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  1. 1121
    “…The longer acenes with more than six linearly fused six‐membered rings are still fascinating chemists and physicists because of their unique photophysical properties and their high potential for organic electronics applications. …”
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    Benzo‐Fused Perylene Oligomers with up to 13 Linearly Annulated Rings
  2. 1122
    “…This comprehensive review will assist medicinal chemists to understand new strategies that can result in the development of compounds with potential therapeutic efficacy.…”
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    Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery
  3. 1123
    “…The α-ketoamide motif is found in many natural products, and it has been widely exploited by medicinal chemists to develop compounds tailored to a vast range of biological targets, thus presenting clinical potential for a plethora of pathological conditions. …”
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    The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities
  4. 1124
    “…Aromaticity is a central concept in chemistry, pervading areas from biochemistry to materials science. Recently, chemists also started to exploit intricate phenomena such as the interplay of local and global (anti)aromaticity or aromaticity in non‐planar systems and three dimensions. …”
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    Visualisation of Chemical Shielding Tensors (VIST) to Elucidate Aromaticity and Antiaromaticity
  5. 1125
    “…TZD has been shown to exhibit biological action towards a vast range of targets interesting to medicinal chemists. In this review, we attempt to provide insight into both the historical conventional and the use of novel methodologies to synthesise the TZD core framework. …”
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    Thiazolidinediones: An In–Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus
  6. 1126
    “…Designing compounds for the selective molecular recognition of carbohydrates is a challenging task for supramolecular chemists. Macrocyclic compounds that incorporate isophtalamide or bisurea spacers linking two aromatic moieties have proven effective for the selective recognition of all‐equatorial carbohydrates. …”
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    An Octa‐Urea [Pd(2)L(4)](4+) Cage that Selectively Binds to n‐octyl‐α‐D‐Mannoside
  7. 1127
    “…Sulfonium salts bearing a positively charged sulfur atom with three organic substituents have intrigued chemists for more than a century for their unusual structures and high chemical reactivity. …”
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    Generation of non-stabilized alkyl radicals from thianthrenium salts for C–B and C–C bond formation
  8. 1128
    “…The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of compounds, opening up the opportunity for selective C–H functionalisation. …”
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    Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
  9. 1129
    “…The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications.…”
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    Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects
  10. 1130
    “…To bridge this gap, microbiome scientists should engage analytical chemists to best understand the underlying chemical principles of the data. …”
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    Bridging the Gap between Analytical and Microbial Sciences in Microbiome Research
  11. 1131
    “…The enantioselective construction of C–CF(2)R (R: alkyl or fluoroalkyl) bonds has attracted the attention of synthetic chemists because of the importance of chiral fluorinated compounds in life and materials sciences. …”
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    Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
  12. 1132
    “…The strong dependence on orientation and solvent together with the relatively small interaction energies have made evaluation and rationalization a challenge for experimental and theoretical chemists. We have used a supramolecular cage formed by two tris(pyridylmethyl)amines units to build chemical Double Mutant Cycles (DMC) for the experimental measurement of the free energies of π‐stacking interactions. …”
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    Dissection of the Polar and Non‐Polar Contributions to Aromatic Stacking Interactions in Solution
  13. 1133
    “…We conducted a user evaluation with domain experts, including epidemiologists, biochemists, medicinal chemists, and medicine students. In general, most users were satisfied with the relevance and speed of the search results. …”
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    A term-based and citation network-based search system for COVID-19
  14. 1134
    “…Consequently, developing new synthetic methods for the construction of nitrogenous molecules receives great attention from organic chemists. The Mannich reaction is a very basic and very useful platform for the development of several such nitrogen-containing molecules. …”
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    Recent advances and prospects in the Zn-catalysed Mannich reaction
  15. 1135
    “…These alkaloids have attracted extensive attention from medicinal chemists and pharmacologists owing to their diverse arrays of chemical structures and biological activities, and a series of 1,3-oxazole derivatives has been developed into therapeutic agents (e.g., almoxatone, befloxatone, cabotegravir, delpazolid, fenpipalone, haloxazolam, inavolisib). …”
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    An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms
  16. 1136
    “…This review will mark the impact as the valuable, comprehensive and pioneered work along with the library of synthetic strategies for the organic and medicinal chemists for further refinement of 1,2,4-oxadiazole as anti-infective agents. …”
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    A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents
  17. 1137
    por Qin, Da, He, Zhen, Li, Peng, Zhang, Shutian
    Publicado 2022
    “…Biomineralization is a typical interdisciplinary subject attracting biologists, chemists, and geologists to figure out its potential mechanism. …”
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    Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization
  18. 1138
    “…Especially, biologically significant natural molecules and their structural analogues have inspired chemists and made a major contribution to the development of advanced smart materials. …”
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    Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications
  19. 1139
    “…Nowadays synthesis of coumarins and their derivatives has attracted considerable attention from organic and medicinal chemists for many years as a large number of natural products contain this heterocyclic nucleus. …”
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    A review on convenient synthesis of substituted coumarins using reuseable solid acid catalysts
  20. 1140
    “…Organic heterostructure nanowires, such as multiblock, core/shell, branch-like and related compounds, have attracted chemists’ extensive attention because of their novel physicochemical properties. …”
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    Lattice-mismatch-free growth of organic heterostructure nanowires from cocrystals to alloys
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