“…This study exemplifies how organic chemists can exploit state-of-the-art technologies to markedly increase throughput and confidence in the preparation of drug-like molecules.…”
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“…The predictions are useful to environmental chemists that look for metabolic intermediates, for regulators looking for potential toxic products, for microbiologists seeking to understand microbial biodegradation, and others with a wide-range of interests.…”
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“…Various resources are now available that can be of use to glycobiologists, but also to chemists who work on the synthesis or analysis of carbohydrates. …”
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“…In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. …”
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“…The on-surface formation of organometallic monomers or oligomers, especially in supramolecular network, attracts an extensive interest for chemists and material scientist. In this work, we have investigated metal coordination between zinc (II) phthalocyanine (ZnPc) and 1, 3-di (4-pyridyl) propane (dipy-pra) in the 2, 6, 11-tricarboxydecyloxy-3, 7, 10-triundecyloxy triphenylene (asym-TTT) supramolecular template by means of scanning tunneling microscopy (STM) on highly oriented pyrolytic graphite (HOPG) substrate under ambient conditions. …”
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“…The concept exemplified here for serotonin receptor ligands can likely be more broadly applied to other target classes, thus representing a useful guide for medicinal chemists designing novel ligands.…”
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“…Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. …”
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“…While this molecule has attracted significant interests from the synthetic community, an efficient synthetic strategy is still the goal of many synthetic chemists. Here we report the asymmetric total synthesis of (+)-gelsemine, including a highly diastereoselective and enantioselective organocatalytic Diels–Alder reaction, an efficient intramolecular trans-annular aldol condensation furnishing the prolidine ring and establishing the configuration of the C20 quaternary carbon stereochemical centre. …”
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“…In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra with asymmetric faces. …”
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“…In the 1950s clinical chemists combined the Henderson–Hasselbalch equation and the Bronsted–Lowry definition of an acid to produce the current bicarbonate ion-centred approach to metabolic acid–base disorders. …”
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“…Increased cooperation between chemists and biochemists, immunologists and physicists, has allowed us to think outside the box, and we are slowly starting to understand the interactions that nanoparticles undergo under more realistic situations. …”
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“…For decades, the planarity of the amide functional group has garnered sustained interest in organic chemistry, enticing chemists to deform its usually characteristic high-fidelity plane. …”
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“…They have become a reliable tool for the α- and β-activation of carbonyl compounds, via HOMO, SOMO or LUMO activation pathways. Recently, chemists have turned their attention to the development of novel organocatalytic strategies for remote functionalisation, targeting stereocentres even more distant from the catalyst-activation site, through dienamine, trienamine, and vinylogous iminium ion pathways (γ-, ε- and δ-positions, respectively). …”
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“…This observation is hitherto unknown, tested for a variety of salicylaldehyde, amine and acetylene, established as a general protocol, and is believed to be of interest for synthetic chemists from green chemistry.…”
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“…Recent development of nanoplasmonics has stimulated chemists to utilize plasmonic nanomaterials for efficient and distinctive photochemical applications, and physicists to boldly go inside the “wet” chemistry world. …”
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“…Enzyme‐mediated oxidation is of particular interest to synthetic organic chemists. However, the implementation of such systems demands knowledge of enzyme kinetics. …”
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“…The unique structures and interesting biological profiles of these two meroterpenoids have attracted considerable attention from synthetic chemists. Herein we summarize the synthetic efforts with respect to (+)-liphagal and (+)-frondosin B during the past two decades.…”
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“…Besides its biological importance, its structural features have also gathered tremendous interest from both medicinal and synthetic chemists. By a medicinal chemistry and total synthesis approach, numerous analogs from BFA have been developed to improve its inferior bioavailability and its antiproliferative ability. …”
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“…Strategies for the facile fabrication of nanoscale materials and devices represent an increasingly important challenge for chemists. Here, we report a simple, one-pot procedure for the formation of perfluorocarbon emulsions with defined functionalization. …”
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“…To develop catalytic systems that are fast, selective and controlled is a persistent effort of chemists. In this contribution, we report a binary urea/alkoxide catalytic system that could catalyze ROP of rac-LA in a fast (over 90% conversion within 1–2 min), stereoselective (P(i) up to 0.93) and controlled manner, indicated by narrow MW distributions, linear relationship between the monomer conversions and M(n)s, end-group fidelity, and chain extension experiments. …”
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