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1401por Avdeef, AlexEnlace del recurso
Publicado 2020
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1402por Ono, Asami, Matsumura, Naoya, Kimoto, Takahiro, Akiyama, Yoshiyuki, Funaki, Satoko, Tamura, Naomi, Hayashi, Shun, Kojima, Yukiko, Fushimi, Masahiro, Sudaki, Hiroshi, Aihara, Risa, Haruna, Yuka, Jiko, Maiko, Iwasaki, Masaru, Fujita, Takuya, Sugano, KiyohikoEnlace del recurso
Publicado 2019
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1403
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1404por Newman, David J.Enlace del recurso
Publicado 2022
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1406
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1407“…The Ugi reaction, one of the most common multicomponent reactions, has recently fascinated chemists with the high diversity brought by its four- or three-component-based isonitrile. …”
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1408Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review“…Owing to the array of information available and highlighted herein on the medicinal potential of quinoline and its functionalized derivatives, a new window of opportunity may be opened to medicinal chemists to access more biomolecular quinolines for future drug development.…”
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1410por Bricotte, Léo, Chougrani, Kamel, Alard, Valérie, Ladmiral, Vincent, Caillol, Sylvain“…This review focuses on the plurality of reactivities of DHA to help chemists interested in bio-based building blocks see the potential of DHA for this application. …”
Publicado 2023
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1411por Salerno, Silvia, Barresi, Elisabetta, Baglini, Emma, Poggetti, Valeria, Da Settimo, Federico, Taliani, Sabrina“…The final goal is to pave the way for medicinal chemists in the future design and development of novel effective indole-based anti-GBM agents.…”
Publicado 2023
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1412“…Interesting new features of chlorin-e(6) chemistry (including the intramolecular formation of an anhydride (24)) are reported, allowing chemists to regioselectively conjugate amino acids to each available carboxylic acid on positions 13(1) (formic), 15(2) (acetic), and 17(3) (propionic) of chlorin e(6) (14). …”
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1413“…Previously, machine learning approaches employing natural language processing techniques achieved promising results in this task by first representing reactant molecules as strings and subsequently predicting reactant molecules using text generation or machine translation models. Chemists cannot readily derive useful insights from traditional approaches that rely largely on atom-level decoding in the string representations, because human experts tend to interpret reactions by analyzing substructures that comprise a molecule. …”
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1414por Guo, Shu-Min, Huh, Soohee, Coehlo, Max, Shen, Li, Pieters, Grégory, Baudoin, Olivier“…The three-dimensional structure of carbohelicenes has fascinated generations of molecular chemists and has been exploited in a wide range of applications. …”
Publicado 2023
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1415por Luo, Fuying, Liu, Le, Wu, Han, Xu, Ling, Rao, Yutao, Zhou, Mingbo, Osuka, Atsuhiro, Song, Jianxin“…As isomers of the regular porphyrins, N-confused porphyrins have attracted extensive attention of chemists because of their unique chemical structures, chemical reactivities, and physical properties, which result in their promising applications in the fields of catalytic chemistry, biochemistry and material science. …”
Publicado 2023
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1416por Zhou, Yu, Zhang, Xinyu, Sheng, Guan, Wang, Shengda, Chen, Muqing, Zhuang, Guilin, Zhu, Yihan, Du, Pingwu“…Riemann surfaces inspired chemists to design and synthesize such multidimensional curved carbon architectures. …”
Publicado 2023
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1417“…It is undoubtedly worth spreading the news that AI researchers can rely on the help of chemists and biotechnologists to reach the ambitious goals of building intelligent systems from scratch. …”
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1418“…Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and pharmaceutical agents. …”
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1419“…MATERIALS AND METHODS: Prevalence of type 1 diabetes was assessed by a hospital-based registry and by analysis of data contributed by chemists and other physicians. RESULTS: The overall prevalence of type 1 diabetes in Karnal district is 10.20/100,000 population, with a higher prevalence in urban (26.6/100,000) as compared to rural areas (4.27/100,000). …”
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1420por Friedman, Aaron J, Durrant, Jacob D, Pierce, Levi C T, McCorvie, Thomas J, Timson, David J, McCammon, J Andrew“…UDP-galactose 4′-epimerase (TbGalE) is responsible for the epimerization of UDP-glucose to UDP-galactose and is therefore of great interest to medicinal chemists. Using molecular dynamics simulations, we investigate the atomistic motions of TbGalE in both the apo and holo states. …”
Publicado 2012
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