, Antonio, Chiva, Luis, Cueva, Juan, Vieito, Maria, Ortega, Eugenia, Mariscal, Javier, Colas, Eva, Castellvi, Josep, Cusido, Maite, Dolcet, Xavier, Nijman, Hans W, Bosse, Tjalling, Green, John A, Romano, Andrea, Reventos, Jaume, Lopez-Lopez, Rafael, Salvesen, Helga B, Amant, Frederic, Matias-Guiu, Xavier, Moreno-Bueno, Gema, Abal, Miguel“…METHODS: CTC isolation was carried out in peripheral blood samples from 34 patients, ranging from Grade 3 Stage IB to Stage IV carcinomas and recurrences, and 27 healthy controls using two methodologies. …”
Publicado 2014
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148413por Cizeron-Clairac, Geraldine, Lallemand, François, Vacher, Sophie, Lidereau, Rosette, Bieche, Ivan, Callens, Celine“…Aim of this study is to identify miRNAs that are differentially expressed in estrogen receptor positive (ER(+)) and negative (ER(−)) breast primary tumors to better understand the molecular basis for the phenotypic differences between these two sub-types of carcinomas and to find potential clinically relevant miRNAs. …”
Publicado 2015
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148414por Klöss, Stephan, Chambron, Nicole, Gardlowski, Tanja, Weil, Sandra, Koch, Joachim, Esser, Ruth, Pogge von Strandmann, Elke, Morgan, Michael A., Arseniev, Lubomir, Seitz, Oliver, Köhl, Ulrike“…Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β(1)), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for therapeutic intervention. …”
Publicado 2015
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148415por Gray, Michael J., Gong, Jian, Hatch, Michaela M. S., Nguyen, Van, Hughes, Christopher C. W., Hutchins, Jeff T., Freimark, Bruce D.“…BACKGROUND: The purpose of this study was to investigate the potential of antibody-directed immunotherapy targeting the aminophospholipid phosphatidylserine, which promotes immunosuppression when exposed in the tumor microenvironment, alone and in combination with antibody treatment towards the T-cell checkpoint inhibitor PD-1 in breast carcinomas, including triple-negative breast cancers. …”
Publicado 2016
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148416por Linxweiler, Maximilian, Bochen, Florian, Schick, Bernhard, Wemmert, Silke, Al Kadah, Basel, Greiner, Markus, Hasenfus, Andrea, Bohle, Rainer-Maria, Juhasz-Böss, Ingolf, Solomayer, Erich-Franz, Takacs, Zoltan Ferenc“…RESULTS: FISH analyses of the swabbed cells showed a rising number of SEC62 gains and amplifications correlating to the grade of dysplasia with the highest incidence in high grade squamous intraepithelial lesions and squamous cell carcinomas. When analyzing the expression level of Sec62 and vimentin, we found a gradually increasing expression level of both proteins according to the severity of the dysplasia. …”
Publicado 2016
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148417por Foy, Jean-Philippe, Bazire, Louis, Ortiz-Cuaran, Sandra, Deneuve, Sophie, Kielbassa, Janice, Thomas, Emilie, Viari, Alain, Puisieux, Alain, Goudot, Patrick, Bertolus, Chloé, Foray, Nicolas, Kirova, Youlia, Verrelle, Pierre, Saintigny, Pierre“…BACKGROUND: Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. …”
Publicado 2017
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148418por Tod, Jo, Hanley, Christopher J, Morgan, Mark R, Rucka, Marta, Mellows, Toby, Lopez, Maria‐Antoinette, Kiely, Philip, Moutasim, Karwan A, Frampton, Steven J, Sabnis, Durgagauri, Fine, David R, Johnson, Colin, Marshall, John F, Scita, Giorgio, Jenei, Veronika, Thomas, Gareth J“…The integrin αvβ6 is up‐regulated in numerous carcinomas, where expression commonly correlates with poor prognosis. αvβ6 promotes tumour invasion, partly through regulation of proteases and cell migration, and is also the principal mechanism by which epithelial cells activate TGF‐β1; this latter function complicates therapeutic targeting of αvβ6, since TGF‐β1 has both tumour‐promoting and ‐suppressive effects. …”
Publicado 2017
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148419por Gong, Xianling, Chen, Zhihong, Han, Qinrui, Chen, Chunhui, Jing, Linlin, Liu, Yawei, Zhao, Liang, Yao, Xueqing, Sun, Xuegang“…RESULTS: Sanguinarine decreased the tumor size in a dose-dependent manner in orthotopical colorectal carcinomas through intrinsic apoptosis pathway in BALB/c-nu mice. …”
Publicado 2018
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148420por Gunaratne, Preethi H., Pan, Yinghong, Rao, Abhi K., Lin, Chunru, Hernandez‐Herrera, Anadulce, Liang, Ke, Rait, Antonina S., Venkatanarayan, Avinashnarayan, Benham, Ashley L., Rubab, Farwah, Kim, Sang Soo, Rajapakshe, Kimal, Chan, Clara K., Mangala, Lingegowda S., Lopez‐Berestein, Gabriel, Sood, Anil K., Rowat, Amy C., Coarfa, Cristian, Pirollo, Kathleen F., Flores, Elsa R., Chang, Esther H.“…BACKGROUND: Over 96% of high‐grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. …”
Publicado 2019
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