“…Nagasaki University collected many extracts from over 18,000 marine bacteria found in local Omura bay, and continues to compile an extensive collection of synthetic compounds from numerous drug libraries established by Japanese chemists.…”
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“…Information provided in this data file can be used in organic synthesis by other chemists to develop synthetic strategies for the construction of various cationic 1,4-dihydropyridine derivatives and related heterocycles.…”
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“…[Image: see text] Rational compound design remains a challenging problem for both computational methods and medicinal chemists. Computational generative methods have begun to show promising results for the design problem. …”
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“…Once established, this assay was used to validate novel TMEM16A inhibitors that were identified in our high-throughput fluorescent-based assay, as well as to assist in structure–activity relationship efforts by the chemists. Overall, we demonstrate an easy to operate, reproducible, automated electrophysiology assay using the QPatch-48 for TMEM16A drug development efforts.…”
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“…Further, the clear assignment of the origins of Mo VtC XES features opens up the possibility of applying this method to a wide range of second‐row transition metals, thus providing chemists with a site‐specific tool for the elucidation of 4d transition metal electronic structure.…”
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“…The H(p)(0.07) personal dose equivalent values obtained for the fingertips of the index and middle fingers of nursing staff and chemists were within the range limited by the minimum and maximum H(p)(0.07) values obtained as a result of dosimetric measurements carried out in diagnostic and production centers. …”
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“…The large number of possibilities and the versatility of these approaches, the main challenges to face in order to achieve other pursued capabilities (development of antifouling, continuous operation, wash-, calibration- and reagents-free devices, regulatory or Association of Official Analytical Chemists, AOAC, approval) and decisive future actions to achieve the commercialization and acceptance of these devices in our daily routine are also noted at the end.…”
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“…After harvesting at pre-flowering (61 days after planting), flowering (71 days after planting) and post-flowering (91 days after planting) stages, nutrient and antinutrient analyses were carried out following Association of Official Analytical Chemists (AOAC) and other referenced methods while the Inductively Coupled Plasma- Optical Emission Spectrometer was used to determine mineral compositions of the plant samples. …”
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“…[Image: see text] Berberine (BBR), a well-known alkaloid, exhibits various pharmacological activities, especially hypolipidemic activity, which has attracted much interest from medicinal chemists in the past decade. However, little progress was made on the structural modification of BBR for improving lipid-lowering activity, mainly due to its unclear biological target and low safety. …”
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“…The method should be of use to atmospheric chemists, tree physiologists and forest entomologists, among others.…”
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“…Therefore, seeds of crop plants are intensively studied by food chemists, biologists, biochemists, and nutritional physiologists. …”
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“…The concepts of “characteristic distortivity” and “transition state acidity” of a reaction are introduced, which have the potential to enable chemists to better understand and design reactions for synthesis.…”
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“…Increasing efforts by computational chemists have developed effective software to overcome the restrictions of torsional and conformational freedom that arise as a consequence of macrocyclization. …”
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“…One Biosecurity will require the bringing together of taxonomists, population biologists, modellers, economists, chemists, engineers, and social scientists to engage in a new agenda that is shaped by politics, legislation, and public perceptions.…”
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“…For the last two decades, the development of conducting polymers (CP) as artificial muscles, by materials researchers and chemists, has made establishing a reliable and repeatable synthesis of such materials possible. …”
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“…Simplified, artistic, or economic tables are relevant to educational and cultural fields, while practicing chemists profit more from “chemical tables of chemical elements.” …”
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“…There is a good correspondence between the Hückel method in chemistry and graph theory in mathematics; the molecular orbital, which chemists view as the distribution of an electron with a specific energy, is to mathematicians an algebraic entity, an eigenvector. …”
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“…The use of cisplatin is severely limited by its toxic side-effects, which has spurred chemists to employ different strategies in the development of new metal-based anticancer agents. …”
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“…Our team approach with schistosome biologists, medicinal chemists, structural biologists and geneticists has enabled us to develop and test novel drug derivatives of OXA to treat this disease. …”
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“…The selectivity of α4β2 nAChR agonists over the α3β4 nicotinic receptor subtype, predominant in ganglia, primarily conditions their therapeutic range and it is still a complex and challenging issue for medicinal chemists and pharmacologists. Here, we investigate the determinants for such subtype selectivity in a series of more than forty α4β2 ligands we have previously reported, docking them into the structures of the two human subtypes, recently determined by cryo-electron microscopy. …”
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