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1321“…Tables providing comprehensive directories of fulvene cycloaddition chemistry are provided, including fulvene intramolecular and intermolecular cycloadditions complete with reactant partners and their resulting cyclic adducts, which provide a useful reference source for synthetic chemists working with fulvenes and complex polycyclic scaffolds.…”
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1322“…The project aims to support the chemists in their efforts to re-use chemistry research data by providing them missing tools for an automated assembly of reaction data.…”
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1323“…The organic multiredox systems are further classified into multielectron acceptors, multielectron donors and ambipolar molecules. Synthetic chemists have integrated different electron donating and electron withdrawing groups to realize these complex molecular systems. …”
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1324“…The Soai reaction has profoundly impacted chemists’ perspective of chiral symmetry breaking, absolute asymmetric synthesis and its role in the origin of biological homochirality. …”
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1325“…Marine sponges continue to attract wide attention from marine natural product chemists and pharmacologists alike due to their remarkable diversity of bioactive compounds. …”
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1326“…With the advent of structural biology in the drug discovery process, medicinal chemists gained the opportunity to use detailed structural information in order to progress screening hits into leads or drug candidates. …”
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1327por Feng, Bin, Xiang, Li, McCabe, Karl N., Maron, Laurent, Leng, Xuebing, Chen, Yaofeng“…Expanding the ranges of M and E represents grand challenges for synthetic chemists and will bring new horizons for the chemistry. …”
Publicado 2020
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1328“…However, in contrast to conventional 1D- and 3D-networked macromolecules, the synthesis of such 2D networks provides challenges for polymer chemists because of the nature of the networking polymerisation reaction, which occurs in a spatially random fashion when conventional solution-phase synthesis is performed. …”
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1329“…They have attracted significant attention from organic and medicinal chemists due to their potent biological activities and the numerous possibilities for structural diversification. …”
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1330por Platzer, Gerald, Mayer, Moriz, Beier, Andreas, Brüschweiler, Sven, Fuchs, Julian E., Engelhardt, Harald, Geist, Leonhard, Bader, Gerd, Schörghuber, Julia, Lichtenecker, Roman, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B., Konrat, Robert“…PI by NMR changes the paradigm by which chemists can optimize the potency of drug candidates: direct determination of individual π interactions rather than averaged measures of all interactions.…”
Publicado 2020
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1331“…Predicting the activities and properties of materials via in silico methods has been shown to be a cost- and time-effective way of aiding chemists in synthesizing materials with desired properties. …”
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1332por Georgiadis, Dimitris, Ziotopoulou, Angeliki, Kaloumenou, Eleni, Lelis, Angelos, Papasava, Antonia“…This review aims to summarize efforts of medicinal chemists toward the design and development of IRAP inhibitors, with special emphasis to factors affecting inhibitor selectivity.…”
Publicado 2020
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1333por Guse, Andreas H.“…For 25 years, Professor Barry Potter has been one of the major medicinal chemists in this topical area, designing and contributing numerous analogues to develop structure–activity relationships (SAR) as a basis for tool development in biochemistry and cell biology and for lead development in proof-of-concept studies in disease models. …”
Publicado 2020
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1334por Sabourian, Parinaz, Yazdani, Ghazaleh, Ashraf, Seyed Sajad, Frounchi, Masoud, Mashayekhan, Shohreh, Kiani, Sahar, Kakkar, Ashok“…Understanding nanoparticle–cell interactions plays a key role in therapeutic interventions, and it continues to be a topic of great interest to both chemists and biologists. The mechanistic evaluation of cellular uptake is quite complex and is continuously being aided by the design of nanocarriers with desired physico-chemical properties. …”
Publicado 2020
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1335por Kostyuk, Alexander I., Panova, Anastasiya S., Kokova, Aleksandra D., Kotova, Daria A., Maltsev, Dmitry I., Podgorny, Oleg V., Belousov, Vsevolod V., Bilan, Dmitry S.“…We hope that this work reflects the amazing power of this technology and can serve as a useful guide for biologists and chemists who work in the field of redox processes.…”
Publicado 2020
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1336por Marques, Ana C., Mocanu, Alexandra, Tomić, Nataša Z., Balos, Sebastian, Stammen, Elisabeth, Lundevall, Asa, Abrahami, Shoshan T., Günther, Roman, de Kok, John M. M., Teixeira de Freitas, Sofia“…This paper is mainly addressed to chemists, materials scientists, materials engineers, and decision-makers.…”
Publicado 2020
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1337por Lipin, Raju, Dhanabalan, Anantha Krishnan, Gunasekaran, Krishnasamy, Solomon, Rajadurai Vijay“…Overall, the present work proves to offers new insights and guidelines for synthetic chemists to develop new drugs using piperazine substituted Favipiravir in the treatment of Nipah virus. …”
Publicado 2021
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1338“…[Image: see text] Since the definition of the “12 Principles of Green Chemistry” more than 20 years ago, chemists have become increasingly mindful of the need to conserve natural resources and protect the environment through the judicious choice of synthetic routes and materials. …”
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1339por Viana, Iara Maíra de Oliveira, Roussel, Sabrina, Defrêne, Joan, Lima, Eliana Martins, Barabé, Frédéric, Bertrand, Nicolas“…To rationally design therapeutic and vaccines, chemists, materials scientists, and drug delivery experts need to better understand how nanotechnologies interact with the immune system. …”
Publicado 2021
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1340por Schwaller, Philippe, Hoover, Benjamin, Reymond, Jean-Louis, Strobelt, Hendrik, Laino, Teodoro“…During the last few hundred years, chemists compiled the language of chemical synthesis inferring a series of “reaction rules” from knowing how atoms rearrange during a chemical transformation, a process called atom-mapping. …”
Publicado 2021
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