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89581por Garbo, Corina, Locs, Janis, D’Este, Matteo, Demazeau, Gerard, Mocanu, Aurora, Roman, Cecilia, Horovitz, Ossi, Tomoaia-Cotisel, Maria“…METHODS: The ms-HAPs were obtained via a wet-chemistry precipitation route without the use of surfactants, which is a safe and ecologically friendly method. …”
Publicado 2020
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89582Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibitionpor Brito, Hugo, Marques, Vanda, Afonso, Marta B., Brown, Dean G., Börjesson, Ulf, Selmi, Nidhal, Smith, David M., Roberts, Ieuan O., Fitzek, Martina, Aniceto, Natália, Guedes, Rita C., Moreira, Rui, Rodrigues, Cecília M. P.“…In conclusion, a phenotypic-driven HTS cascade promptly identified robust necroptosis inhibitors with in vivo activity, currently undergoing further medicinal chemistry optimization. Notably, the novel hits highlight the opportunity to identify new molecular mechanisms of action in necroptosis.…”
Publicado 2020
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89583“…Clinical observations, physical examinations, complete blood counts, clinical chemistry, and plasma cannabinoids were used to assess safety, tolerability, and the occurrence of adverse events (AEs). …”
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89584por Kollmus, Heike, Fuchs, Helmut, Lengger, Christoph, Haselimashhadi, Hamed, Bogue, Molly A., Östereicher, Manuela A., Horsch, Marion, Adler, Thure, Aguilar-Pimentel, Juan Antonio, Amarie, Oana Veronica, Becker, Lore, Beckers, Johannes, Calzada-Wack, Julia, Garrett, Lillian, Hans, Wolfgang, Hölter, Sabine M., Klein-Rodewald, Tanja, Maier, Holger, Mayer-Kuckuk, Philipp, Miller, Gregor, Moreth, Kristin, Neff, Frauke, Rathkolb, Birgit, Rácz, Ildikó, Rozman, Jan, Spielmann, Nadine, Treise, Irina, Busch, Dirk, Graw, Jochen, Klopstock, Thomas, Wolf, Eckhard, Wurst, Wolfgang, Yildirim, Ali Önder, Mason, Jeremy, Torres, Arturo, Balling, Rudi, Mehaan, Terry, Gailus-Durner, Valerie, Schughart, Klaus, Hrabě de Angelis, Martin“…In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. …”
Publicado 2020
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89585por Haijes, H. A., Jans, J. J. M., van der Ham, M., van Hasselt, P. M., Verhoeven-Duif, N. M.“…METHODS: Longitudinal data from clinical chemistry analyses and metabolic assays over the life-course of 11 PA and 13 MMA patients were studied retrospectively. …”
Publicado 2020
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89586por Blake, Bevin E., Cope, Harlie A., Hall, Samantha M., Keys, Robert D., Mahler, Beth W., McCord, James, Scott, Brittany, Stapleton, Heather M., Strynar, Mark J., Elmore, Susan A., Fenton, Suzanne E.“…Gestational weight gain (GWG), maternal clinical chemistry, maternal liver histopathology, placental histopathology, embryo weight, placental weight, internal chemical dosimetry, and placental thyroid hormone levels were determined. …”
Publicado 2020
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89587“…Apart from being sustainable, biodegradable, and renewable, wood is also extremely fascinating from the application aspect, with numerous advantages including hierarchical and macroporous structure, excellent mechanical performance, and versatile chemistry. The macroporous structure of wood is comprised of numerous long, partially aligned channels along the growth direction. …”
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89588“…Strikingly, transcripts with higher abundance in the phenol-extracted samples were enriched for membrane proteins, suggesting that indeed the chemistry of hot phenol extraction better solubilizes those species of mRNA. …”
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89589por Teranishi, Shuhei, Kobayashi, Nobuaki, Katakura, Seigo, Kamimaki, Chisato, Kubo, Sousuke, Shibata, Yuji, Yamamoto, Masaki, Kudo, Makoto, Piao, Hongmei, Kaneko, Takeshi“…The relationship between IFN‐γ receptor and ODN was analyzed by ELISA and immunofluorescence chemistry. RESULTS: Our results verified that A‐CpG ODNs suppress the upregulation of IFN‐γ‐induced PD‐L1 and β2‐MG expression. …”
Publicado 2020
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89590por Rehder, Dieter“…Bones act as storage pool for vanadate. The aqueous chemistry of vanadium(V) at concentration <10 μM is dominated by vanadate. …”
Publicado 2013
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89591por van der Kooy, Frank“…One approach is in silico drug design based on our existing knowledge of the biology of a specific disease and the specific target site binding chemistry. Based on this knowledge, a range of molecules will be designed and synthesised after which they will be tested in in vitro bioassays for activity and toxicity. …”
Publicado 2013
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89592por Millischer, R.-J., de Rooij, C.G., Rush, G.M., Farr, C.H., Ben-Dyke, R., Hardy, C.J., Lewis, D.J., Hodson-Walker, G.“…No exposure-related effects of toxicological significance were noted with respect to survival, clinical signs, ophthalmoscopy, haematology, clinical chemistry, urinalysis or organ weight analysis. Reduced food intake and body weight gain were noted in both sexes of the 15,000 ppm group during the first 16 wk; thereafter, body weight gains in all groups were similar although the intergroup differences in body weight remained evident. …”
Publicado 1995
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89593por Liu, Yanna, Scrivano, Luca, Peterson, Julia Denise, Fens, Marcel H. A. M., Hernández, Irati Beltrán, Mesquita, Bárbara, Toraño, Javier Sastre, Hennink, Wim E., van Nostrum, Cornelus F., Oliveira, Sabrina“…To favor the uptake of the micelles by cancer cells that overexpress the epidermal growth factor receptor (EGFR), the micelles were decorated with an EGFR-targeted nanobody (named EGa1) through maleimide-thiol chemistry. The enhanced binding of the EGFR-targeted micelles at 4 °C to EGFR-overexpressing A431 cells, compared to low-EGFR-expressing HeLa cells, confirmed the specificity of the micelles. …”
Publicado 2020
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89594por Tetteh-Quarcoo, Patience B., Forson, Peter O., Amponsah, Seth K., Ahenkorah, John, Opintan, Japheth A., Ocloo, Janet E. Y., Okine, Esther N., Aryee, Robert, Afutu, Emmanuel, Anang, Abraham K., Ayeh-Kumi, Patrick F.“…The morbidity parameters were examined with urine chemistry strips, as well as microscopy. Viability was assessed using a modified hatchability technique, vital staining (0.4% trypan blue and 1% neutral red) and fluorescent (Hoechst 33258) microscopy. …”
Publicado 2020
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89595The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation“…This review covers the organic chemistry, enzymology, and molecular biology of 2–5A and its associated enzymes. …”
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89596por Kang, Kai, Ma, Yeshuo, Jia, Chongfu, Cheng, Yunpeng, Yang, Yingchao, Wang, Lixin, Jiang, Yinong, Lu, Yan“…METHODS: One hundred and sixty-two middle-aged (mean 39.82 ± 10.25 years, 58.0% male) patients with primary hypertension were enrolled, and patients underwent Computed Tomography Angiography (CTA) of renal arteries, ambulatory blood pressure monitor (ABPM), echocardiography, physical examination, and routine blood chemistry examinations. According to the CTA results, patients were divided into a non-ARA (n = 108) and ARA (n = 54) group. …”
Publicado 2020
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89597“…We studied the CTC identified in 45 CTC-positive men by Immuno-Cyto-Chemistry (ICC) assays with the prostate-specific-marker PSA. …”
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89598por Sarih, Norfatirah Muhamad, Ciupa, Alexander, Moss, Stephen, Myers, Peter, Slater, Anna Grace, Abdullah, Zanariah, Tajuddin, Hairul Anuar, Maher, Simon“…Furocoumarin (furo[3,2-c]coumarin) derivatives have been synthesized from single step, high yielding (82–92%) chemistry involving a 4-hydroxycoumarin 4 + 1 cycloaddition reaction. …”
Publicado 2020
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89599por Liu, F., Cottrell, J. J., Wijesiriwardana, U., Kelly, F. W., Chauhan, S. S., Pustovit, R. V., Gonzales-Rivas, P. A., DiGiacomo, K., Leury, B. J., Celi, P., Dunshea, F. R.“…The physiological responses to HS were monitored by measuring respiration rate, rectal temperature, blood gas chemistry, and feed intake during thermal exposure. …”
Publicado 2017
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89600por Basciani, Sabrina, Camajani, Elisabetta, Contini, Savina, Persichetti, Agnese, Mariani, Stefania, Lubrano, Carla, Watanabe, Mikiko, Faro, Maria, Bernardo, Settimia Di, Vari, Michaela, Risi, Renata, Strigari, Lidia, Gnessi, Lucio“…Materials and Methods. 48 obese patients (19 males and 29 females) with HOMA-index ≥ 2.5, age mean: 55.2 years (range: 45-73), BMI mean 35.9 kg/m2 (range: 30.2 - 46.4) were randomly assigned to three isocaloric VLCKD regimens (≤800 kcal/day) containing either whey, plant or animal proteins for 45 days, with assessments of anthropometric indexes, blood and urine chemistry, body composition, muscle strength, taxonomic composition of the gut microbiome. …”
Publicado 2020
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