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  1. 1681
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    Food effect risk assessment in preformulation stage using material sparing μFLUX methodology
  2. 1682
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    Numerical modeling of the dissolution of drug nanocrystals and its application to industrial product development
  3. 1683
    “…The nascent field of computationally aided molecular design will be built around the ability to make computation useful to synthetic chemists who draw on their empirically based chemical intuition to synthesize new and useful molecules. …”
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    Unicorns, Rhinoceroses and Chemical Bonds
  4. 1684
    “…In 1971, chemists from Hoffmann-La Roche and Schering AG independently discovered a new asymmetric intramolecular aldol reaction catalyzed by the natural amino acid proline, a transformation now known as the Hajos–Parrish–Eder–Sauer–Wiechert reaction. …”
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    Recent Advances in Asymmetric Synthesis of Pyrrolidine-Based Organocatalysts and Their Application: A 15-Year Update
  5. 1685
    “…Since 2001, when the concept of click chemistry was advanced by Sharpless laboratory, synthetic chemists started to envision click reactions as the preferred choice of synthetic methodology employed to create new functions. …”
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    Assembling Complex Macromolecules and Self-Organizations of Biological Relevance with Cu(I)-Catalyzed Azide-Alkyne, Thio-Bromo, and TERMINI Double “Click” Reactions †
  6. 1686
    “…Chirality is pivotal in nature which attracts wide research interests from all disciplines and creating chiral matter is one of the central themes for chemists and material scientists. Despite of significant efforts, a simple, cost-effective and general method that can produce different kinds of chiral metamaterials with high regularity and tailorability is still demanding but greatly missing. …”
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    Polarization-directed growth of spiral nanostructures by laser direct writing with vector beams
  7. 1687
    “…The method was validated according to the Association of Official Analytical Chemists guidelines and met the criteria. A single matrix-matched calibration method with bracken fern has been proposed, which is a novel strategy that uses one calibration for multiple matrices. …”
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    Evaluation and Monitoring of the Natural Toxin Ptaquiloside in Bracken Fern, Meat, and Dairy Products
  8. 1688
    por Yuan, Haoyin, Yin, Wenhao, Hu, Jili, Li, Yang
    Publicado 2023
    “…Benzyne has long captivated the attention of chemists and has gained numerous synthetic achievements. …”
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    3-sulfonyloxyaryl(mesityl)iodonium triflates as 1,2-benzdiyne precursors with activation via ortho-deprotonative elimination strategy
  9. 1689
    por El-Deiry, Wafik S.
    Publicado 2023
    “…The article focuses on a functional p53 pathway restoration approach to drug discovery that years ago was not mainstream, encouraged by anyone, taught in textbooks, or embraced by medicinal chemists. With some knowledge, a clinician scientist's interest, and motivation, the author pursued a unique line of investigation leading to insights for functional bypass of TP53 mutations in human cancer. …”
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    Targeting Mutated p53: Naivete and Enthusiasm to Attempt the Impossible
  10. 1690
    “…Recent developments and potential new directions summarized here will, hopefully, serve as valuable perspectives for investigators including medicinal chemists and drug discovery researchers to utilize chalcone as a scaffold for developing novel NLRP3 inflammasome inhibitors.…”
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    Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors
  11. 1691
    por Peluso, Paola, Mamane, Victor
    Publicado 2022
    “…On the other hand, enantioselective high‐performance liquid chromatography has been frequently used by organic and organometallic chemists in order to measure the enantiomeric purity of planar chiral ferrocenes prepared by asymmetric synthesis. …”
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    Ferrocene derivatives with planar chirality and their enantioseparation by liquid‐phase techniques
  12. 1692
    “…In the past two decades, drug candidates with a covalent binding mode have gained the interest of medicinal chemists, as several covalent anticancer drugs have successfully reached the clinic. …”
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    Technologies for Direct Detection of Covalent Protein–Drug Adducts
  13. 1693
    “…Understanding of design rules and roles of GluN2B selective compounds will provide the link to medicinal chemists and neuroscientists to explore novel neurotherapeutic strategies against dysfunctions of glutamatergic neurotransmission. …”
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    GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics
  14. 1694
    “…A long-lasting goal of computational biochemists, medicinal chemists, and structural biologists has been the development of tools capable of deciphering the molecule–molecule interaction code that produces a rich variety of complex biomolecular assemblies comprised of the many different simple and biological molecules of life: water, small metabolites, cofactors, substrates, proteins, DNAs, and RNAs. …”
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    HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham
  15. 1695
    “…Analyzing essential oils is a challenging task for chemists because their composition can vary depending on various factors. …”
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    Aroma Compounds in Essential Oils: Analyzing Chemical Composition Using Two-Dimensional Gas Chromatography–High Resolution Time-of-Flight Mass Spectrometry Combined with Chemometrics
  16. 1696
    “…We believe these findings may enlighten medicinal chemists on the structure design and optimization of ligands using the bioisosteric replacement strategy.…”
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    Identified Isosteric Replacements of Ligands’ Glycosyl Domain by Data Mining
  17. 1697
    “…Emerged 2D materials have attracted extensive scientific interest as fundamental building blocks or nanostructures among material scientists, chemists, biologists, and doctors due to their advantageous physicochemical and biological properties. …”
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    Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms
  18. 1698
    “…However, the development of inexpensive, reproducible, and reusable enhancing substrates remains a challenge for material scientists and analytical chemists. In this study, we address this challenge by demonstrating the deposition of core–shell nanoparticles consisting of a gold core and a thin inert SiO(2) shell within a confined space, resulting in the formation of a highly efficient Raman-enhancing structure. …”
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    Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection
  19. 1699
    “…Due to their structural diversity, these cyclic ketals have attracted the interest of chemists and biologists. SPK1, SPK2, and SPK3 were evaluated here for their ability to inhibit HIV-1 integrase activity in biochemical assays. …”
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    HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France)
  20. 1700
    por Bhujbal, Swapnil P., Hah, Jung-Mi
    Publicado 2023
    “…This summary endeavors to guide medicinal chemists in their quest to design covalent inhibitors for protein kinases, specifically targeting neurodegenerative diseases.…”
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    An Innovative Approach to Address Neurodegenerative Diseases through Kinase-Targeted Therapies: Potential for Designing Covalent Inhibitors
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