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  1. 90561
    “…The Myelodysplastic Syndrome-Specific Comorbidity Index (MDS-CI) offers a simple tool for CM assessment as it is calculable after having performed a careful history and physical examination, a small routine chemistry panel (including creatinine and liver enzymes) and a limited set of functional diagnostics. …”
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    Prognostic Significance of the Myelodysplastic Syndrome-Specific Comorbidity Index (MDS-CI) in Patients with Myelofibrosis: A Retrospective Study
  2. 90562
    “…OBJECTIVE: The aim of this paper is to further analyse the role of quality/chemistry, manufacturing and controls (CMC) and clinical data for the conclusion on biosimilarity and the decision on marketing authorisation (MA). …”
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    Do the Outcomes of Clinical Efficacy Trials Matter in Regulatory Decision-Making for Biosimilars?
  3. 90563
    “…A comparison of tumor and germline whole exome sequencing was used to identify patient-specific tumor variant signatures and generate patient-specific panels, followed by targeted next-generation sequencing of plasma-derived cfDNA using the patient-specific panels with anchored multiplex polymerase chain reaction chemistry leveraging unique molecular identifiers. …”
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    Personalized Cancer Monitoring Assay for the Detection of ctDNA in Patients with Solid Tumors
  4. 90564
    “…C-reactive protein (CRP) was measured using a clinical chemistry analyser. Plasma concentrations of D-dimer and von Willebrand factor (vWF) were measured using enzyme-linked fluorescent assays (ELFA). …”
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    Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers
  5. 90565
    “…Chelex-treated buffers were used to prevent Fenton chemistry-mediated generation of reactive oxygen species (ROS) and artifactual oxidation of DNA bases. …”
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    Analysis of 7,8-Dihydro-8-oxo-2′-deoxyguanosine in Cellular DNA during Oxidative Stress
  6. 90566
    por Wells, Timothy NC
    Publicado 2011
    “…After improvement with medicinal chemistry and formulation technologies, and combination with other active ingredients, they now make up the current armamentarium of medicines. …”
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    Natural products as starting points for future anti-malarial therapies: going back to our roots?
  7. 90567
    por Ricker, Richard E.
    Publicado 2010
    “…The emphasis was on identifying trends in the data that could be later exploited in the development of an empirical model for predicting the range of expected corrosion behavior for any given set of soil chemistry and conditions. A large number of issues were identified with this corrosion dataset, but given the limited knowledge of corrosion and statistical analysis at the time the study was conducted, these shortcomings are not surprising and many of these were recognized by the investigators before the study was concluded. …”
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    Analysis of Pipeline Steel Corrosion Data From NBS (NIST) Studies Conducted Between 1922–1940 and Relevance to Pipeline Management
  8. 90568
    “…RESULTS: There were no test article-related adverse effects on body weight and/or food consumption, ophthalmology, electrocardiography, hematology, coagulation parameters, clinical chemistry, urinalysis, or organ weights, and no macroscopic findings at necropsy in any study. …”
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    A novel nasal powder formulation of glucagon: toxicology studies in animal models
  9. 90569
    “…Being the first assessment of its kind on the potential application of Ethiopian traditional medicinal plants for interference in microbial cell-cell communication (anti-Quorum Sensing activities), the detailed chemistry of the active compounds and possible mechanism(s) of actions of the bio-molecules responsible for the observed interference were not addressed in the current study. …”
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    Antimicrobial and anti-Quorum Sensing activities of selected medicinal plants of Ethiopia: Implication for development of potent antimicrobial agents
  10. 90570
    “…In addition to a number of anthropometric (height, weight, body mass index, waist circumference, body composition), clinical (blood pressure, electrocardiogram, blood and urine clinical chemistry) and functional parameters (lung function, arterial stiffness), resting metabolic rate, physical activity, fitness, and dietary intake were assessed, and 24-hour urine, fasting spot urine, and plasma samples were collected. …”
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    The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women
  11. 90571
    “…The aim of our study was to validate PacBio P6 sequencing chemistry using three approaches: 1) sequencing the full-length bacterial 16S rRNA gene from a single bacterial species Staphylococcus aureus to analyze error modes and to optimize the bioinformatics pipeline; 2) sequencing the full-length bacterial 16S rRNA gene from a pool of 50 different bacterial colonies from human stool samples to compare with full-length bacterial 16S rRNA capillary sequence; and 3) sequencing the full-length bacterial 16S rRNA genes from 11 vaginal microbiome samples and compare with in silico selected bacterial 16S rRNA V1V2 gene region and with bacterial 16S rRNA V1V2 gene regions sequenced using the Illumina MiSeq. …”
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    Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification
  12. 90572
    “…In the framework of the third phase of the Air Quality Model Evaluation International Initiative (AQMEII3), and as contribution to the second phase of the Hemispheric Transport of Air Pollution (HTAP2) activities for Europe and North America, the impacts of a 20 % decrease of global and regional anthropogenic emissions on surface air pollutant levels in 2010 are simulated by an international community of regional-scale air quality modeling groups, using different state-of-the-art chemistry and transport models (CTMs). The emission perturbations at the global level, as well as over the HTAP2-defined regions of Europe, North America and East Asia, are first simulated by the global Composition Integrated Forecasting System (C-IFS) model from European Centre for Medium-Range Weather Forecasts (ECMWF), which provides boundary conditions to the various regional CTMs participating in AQMEII3. …”
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    Influence of anthropogenic emissions and boundary conditions on multi-model simulations of major air pollutants over Europe and North America in the framework of AQMEII3
  13. 90573
    “…DNA was extracted from cultured isolates using the Zymo Research Quick-DNA™ Fungal/Bacterial Miniprep kit, sequencing libraries prepared (Nextera® XT PE), and sequencing (Illumina MiSeq® with V2 2 X 250 bp chemistry) completed for the 2 blood and 1 BM isolates. …”
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    1517. Multidrug-Resistant Escherichia coli ST131 Late-Onset Neonatal Sepsis in Premature Twins Linked to Contaminated Maternal Frozen Breast Milk
  14. 90574
    por van Santen, Jeffrey A., Jacob, Grégoire, Singh, Amrit Leen, Aniebok, Victor, Balunas, Marcy J., Bunsko, Derek, Neto, Fausto Carnevale, Castaño-Espriu, Laia, Chang, Chen, Clark, Trevor N., Cleary Little, Jessica L., Delgadillo, David A., Dorrestein, Pieter C., Duncan, Katherine R., Egan, Joseph M., Galey, Melissa M., Haeckl, F.P. Jake, Hua, Alex, Hughes, Alison H., Iskakova, Dasha, Khadilkar, Aswad, Lee, Jung-Ho, Lee, Sanghoon, LeGrow, Nicole, Liu, Dennis Y., Macho, Jocelyn M., McCaughey, Catherine S., Medema, Marnix H., Neupane, Ram P., O’Donnell, Timothy J., Paula, Jasmine S., Sanchez, Laura M., Shaikh, Anam F., Soldatou, Sylvia, Terlouw, Barbara R., Tran, Tuan Anh, Valentine, Mercia, van der Hooft, Justin J. J., Vo, Duy A., Wang, Mingxun, Wilson, Darryl, Zink, Katherine E., Linington, Roger G.
    Publicado 2019
    “…[Image: see text] Despite rapid evolution in the area of microbial natural products chemistry, there is currently no open access database containing all microbially produced natural product structures. …”
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    The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery
  15. 90575
    “…METHODS: Twelve‐month‐old Ctns(−/−) mice and wild‐type controls were treated with 25(OH)D(3) and 1,25(OH)(2)D(3) (75 μg/kg/day and 60 ng/kg/day, respectively) or an ethylene glycol vehicle for 6 weeks. Serum chemistry and parameters of energy homeostasis were measured. …”
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    Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis‐associated cachexia
  16. 90576
    “…Acute toxicity was assessed in Sprague-Dawley rats at the dose of 0.742 mg/kg [(19)F]AmBF(3)-TATE, with a 14-day observation/recovery period. Blood chemistry parameters, gross, and histopathology were evaluated. …”
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    Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [(18)F]AmBF(3)-TATE
  17. 90577
    por Prasad, Ananda S.
    Publicado 2017
    “…Zinc acetate lozenges have been shown to decrease the duration of the common cold by 50%, provided the treatment is started within 24 h of the onset of symptoms, the solution chemistry of the zinc preparation is proper, and the zinc dosages are adequate. …”
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    Discovery of Zinc for Human Health and Biomarkers of Zinc Deficiency
  18. 90578
    “…Chest radiograph showed hazy opacities in the right upper to middle region. Blood chemistry revealed severe hyponatremia (114 mmol/L, NV 135-145 mmol/L) and low serum osmolality (247 mOsm/kg, NV 280-300 mOsm/kg). …”
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    SUN-276 Pembrolizumab-Induced Secondary Adrenal Insufficiency Presenting as Severe Hyponatremia in an 80-Year-Old Male
  19. 90579
    “…Each assay reflects different oxidising properties of PM(2.5), including particle-bound reactive oxygen species (DCFH), superoxide radical production (EPR) and catalytic redox chemistry (DTT/AA), and a combination of these four assays provided a detailed overall picture of the oxidising properties of PM(2.5) at a central site in Beijing. …”
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    Atmospheric conditions and composition that influence PM(2.5) oxidative potential in Beijing, China
  20. 90580
    “…RESULTS: The decay corrected yield of (68)Ga at EOB was typically > 3.7 GBq (100 mCi) for a 60 min beam, with irradiations of [(68)Zn]Zn(NO(3))(2) at 0.3 M HNO(3.) Target/chemistry performance was more consistent when compared with 0.2 M HNO(3). …”
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    Cyclotron-based production of (68)Ga, [(68)Ga]GaCl(3), and [(68)Ga]Ga-PSMA-11 from a liquid target
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