“…A number of quadruplex-interactive ligands have been developed by synthetic and medicinal chemists over the past decades. However, the great challenge still remains that the method for detecting the specific targeting of these ligands to the G-quadruplex structures in cells is still lacking. …”
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“…This Review will describe the increasing importance of the concepts of biological variation to clinical chemists. The idea of comparison to ‘reference’ is fundamental in measurement. …”
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“…Exploration of novel, three‐dimensional chemical space is of growing interest in the drug discovery community and with this comes the challenge for synthetic chemists to devise new stereoselective methods to introduce chirality in a rapid and efficient manner. …”
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“…The perfect blend of complex and unique architectures and biological activity has made sesquiterpene dimers an attractive and challenging synthetic target, inspiring organic chemists to find new and biomimetic approaches to replicate the efficiency and the selectivity of natural processes under laboratory conditions. …”
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“…We identified the physicochemical properties of efficient catalysts for hydrogenolysis: (1) small Pd/PdO particle size (2) homogeneous distribution of Pd/PdO on the carbon support, and (3) palladium oxidation state are good predictors of catalytic efficiency. Now chemists can identify and predict a catalyst’s efficiency prior to the use of valuable synthetic material and time.…”
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“…Aryl and heteroaryl selenides and tellurides are found to have broad applications in the diverse fields such as medicine, biology, materials science, pharmaceutical etc. and thus their synthesis remains a challenging field for synthetic chemists in last decade. Although a large no of methodologies have been developed based on metal catalyzed C–Se/Te coupling, a large number of researches has been focused on developing metal catalyst free protocols due to their sustainability in recent times. …”
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“…Novel structures and important biological activity have made indole diterpenes one of the focuses of synthetic chemists. Although the discovery, identification, structural diversity, biological activity and especially structure–activity relationship of indole diterpenes have been reported in some papers in recent years, they are absent of a systematic and comprehensive analysis, and there is no elucidation of enzymes related to this kind of natural product. …”
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“…Thus, the MaskGAN model can be used to generate organic reactions and aid chemists in the exploration of novel reactions.…”
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“…In this review, the scope of substrates and reaction mechanisms of various synthetic approaches using imidazole N-oxides as substrates are summarized so that the chemists, researchers, and pharmaceutical industries find its effectiveness in near future for the synthesis of potent, novel, and non-toxic drug molecules.…”
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“…A significant portion of the book deals with discussions of the fundamental and applied problems of important phenomena such as ion association, ion adsorption, ion solvation, electrical double layer, thin colloidal film stability, ion collective dynamics, ion screening, etc. using a level of argumentation that is common and understandable for mathematicians, physicists, chemists, biologists and engineers. The book concludes with chapter on physical properties of fuel-containing materials from the inside of the troubled Chornobyl sarcophagus.…”
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“…Subsequently, it shows how the individual view of metals and alloys by physicists, chemists and metallurgists can be unified. The physical phenomena of metals and alloys covered in this book are: Miscibility Gap between two liquid metals; Phase Equilibrium Diagrams; Phenomenon of Melting. …”
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“…This book should be of interest to theoretical physicists, chemists, applied mathematicians and historians of science, and is accessible to graduate (and advanced undergraduate) students.…”
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“…Appendices with a summary and comparison of techniques and a list of equipment suppliers make this book a rapid reference for materials scientists, analytical chemists, and those working in the biotechnological industry. …”
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“…It remains one of the most popular and cost-effective analysis tools used by chemists, physicists, and materials scientists worldwide. …”
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“…The successful implementations of molecular imaging in man will only be realised by the close co-operation amongst molecular biologists, chemists and the imaging scientists.…”
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“…This revised edition includes updates and additions on hot topics such as molecular spintronics (the role of spin in electron transport) and molecular machines (how electrons can generate molecular motions). Chemists will discover how to understand the relations between electronic structures and properties of molecular entities and assemblies, and to design new molecules and materials. …”
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“…Among the tools available to chemists for drug design of bioactive compounds, the bioisosteric replacement of atoms or groups of atoms is the cornerstone of modern strategies. …”
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“…While synthetic and chemoenzymatic methods have enabled access to homogeneous tool compounds, a central problem, particularly for newer synthetic chemists, is the matter of problem selection. This outlook aims to provide an entry level overview of fundamental principles in carbohydrate chemistry with an eye toward enabling solutions to frontier challenges.…”
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“…The biological profiles of heteroatom steroids are of considerable interest to chemists, biologists, pharmacologists, and the pharmaceutical industry. …”
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