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  1. 7281
    “…However, the genomic islands of discrepancy observed between butyrogenic L. plantarum strains (S2T10D, S11T3E) and the non-butyrogenic strain O2T60C do not encompass genes of FASII, but several cassettes of genes related to sugar metabolism, bacteriocins, prophages and surface proteins. …”
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    Genomic assessment in Lactobacillus plantarum links the butyrogenic pathway with glutamine metabolism
  2. 7282
    “…Saccharomyces cerevisiae and its closely related yeasts undergo mating type switching by replacing DNA sequences at the active mating type locus (MAT) with one of two silent mating type cassettes. Recently, a novel mode of mating type switching was reported in methylotrophic yeast, including Ogataea polymorpha, which utilizes chromosomal recombination between inverted-repeat sequences flanking two MAT loci. …”
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    Regulation of mating type switching by the mating type genes and RME1 in Ogataea polymorpha
  3. 7283
    “…The present study supplies several experimentally tested guidelines for crRNA design, as well as plasmids for FnCpf1 expression and easy construction of crRNA expression cassettes in S. cerevisiae. FnCpf1 proves to be a powerful addition to S. cerevisiae CRISPR toolbox.…”
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    FnCpf1: a novel and efficient genome editing tool for Saccharomyces cerevisiae
  4. 7284
    “…Our strategy involves silencing the myotoxic gene DUX4 using adeno-associated viral vectors to deliver targeted microRNA expression cassettes (miDUX4s). We previously demonstrated proof of concept for this approach in mice, and we are now taking additional steps here to assess safety issues related to miDUX4 overexpression and sequence-specific off-target silencing. …”
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    Pre-clinical Safety and Off-Target Studies to Support Translation of AAV-Mediated RNAi Therapy for FSHD
  5. 7285
    “…The studied Baltic Sea strains share similar sets of CRISPR-Cas cassettes and a higher number of insertion sequence (IS) elements compared to Nodularia spumigena CENA596 isolated from a shrimp production pond in Brazil. …”
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    Comparative Genomics of the Baltic Sea Toxic Cyanobacteria Nodularia spumigena UHCC 0039 and Its Response to Varying Salinity
  6. 7286
    “…The stable transfection of bicistronic expression cassettes with re-initiation of the translation mechanism enabled the generation of LentiPro26 packaging populations supporting high titers. …”
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    LentiPro26: novel stable cell lines for constitutive lentiviral vector production
  7. 7287
    “…In this system, a plasmid bearing Cas9 and gRNA expression cassettes will induce a double-strand break (DSB) inside a biosynthesis gene such as Met15 or Lys2. …”
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    A set of novel CRISPR-based integrative vectors for Saccharomyces cerevisiae
  8. 7288
    “…Here we describe the design and characterization of recombinant adeno-associated viral (AAV) vectors packaging transgene cassettes containing intronic sequences that promote backsplicing to generate circularized RNA transcripts. …”
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    Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo
  9. 7289
    “…Studies on the genetic basis of antimicrobial resistance in these bacteria identified SCCmec cassettes, various transposons and plasmids of different sizes that harbor antimicrobial resistance genes. …”
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    Small Antimicrobial Resistance Plasmids in Livestock-Associated Methicillin-Resistant Staphylococcus aureus CC398
  10. 7290
    “…TEAZ can deliver DNA constructs with promoter elements of interest to drive fluorophores, oncogenes or CRISPR-Cas9-based mutagenic cassettes in specific cell types. Using TEAZ, we created a highly aggressive melanoma model via Cas9-mediated inactivation of Rb1 in the context of BRAF(V600E) in spatially constrained melanocytes. …”
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    Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)
  11. 7291
    “…Different arrangements of gene cassettes were detected in the variable region of class 1 integron: dfrA16, aadA23 and dfrA1-aadA1. …”
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    Antimicrobial Resistance in Class 1 Integron-Positive Shiga Toxin-Producing Escherichia coli Isolated from Cattle, Pigs, Food and Farm Environment
  12. 7292
    “…Integrons are associated with a variety of gene cassettes, which confer resistance to multiple classes of antibiotics. …”
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    Prevalence of class 1, 2 and 3 integrons among multidrug-resistant Pseudomonas aeruginosa in Yazd, Iran
  13. 7293
    “…These results were further confirmed by the transient expression studies with promoter-reporter cassettes carrying TGAC and TGAC-ACGT variant motifs with spacer lengths of 5 and 10.…”
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    Genome wide analysis of W-box element in Arabidopsis thaliana reveals TGAC motif with genes down regulated by heat and salinity
  14. 7294
    “…To answer this question, we used CRISPR/Cas9 technology to introduce I-SceI sites, or repair pathway reporter cassettes, at defined locations within gene-rich (high H4K16ac/euchromatin) and gene-poor (low H4K16ac/heterochromatin) regions. …”
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    Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
  15. 7295
    “…As proof of concept, a 2.5‐kb DNA fragment comprising aroG (fbr) pheA (fbr) expressing cassettes was integrated into the genome of C. glutamicum, with an efficiency of 20% out of the theoretical 50%. …”
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    An update of the suicide plasmid‐mediated genome editing system in Corynebacterium glutamicum
  16. 7296
    “…Our findings show robust protection from silencing of transgene cassettes mediated by the ubiquitous chromatin-opening element (UCOE) derived from the HNRPA2B1-CBX3 locus. …”
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    Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)
  17. 7297
    “…Subsequently, we developed a reliable and consistent pipeline to precisely introduce cassettes of several kb size into the genome of primary murine B cells also using CRISPR-Cas9 induced HDR. …”
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    Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells
  18. 7298
    “…Integration of the expression constructs into the native genomic locus and removal of resistance cassettes were required to obtain a wild‐type‐like expression pattern. …”
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    Conditional gene expression reveals stage‐specific functions of the unfolded protein response in the Ustilago maydis–maize pathosystem
  19. 7299
    “…In this paper, eight founder lines of transgenic mice were generated by co-microinjection of the two cassettes encoding the heavy- and light-chains of a neutralizing anti-HAV antibody, respectively. …”
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    Functional recombinant human anti-HAV antibody expressed in milk of transgenic mice
  20. 7300
    “…CONCLUSIONS: Overall, our tool greatly extends the classification of CRISPR cassettes and, for the first time, predicts missing Cas proteins and association rules between Cas proteins. …”
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    CRISPRcasIdentifier: Machine learning for accurate identification and classification of CRISPR-Cas systems
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