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  1. 89321
    “…The α351-380M mutant catalyzing oxidation of the phenolic substrate DMP effectively would be very useful in green chemistry.…”
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    Engineering Klebsiella sp. 601 multicopper oxidase enhances the catalytic efficiency towards phenolic substrates
  2. 89322
    “…METHODOLOGY/PRINCIPAL FINDINGS: A drug discovery project employing integrated biological screening, medicinal chemistry and pharmacokinetic characterization identified SCYX-7158 as an optimized analog, as it is active in vitro against relevant strains of Trypanosoma brucei, including T. b. rhodesiense and T. b. gambiense, is efficacious in both stage 1 and stage 2 murine HAT models and has physicochemical and in vitro absorption, distribution, metabolism, elimination and toxicology (ADMET) properties consistent with the compound being orally available, metabolically stable and CNS permeable. …”
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    SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis
  3. 89323
    “…Additionally, the IRIS platform is simple to use, requires inexpensive equipment, and utilizes silicon-based solid phase assay components making it compatible with many contemporary surface chemistry approaches. Here, we present the use of the IRIS system from preparation of probe arrays to incubation and measurement of target binding to analysis of the results in an endpoint format. …”
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    Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)
  4. 89324
    “…In addition, we also carried out the biomass composition analysis of nine Arabidopsis mutants with both MBMS analysis and traditional wet chemistry methods. The results were analyzed together with the genomics analysis. …”
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    Comparative genome analysis of lignin biosynthesis gene families across the plant kingdom
  5. 89325
    “…This protocol for bisulphite conversion is the "gold standard" for DNA methylation analysis and facilitates identification and quantification of DNA methylation at single nucleotide resolution. The chemistry of cytosine deamination by sodium bisulphite involves three steps (Figure 2). (1) Sulphonation: The addition of bisulphite to the 5-6 double bond of cytosine (2) Hydrolic Deamination: hydrolytic deamination of the resulting cytosine-bisulphite derivative to give a uracil-bisulphite derivative (3) Alkali Desulphonation: Removal of the sulphonate group by an alkali treatment, to give uracil. …”
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    DNA Methylation: Bisulphite Modification and Analysis
  6. 89326
    “…One focus of our research is furthering the chemistry of native chemical ligation (NCL) and expressed protein ligation (EPL), two related processes that enable the synthesis and semisynthesis of proteins. …”
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    Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium
  7. 89327
    “…RESULTS: A PAMAM dendrimer fully substituted by click chemistry on its peripheral groups with 64 moieties of a nucleoside agonist was shown to be potent and selective in binding to the mouse A(3)AR and effective in cardioprotection in an isolated mouse heart model of ischemia/reperfusion (I/R) injury. …”
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    Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A(3 )adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts
  8. 89328
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    A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space
  9. 89329
    “…The sex pheromone of D. tabulaeformis was investigated to define its chemistry and behavioral activity. METHODOLOGY/PRINCIPAL FINDINGS: Sex pheromone was collected from calling female D. tabulaeformis by headspace solid phase microextraction (SPME) and by solvent extraction of pheromone glands. …”
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    Identification and Behavioral Evaluation of Sex Pheromone Components of the Chinese Pine Caterpillar Moth, Dendrolimus tabulaeformis
  10. 89330
    “…Finally, we checked the effect of the ligation-based modification on the Infinium chemistry for SNP genotyping on an independent set of samples, which also showed poor performance. …”
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    Interpretation of genome-wide infinium methylation data from ligated DNA in formalin-fixed, paraffin-embedded paired tumor and normal tissue
  11. 89331
    “…Results: We have trained and compared machine learning classifiers (support vector machines and conditional random fields) on a corpus of 265 full articles in biochemistry and chemistry to automatically recognize CoreSCs. We have evaluated our automatic classifications against a manually annotated gold standard, and have achieved promising accuracies with ‘Experiment’, ‘Background’ and ‘Model’ being the categories with the highest F1-scores (76%, 62% and 53%, respectively). …”
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    Automatic recognition of conceptualization zones in scientific articles and two life science applications
  12. 89332
    “…BACKGROUND: Automated reporting of estimated glomerular filtration rate (eGFR) is a recent advance in laboratory information technology (IT) that generates a measure of kidney function with chemistry laboratory results to aid early detection of chronic kidney disease (CKD). …”
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    Implementation of automated reporting of estimated glomerular filtration rate among Veterans Affairs laboratories: a retrospective study
  13. 89333
    “…All the abnormal haematology and blood chemistry values had no clinical abnormality. CONCLUSION: AN and DHP are confirmed very effective, safe and tolerate for treatment of any malaria. …”
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    Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia
  14. 89334
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    Ageing of enteric neurons: oxidative stress, neurotrophic factors and antioxidant enzymes
  15. 89335
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    Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups
  16. 89336
    “…Patient specific costs were obtained prospectively from patient records and included personnel resources, medication, blood products, blood chemistry and microbiology, imaging and procedure costs including operating room costs. …”
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    Hospital costs fell as numbers of LVADs were increasing: experiences from Oslo University Hospital
  17. 89337
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    Determination of stanozolol and 3(′)-hydroxystanozolol in rat hair, urine and serum using liquid chromatography tandem mass spectrometry
  18. 89338
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    In-silico predictive mutagenicity model generation using supervised learning approaches
  19. 89339
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    Nutritive quality of romanian hemp varieties (Cannabis sativa L.) with special focus on oil and metal contents of seeds
  20. 89340
    “…BACKGROUND: Modern analytical methods in biology and chemistry use separation techniques coupled to sensitive detectors, such as gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). …”
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    Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets
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