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88361por Hong, Hye-Ryun, Ha, Chang-Duk, Kong, Ji-Young, Lee, Sang-Hee, Song, Moon-Goo, Kang, Hyun-Sik“…Fasting blood samples were collected for blood chemistry assays including lipids, glucose, insulin and homeostasis model assessment for insulin resistance (HOMA-IR), leptin, and adiponectin. …”
Publicado 2014
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88362por Akhondi, Saber A, Hettne, Kristina M, van der Horst, Eelke, van Mulligen, Erik M, Kors, Jan A“…BACKGROUND: The past decade has seen an upsurge in the number of publications in chemistry. The ever-swelling volume of available documents makes it increasingly hard to extract relevant new information from such unstructured texts. …”
Publicado 2015
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88363“…[Image: see text] A rapid one-step (18)F labeling reaction with fluoridealuminum complex, which is based on chelation chemistry, has received a surge of interest for (18)F radiolabeling of peptides. …”
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88364por Eiring, Anna M., Page, Brent D. G., Kraft, Ira L., Mason, Clinton C., Vellore, Nadeem A., Resetca, Diana, Zabriskie, Matthew S., Zhang, Tian Y., Khorashad, Jamshid S., Engar, Alexander J., Reynolds, Kimberly R., Anderson, David J., Senina, Anna, Pomicter, Anthony D., Arpin, Carolynn C., Ahmad, Shazia, Heaton, William L., Tantravahi, Srinivas K., Todic, Aleksandra, Moriggl, Richard, Wilson, Derek J., Baron, Riccardo, O'Hare, Thomas, Gunning, Patrick T., Deininger, Michael W.“…By combining synthetic chemistry, in vitro reporter assays, and molecular dynamics-guided rational inhibitor design and high-throughput screening, we discovered BP-5-087, a potent and selective STAT3 SH2 domain inhibitor that reduces STAT3 phosphorylation and nuclear transactivation. …”
Publicado 2014
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88365por Dogan, Bercem Aycicek, Arduc, Ayse, Tuna, Mazhar Muslum, Karakılıc, Ersen, Dagdelen, Iffet, Tutuncu, Yasemin, Berker, Dilek, Guler, Serdar“…IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment. …”
Publicado 2014
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88366“…However, there were no differences in the efficacy between the two groups. The blood chemistry showed no toxicity on renal and/or liver functions after taking SHT for 28 days but the patients who took diclofenac showed significant increases in their AST, ALT, and ALP. …”
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88367“…Marine bacteria have so far not been exploited to the same extent; however, they are believed to harbor a multitude of novel bioactive chemistry. To explore this potential, genomes of 21 marine Alpha- and Gammaproteobacteria collected during the Galathea 3 expedition were sequenced and mined for natural product encoding gene clusters. …”
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88368por Pradeepkiran, Jangampalli Adi, Kumar, Konidala Kranthi, Kumar, Yellapu Nanda, Bhaskar, Matcha“…The modeled structure was optimized by applying a molecular dynamics simulation for 2 ns with the CHARMM (Chemistry at HARvard Macromolecular Mechanics) 27 force field in NAMD (NAnoscale Molecular Dynamics program; v 2.9) and then evaluated by calculating the stereochemical quality of the protein. …”
Publicado 2015
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88369por Hinkley, Georgia K, Carpinone, Paul, Munson, John W, Powers, Kevin W, Roberts, Stephen M“…Additional factors, such as surface chemistry, may have played a more important role than in vivo particle size and should be investigated further.…”
Publicado 2015
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88370“…The presence of tertiary amines in numerous alkaloids, pharmaceuticals, and agrochemicals lends credence to the potential utility of this chemistry in natural product synthesis, and herein we will discuss how these transformations might be controlled for synthetic purposes.…”
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88371por Figuera-Losada, Mariana, Stathis, Marigo, Dorskind, Joelle M., Thomas, Ajit G., Bandaru, Veera Venkata Ratnam, Yoo, Seung-Wan, Westwood, Nicholas J., Rogers, Graeme W., McArthur, Justin C., Haughey, Norman J., Slusher, Barbara S., Rojas, Camilo“…However, to date, there are no soluble, specific and potent small molecule inhibitor tool compounds for in vivo studies or as a starting point for medicinal chemistry optimization. Moreover, the majority of the known inhibitors were identified using bacterial, bovine or rat nSMase2. …”
Publicado 2015
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88372“…BACKGROUND: We recently synthesized a hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide-co-N-(3-azidopropyl)methacrylamide), p(HPMA-co-AzMA), by RAFT polymerization using a novel azide-containing methacrylamide monomer that through a post modification strategy using click chemistry enabled facile preparation of a panel of versatile and well-defined bioconjugates. …”
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88373
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88374por Lauster, Daniel, Pawolski, Damian, Storm, Julian, Ludwig, Kai, Volkmer, Rudolf, Memczak, Henry, Herrmann, Andreas, Bhatia, SumatiEnlace del recurso
Publicado 2015
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88375por Åstrand, Annika B M, Lamm Bergström, Eva, Zhang, Hui, Börjesson, Lena, Söderdahl, Therese, Wingren, Cecilia, Jansson, Anne-Helene, Smailagic, Amir, Johansson, Camilla, Bladh, Håkan, Shamovsky, Igor, Tunek, Anders, Drmota, Tomas“…To support the lead optimization chemistry program with compound selection and profiling, multiple in vitro and in vivo assays were used, characterizing compound properties, pharmacodynamics (PD), and drug concentrations. …”
Publicado 2015
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88376por Welby, Christine E, Armitage, Georgina K, Bartley, Harry, Wilkinson, Aaron, Sinopoli, Alessandro, Uppal, Baljinder S, Rice, Craig R, Elliott, Paul I PEnlace del recurso
Publicado 2014
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88377por Bhalla, Rajiv, Levason, William, Luthra, Sajinder K, McRobbie, Graeme, Sanderson, George, Reid, GillianEnlace del recurso
Publicado 2015
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88378por Pascanu, Vlad, Yao, Qingxia, Bermejo Gómez, Antonio, Gustafsson, Mikaela, Yun, Yifeng, Wan, Wei, Samain, Louise, Zou, Xiaodong, Martín-Matute, BelénEnlace del recurso
Publicado 2013
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88379por Biswas, Srijit, Dahlstrand, Christian, Watile, Rahul A, Kalek, Marcin, Himo, Fahmi, Samec, Joseph S MEnlace del recurso
Publicado 2013
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88380por Krasowski, Matthew D., Schriever, Andy, Mathur, Gagan, Blau, John L., Stauffer, Stephanie L., Ford, Bradley A.“…RESULT: We present examples of successful searches using Starmaker, falling mostly in the realm of microbiology and clinical chemistry/toxicology. The searches were ones that were either very difficult or basically infeasible using reporting tools within the EHR and LIS used in the medical center. …”
Publicado 2015
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