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301“…Of particular interest within organosulfur chemistry is the ease with which the synthetic chemist can effect a wide range of transformations through either bond formation or bond cleavage at sulfur. …”
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302“…Here, some of these uncertainties are highlighted with recent examples from the literature, together with snippets of advice for the medicinal chemist embarking on using X-ray crystal structure information in a drug discovery programme.…”
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303Publicado 2020“…Boydston is the Yamamoto Family Professor of Chemistry at the University of Wisconsin-Madison. As a trained chemist he worked on catalysts for the synthesis of polymers during his postdoc time and started his independent career as an assistant professor of Chemistry in 2010 at the University of Washington. …”
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304por Astolfi, Maria Luisa, Conti, Marcelo Enrique, Marconi, Elisabetta, Massimi, Lorenzo, Canepari, Silvia“…The present study highlights the possible drawbacks that may be encountered during the elemental analysis of these biological matrices and aims to be a valuable aid for the analytical chemist. Total elemental concentrations, determined in commercially available beehive products, are presented.…”
Publicado 2020
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305por Campora, Marta, Francesconi, Valeria, Schenone, Silvia, Tasso, Bruno, Tonelli, Michele“…AD imposes neuronal death by the intricate interplay of different neurochemical factors, which continue to inspire the medicinal chemist as molecular targets for the development of new agents for the treatment of AD with diverse mechanisms of action, but also depict a more complex AD scenario. …”
Publicado 2021
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306“…They were first formulated by a chemist and used experimentally on a 2-year-old girl with PKU and their nutritional formulations and design have improved over time. …”
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307por Tomassi, Stefano, Romanelli, Annalisa, Zwergel, Clemens, Valente, Sergio, Mai, Antonello“…In this Perspective, we aim to summarize the latest findings regarding the development and the biological activity of these emerging classes of PRC2 modulators from a medicinal chemist’s viewpoint.…”
Publicado 2021
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308por Ribaudo, Giovanni, Ongaro, Alberto, Oselladore, Erika, Memo, Maurizio, Gianoncelli, Alessandra“…The combination of ESI-MS and in silico techniques in a hybrid high-throughput-screening workflow represents a valuable tool for the medicinal chemist, providing data on the quantitative and structural aspects of ligand–GQ interactions.…”
Publicado 2021
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309“…Integrating concepts from both sets of literature – particularly national sociotechnical imaginaries and socio-spatial positionality – this article explores how Dr Chaim Weizmann, a prominent chemist and a Zionist leader, attempted to construct and mobilize a ‘scientific diaspora’. …”
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310“…The experienced synthetic chemist will probe many of these variables during reaction development and optimization, which will routinely involve investigation of reaction temperature, solvent, stoichiometry, concentration, time, choice of catalyst, addition sequence or quenching conditions just to name some commonly addressed variables. …”
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311por Tilden, James A. R., Lubben, Anneke T., Reeksting, Shaun B., Kociok‐Köhn, Gabriele, Frost, Christopher G.“…Selective bioconjugation remains a significant challenge for the synthetic chemist due to the stringent reaction conditions required by biomolecules coupled with their high degree of functionality. …”
Publicado 2022
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312por Gouveia, Micael G., Wesseler, Justus P., Ramaekers, Jobbe, Weder, Christoph, Scholten, Philip B. V., Bruns, Nico“…Considering this complex subject from a polymer chemist's point of view, we highlight key areas that are worthy to explore in order to advance polymersomes to a level at which clinical trials become worthwhile and translation into pharmaceutical and nanomedical applications is realistic.…”
Publicado 2022
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313por Lehrer, Jonah“…You’ll meet a Manhattan bartender who thinks like a chemist, and an autistic surfer who invented an entirely new surfing move. …”
Publicado 2012
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314por Taylor, Connor J., Pomberger, Alexander, Felton, Kobi C., Grainger, Rachel, Barecka, Magda, Chamberlain, Thomas W., Bourne, Richard A., Johnson, Christopher N., Lapkin, Alexei A.“…[Image: see text] From the start of a synthetic chemist’s training, experiments are conducted based on recipes from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist to develop practical skills and some chemical intuition. …”
Publicado 2023
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315“…The individuals’ image of environmental scientists can be generally abstracted as a male with environmental protection knowledge and commitment to environmental protection who does work more like a green chemist, ecology restorer, or plant protector and observes or cleans outdoors, primarily in forest, jungle, and/or by riverside.…”
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316por Kauzlarich, Susan M.“…Zintl phases are named in recognition of Eduard Zintl, a German chemist who first studied a subgroup of intermetallics prepared with electropositive metals combined with main-group metalloids from groups 13–15 in the 1930s. …”
Publicado 2023
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317“…Nature has efficiently adopted phosphorylation for numerous biological key processes, spanning from cell signaling to energy storage and transmission. For the bioorganic chemist the number of possible ways to attach a single phosphate for radioactive labeling is surprisingly small. …”
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318por Smith, Kendall A.“…This review chronicles Pasteur’s remarkable metamorphosis from organic chemist to microbiologist to immunologist, and from basic science to medicine.…”
Publicado 2012
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319“…The use of nutrition in medical practice has a long history dating back to 6000 years. The great Persian chemist, physician, and philosopher, Rhazes (865-925 AD), wrote over 200 books in different branches of science. …”
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320por Singh, Jaswinder, Singh, Narinder, Kumar, Rahat, Bhandari, Vikram, Kaur, Navpreet, Dureja, Sheveta“…MATERIALS AND METHODS: A total of two hundred sixty four patients having a valid prescription from a doctor practicing in allopathic system, visiting 4 different chemist shops in a North Indian city were enrolled in the study. …”
Publicado 2013
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